An Update in Cystic Fibrosis-Related Diabetes in Children and Adolescents
This paper delineates several aspects of cystic fibrosis-related diabetes (CFRD)—a common complication of cystic fibrosis (CF). CFRD exhibits a predilection for older individuals with CF, yet it also extends its influence on children and adolescents. Scientific insights postulate a potential link be...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/10/12/1879 |
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| author | Dana-Teodora Anton-Păduraru Alina Mariela Murgu Mădălina Andreea Donos Felicia Trofin Alice Nicoleta Azoicăi Paula Popovici Aurelian Bogdan Stana Ionela Gheorghiescu Laura Mihaela Trandafir |
| author_facet | Dana-Teodora Anton-Păduraru Alina Mariela Murgu Mădălina Andreea Donos Felicia Trofin Alice Nicoleta Azoicăi Paula Popovici Aurelian Bogdan Stana Ionela Gheorghiescu Laura Mihaela Trandafir |
| author_sort | Dana-Teodora Anton-Păduraru |
| collection | DOAJ |
| description | This paper delineates several aspects of cystic fibrosis-related diabetes (CFRD)—a common complication of cystic fibrosis (CF). CFRD exhibits a predilection for older individuals with CF, yet it also extends its influence on children and adolescents. Scientific insights postulate a potential link between CFRD and the aberrant mucus production within the pancreas, thereby culminating in pancreatic insufficiency. This, in turn, perturbs the synthesis of insulin, a pivotal endocrine hormone responsible for the regulation of glycemic levels. Standardized protocols advocate for the systematic screening of CFRD among all individuals with CF, commencing at the age of 10 years using the oral glucose tolerance test (OGTT). Therapeutic modalities encompass insulin therapy, dietary adjustments, and the vigilant monitoring of glycemic parameters. The overarching objective is to maintain blood glucose levels within a targeted range to mitigate the advent of diabetic complications. Untreated or sub-optimally managed CFRD can precipitate a spectrum of deleterious health ramifications, encompassing cardiovascular afflictions, neuropathy, renal dysfunction, and ocular complications. |
| first_indexed | 2024-03-08T20:53:35Z |
| format | Article |
| id | doaj.art-4fe78d7a905b4a0e935af7f1837fd5cf |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-08T20:53:35Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-4fe78d7a905b4a0e935af7f1837fd5cf2023-12-22T14:00:22ZengMDPI AGChildren2227-90672023-11-011012187910.3390/children10121879An Update in Cystic Fibrosis-Related Diabetes in Children and AdolescentsDana-Teodora Anton-Păduraru0Alina Mariela Murgu1Mădălina Andreea Donos2Felicia Trofin3Alice Nicoleta Azoicăi4Paula Popovici5Aurelian Bogdan Stana6Ionela Gheorghiescu7Laura Mihaela Trandafir8Department of Mother and Child Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Mother and Child Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Mother and Child Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Preventive Medicine and Interdisciplinarity—Microbiology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Mother and Child Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Mother and Child Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Mother and Child Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaFaculty of General Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Mother and Child Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaThis paper delineates several aspects of cystic fibrosis-related diabetes (CFRD)—a common complication of cystic fibrosis (CF). CFRD exhibits a predilection for older individuals with CF, yet it also extends its influence on children and adolescents. Scientific insights postulate a potential link between CFRD and the aberrant mucus production within the pancreas, thereby culminating in pancreatic insufficiency. This, in turn, perturbs the synthesis of insulin, a pivotal endocrine hormone responsible for the regulation of glycemic levels. Standardized protocols advocate for the systematic screening of CFRD among all individuals with CF, commencing at the age of 10 years using the oral glucose tolerance test (OGTT). Therapeutic modalities encompass insulin therapy, dietary adjustments, and the vigilant monitoring of glycemic parameters. The overarching objective is to maintain blood glucose levels within a targeted range to mitigate the advent of diabetic complications. Untreated or sub-optimally managed CFRD can precipitate a spectrum of deleterious health ramifications, encompassing cardiovascular afflictions, neuropathy, renal dysfunction, and ocular complications.https://www.mdpi.com/2227-9067/10/12/1879cystic fibrosiscomplicationscystic fibrosis-related diabeteschildrenadolescents |
| spellingShingle | Dana-Teodora Anton-Păduraru Alina Mariela Murgu Mădălina Andreea Donos Felicia Trofin Alice Nicoleta Azoicăi Paula Popovici Aurelian Bogdan Stana Ionela Gheorghiescu Laura Mihaela Trandafir An Update in Cystic Fibrosis-Related Diabetes in Children and Adolescents Children cystic fibrosis complications cystic fibrosis-related diabetes children adolescents |
| title | An Update in Cystic Fibrosis-Related Diabetes in Children and Adolescents |
| title_full | An Update in Cystic Fibrosis-Related Diabetes in Children and Adolescents |
| title_fullStr | An Update in Cystic Fibrosis-Related Diabetes in Children and Adolescents |
| title_full_unstemmed | An Update in Cystic Fibrosis-Related Diabetes in Children and Adolescents |
| title_short | An Update in Cystic Fibrosis-Related Diabetes in Children and Adolescents |
| title_sort | update in cystic fibrosis related diabetes in children and adolescents |
| topic | cystic fibrosis complications cystic fibrosis-related diabetes children adolescents |
| url | https://www.mdpi.com/2227-9067/10/12/1879 |
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