A case report of Talaromyces marneffei Oro-pharyngo-laryngitis: a rare manifestation of Talaromycosis
Abstract Background The incidence of Taralomyces marneffei infection in HIV-infected individuals has been decreasing, whereas its rate is rising among non-HIV immunodeficient persons, particularly patients with anti-interferon-gamma autoantibodies. T. marneffei usually causes invasive and disseminat...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-12-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-019-4650-7 |
| _version_ | 1818432747744526336 |
|---|---|
| author | Thanyarak Wongkamhla Piriyaporn Chongtrakool Anupop Jitmuang |
| author_facet | Thanyarak Wongkamhla Piriyaporn Chongtrakool Anupop Jitmuang |
| author_sort | Thanyarak Wongkamhla |
| collection | DOAJ |
| description | Abstract Background The incidence of Taralomyces marneffei infection in HIV-infected individuals has been decreasing, whereas its rate is rising among non-HIV immunodeficient persons, particularly patients with anti-interferon-gamma autoantibodies. T. marneffei usually causes invasive and disseminated infections, including fungemia. T. marneffei oro-pharyngo-laryngitis is an unusual manifestation of talaromycosis. Case presentation A 52-year-old Thai woman had been diagnosed anti-IFNɣ autoantibodies for 4 years. She had a sore throat, odynophagia, and hoarseness for 3 weeks. She also had febrile symptoms and lost 5 kg in weight. Physical examination revealed marked swelling and hyperemia of both sides of the tonsils, the uvula and palatal arches including a swelling of the epiglottis, and arytenoid. The right tonsillar biopsy exhibited a few intracellular oval and elongated yeast-like organisms with some central transverse septum seen, which subsequently grew a few colonies of T. marneffei on fungal cultures. The patient received amphotericin B deoxycholate 45 mg/dayfor 1 weeks, followed by oral itraconazole 400 mg/day for several months. Her symptoms completely resolved without complication. Conclusion In patients with anti-IFN-ɣ autoantibodies, T. marneffei can rarely cause a local infection involving oropharynx and larynx. Fungal culture and pathological examination are warranted for diagnosis T. marneffei oro-pharyngo-laryngitis. This condition requires a long term antifungal therapy. |
| first_indexed | 2024-12-14T16:10:07Z |
| format | Article |
| id | doaj.art-4fe80af6777b48398457ea8474be8dd9 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-14T16:10:07Z |
| publishDate | 2019-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-4fe80af6777b48398457ea8474be8dd92022-12-21T22:55:01ZengBMCBMC Infectious Diseases1471-23342019-12-011911610.1186/s12879-019-4650-7A case report of Talaromyces marneffei Oro-pharyngo-laryngitis: a rare manifestation of TalaromycosisThanyarak Wongkamhla0Piriyaporn Chongtrakool1Anupop Jitmuang2Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDivision of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol UniversityAbstract Background The incidence of Taralomyces marneffei infection in HIV-infected individuals has been decreasing, whereas its rate is rising among non-HIV immunodeficient persons, particularly patients with anti-interferon-gamma autoantibodies. T. marneffei usually causes invasive and disseminated infections, including fungemia. T. marneffei oro-pharyngo-laryngitis is an unusual manifestation of talaromycosis. Case presentation A 52-year-old Thai woman had been diagnosed anti-IFNɣ autoantibodies for 4 years. She had a sore throat, odynophagia, and hoarseness for 3 weeks. She also had febrile symptoms and lost 5 kg in weight. Physical examination revealed marked swelling and hyperemia of both sides of the tonsils, the uvula and palatal arches including a swelling of the epiglottis, and arytenoid. The right tonsillar biopsy exhibited a few intracellular oval and elongated yeast-like organisms with some central transverse septum seen, which subsequently grew a few colonies of T. marneffei on fungal cultures. The patient received amphotericin B deoxycholate 45 mg/dayfor 1 weeks, followed by oral itraconazole 400 mg/day for several months. Her symptoms completely resolved without complication. Conclusion In patients with anti-IFN-ɣ autoantibodies, T. marneffei can rarely cause a local infection involving oropharynx and larynx. Fungal culture and pathological examination are warranted for diagnosis T. marneffei oro-pharyngo-laryngitis. This condition requires a long term antifungal therapy.https://doi.org/10.1186/s12879-019-4650-7Taralomyces marneffeiTalaromycosisOro-pharyngo-laryngitisAnti-interferon-gamma autoantibodies |
| spellingShingle | Thanyarak Wongkamhla Piriyaporn Chongtrakool Anupop Jitmuang A case report of Talaromyces marneffei Oro-pharyngo-laryngitis: a rare manifestation of Talaromycosis BMC Infectious Diseases Taralomyces marneffei Talaromycosis Oro-pharyngo-laryngitis Anti-interferon-gamma autoantibodies |
| title | A case report of Talaromyces marneffei Oro-pharyngo-laryngitis: a rare manifestation of Talaromycosis |
| title_full | A case report of Talaromyces marneffei Oro-pharyngo-laryngitis: a rare manifestation of Talaromycosis |
| title_fullStr | A case report of Talaromyces marneffei Oro-pharyngo-laryngitis: a rare manifestation of Talaromycosis |
| title_full_unstemmed | A case report of Talaromyces marneffei Oro-pharyngo-laryngitis: a rare manifestation of Talaromycosis |
| title_short | A case report of Talaromyces marneffei Oro-pharyngo-laryngitis: a rare manifestation of Talaromycosis |
| title_sort | case report of talaromyces marneffei oro pharyngo laryngitis a rare manifestation of talaromycosis |
| topic | Taralomyces marneffei Talaromycosis Oro-pharyngo-laryngitis Anti-interferon-gamma autoantibodies |
| url | https://doi.org/10.1186/s12879-019-4650-7 |
| work_keys_str_mv | AT thanyarakwongkamhla acasereportoftalaromycesmarneffeioropharyngolaryngitisararemanifestationoftalaromycosis AT piriyapornchongtrakool acasereportoftalaromycesmarneffeioropharyngolaryngitisararemanifestationoftalaromycosis AT anupopjitmuang acasereportoftalaromycesmarneffeioropharyngolaryngitisararemanifestationoftalaromycosis AT thanyarakwongkamhla casereportoftalaromycesmarneffeioropharyngolaryngitisararemanifestationoftalaromycosis AT piriyapornchongtrakool casereportoftalaromycesmarneffeioropharyngolaryngitisararemanifestationoftalaromycosis AT anupopjitmuang casereportoftalaromycesmarneffeioropharyngolaryngitisararemanifestationoftalaromycosis |