An NTS-CeA projection modulates depression-like behaviors in a mouse model of chronic pain
Depressive symptoms comorbid with chronic pain are a common health problem, but the underlying neural circuit mechanisms remain elusive. Here, we identify a glutamatergic projection from the nucleus of the solitary tract (NTS) to the central nucleus of the amygdala (CeA) that mediates depression-lik...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996122002856 |
| _version_ | 1828310263024058368 |
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| author | Shilang He Xuelin Huang Jun Zheng Yuehong Zhang Xiangcai Ruan |
| author_facet | Shilang He Xuelin Huang Jun Zheng Yuehong Zhang Xiangcai Ruan |
| author_sort | Shilang He |
| collection | DOAJ |
| description | Depressive symptoms comorbid with chronic pain are a common health problem, but the underlying neural circuit mechanisms remain elusive. Here, we identify a glutamatergic projection from the nucleus of the solitary tract (NTS) to the central nucleus of the amygdala (CeA) that mediates depression-like behaviors in a chemotherapy-induced neuropathic pain model. Inhibition or ablation of the glutamatergic NTS neurons alleviates depressive but not hypersensitive behaviors in these mice. The projected neurons form excitatory synapses with somatostatin-expressing neurons in the CeA. Silencing the NTS-CeA projection alleviates depressive but not hypersensitive behaviors, whereas activating the proection promotes depressive behaviors. In addition, in naïve mice, activation of the NTS-CeA projection induces obvious depressive behaviors that can be blocked by silencing the CeA somatostatin-expressing neurons. Together, we reveal a modulatory role of the NTS and its glutamatergic projection to the CeA circuit in modulating depression-like behaviors comorbid to chronic pain. |
| first_indexed | 2024-04-13T15:42:03Z |
| format | Article |
| id | doaj.art-4fe73c32c3dd4cfdb2c863dce4be9fa6 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-04-13T15:42:03Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-4fe73c32c3dd4cfdb2c863dce4be9fa62022-12-22T02:41:08ZengElsevierNeurobiology of Disease1095-953X2022-11-01174105893An NTS-CeA projection modulates depression-like behaviors in a mouse model of chronic painShilang He0Xuelin Huang1Jun Zheng2Yuehong Zhang3Xiangcai Ruan4Department of Anesthesia and Pain Medicine, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510655, ChinaDepartment of Anesthesiology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510000, ChinaDepartment of Anesthesiology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510000, ChinaDepartment of Ophthalmology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510000, ChinaDepartment of Anesthesia and Pain Medicine, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510655, China; Corresponding author.Depressive symptoms comorbid with chronic pain are a common health problem, but the underlying neural circuit mechanisms remain elusive. Here, we identify a glutamatergic projection from the nucleus of the solitary tract (NTS) to the central nucleus of the amygdala (CeA) that mediates depression-like behaviors in a chemotherapy-induced neuropathic pain model. Inhibition or ablation of the glutamatergic NTS neurons alleviates depressive but not hypersensitive behaviors in these mice. The projected neurons form excitatory synapses with somatostatin-expressing neurons in the CeA. Silencing the NTS-CeA projection alleviates depressive but not hypersensitive behaviors, whereas activating the proection promotes depressive behaviors. In addition, in naïve mice, activation of the NTS-CeA projection induces obvious depressive behaviors that can be blocked by silencing the CeA somatostatin-expressing neurons. Together, we reveal a modulatory role of the NTS and its glutamatergic projection to the CeA circuit in modulating depression-like behaviors comorbid to chronic pain.http://www.sciencedirect.com/science/article/pii/S0969996122002856DepressionChronic painSolitary tractAmygdalaNeural pathwaysOptogenetics |
| spellingShingle | Shilang He Xuelin Huang Jun Zheng Yuehong Zhang Xiangcai Ruan An NTS-CeA projection modulates depression-like behaviors in a mouse model of chronic pain Neurobiology of Disease Depression Chronic pain Solitary tract Amygdala Neural pathways Optogenetics |
| title | An NTS-CeA projection modulates depression-like behaviors in a mouse model of chronic pain |
| title_full | An NTS-CeA projection modulates depression-like behaviors in a mouse model of chronic pain |
| title_fullStr | An NTS-CeA projection modulates depression-like behaviors in a mouse model of chronic pain |
| title_full_unstemmed | An NTS-CeA projection modulates depression-like behaviors in a mouse model of chronic pain |
| title_short | An NTS-CeA projection modulates depression-like behaviors in a mouse model of chronic pain |
| title_sort | nts cea projection modulates depression like behaviors in a mouse model of chronic pain |
| topic | Depression Chronic pain Solitary tract Amygdala Neural pathways Optogenetics |
| url | http://www.sciencedirect.com/science/article/pii/S0969996122002856 |
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