Decreasing trend in prostate cancer with high serum prostate-specific antigen levels detected at first prostate-specific antigen-based population screening in Japan
To clarify the recent trends in prostate-specific antigen (PSA) distribution in men in Japan, we analyzed the PSA distributions of men undergoing PSA-based population screening. We summarized the annual individual data of PSA-based population screening in Kanazawa, Japan, from 2000 to 2011, and anal...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-12-01
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| Series: | Asian Journal of Andrology |
| Subjects: | |
| Online Access: | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=6;spage=833;epage=837;aulast=Kitagawa |
| _version_ | 1818535187699466240 |
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| author | Yasuhide Kitagawa Kazuaki Machioka Hiroshi Yaegashi Kazufumi Nakashima Mitsuo Ofude Kouji Izumi Satoru Ueno Yoshifumi Kadono Hiroyuki Konaka Atsushi Mizokami Mikio Namiki |
| author_facet | Yasuhide Kitagawa Kazuaki Machioka Hiroshi Yaegashi Kazufumi Nakashima Mitsuo Ofude Kouji Izumi Satoru Ueno Yoshifumi Kadono Hiroyuki Konaka Atsushi Mizokami Mikio Namiki |
| author_sort | Yasuhide Kitagawa |
| collection | DOAJ |
| description | To clarify the recent trends in prostate-specific antigen (PSA) distribution in men in Japan, we analyzed the PSA distributions of men undergoing PSA-based population screening. We summarized the annual individual data of PSA-based population screening in Kanazawa, Japan, from 2000 to 2011, and analyzed baseline serum PSA values of the participants at the first population screening. Serum PSA distributions were estimated in all participants and those excluding prostate cancer patients according to age. From 2000 to 2011, 19 620 men participated aged 54-69 years old in this screening program. Mean baseline serum PSA level of all participants at the first screening was 2.64 ng ml−1 in 2000, and gradually decreased to approximately 1.30 ng ml−1 in 2006. That of participants excluding prostate cancer patients was 1.46 ng ml−1 in 2000, and there was no remarkable change during the study period. The 95 th percentiles in the participants excluding prostate cancer patients detected at the first population screening of men aged 54-59, 60-64, and 65-69 years old were 2.90, 3.60, and 4.50 ng ml−1 , respectively. After the commencement of population screening, the proportion of prostate cancer patients with high serum PSA levels decreased. However, there were no changes in serum PSA levels in men without prostate cancer. Age-specific PSA reference level of men without prostate cancer in Japan was similar to that in China and Korea. |
| first_indexed | 2024-12-11T18:21:28Z |
| format | Article |
| id | doaj.art-4fe8344537f54c3a95b1be735384f417 |
| institution | Directory Open Access Journal |
| issn | 1008-682X 1745-7262 |
| language | English |
| last_indexed | 2024-12-11T18:21:28Z |
| publishDate | 2014-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj.art-4fe8344537f54c3a95b1be735384f4172022-12-22T00:55:15ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622014-12-0116683383710.4103/1008-682X.135122Decreasing trend in prostate cancer with high serum prostate-specific antigen levels detected at first prostate-specific antigen-based population screening in JapanYasuhide KitagawaKazuaki MachiokaHiroshi YaegashiKazufumi NakashimaMitsuo OfudeKouji IzumiSatoru UenoYoshifumi KadonoHiroyuki KonakaAtsushi MizokamiMikio NamikiTo clarify the recent trends in prostate-specific antigen (PSA) distribution in men in Japan, we analyzed the PSA distributions of men undergoing PSA-based population screening. We summarized the annual individual data of PSA-based population screening in Kanazawa, Japan, from 2000 to 2011, and analyzed baseline serum PSA values of the participants at the first population screening. Serum PSA distributions were estimated in all participants and those excluding prostate cancer patients according to age. From 2000 to 2011, 19 620 men participated aged 54-69 years old in this screening program. Mean baseline serum PSA level of all participants at the first screening was 2.64 ng ml−1 in 2000, and gradually decreased to approximately 1.30 ng ml−1 in 2006. That of participants excluding prostate cancer patients was 1.46 ng ml−1 in 2000, and there was no remarkable change during the study period. The 95 th percentiles in the participants excluding prostate cancer patients detected at the first population screening of men aged 54-59, 60-64, and 65-69 years old were 2.90, 3.60, and 4.50 ng ml−1 , respectively. After the commencement of population screening, the proportion of prostate cancer patients with high serum PSA levels decreased. However, there were no changes in serum PSA levels in men without prostate cancer. Age-specific PSA reference level of men without prostate cancer in Japan was similar to that in China and Korea.http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=6;spage=833;epage=837;aulast=Kitagawaage-specific prostate-specific antigen reference range; prostate cancer; prostate-specific antigen-based population screening; serum prostate-specific antigen distribution |
| spellingShingle | Yasuhide Kitagawa Kazuaki Machioka Hiroshi Yaegashi Kazufumi Nakashima Mitsuo Ofude Kouji Izumi Satoru Ueno Yoshifumi Kadono Hiroyuki Konaka Atsushi Mizokami Mikio Namiki Decreasing trend in prostate cancer with high serum prostate-specific antigen levels detected at first prostate-specific antigen-based population screening in Japan Asian Journal of Andrology age-specific prostate-specific antigen reference range; prostate cancer; prostate-specific antigen-based population screening; serum prostate-specific antigen distribution |
| title | Decreasing trend in prostate cancer with high serum prostate-specific antigen levels detected at first prostate-specific antigen-based population screening in Japan |
| title_full | Decreasing trend in prostate cancer with high serum prostate-specific antigen levels detected at first prostate-specific antigen-based population screening in Japan |
| title_fullStr | Decreasing trend in prostate cancer with high serum prostate-specific antigen levels detected at first prostate-specific antigen-based population screening in Japan |
| title_full_unstemmed | Decreasing trend in prostate cancer with high serum prostate-specific antigen levels detected at first prostate-specific antigen-based population screening in Japan |
| title_short | Decreasing trend in prostate cancer with high serum prostate-specific antigen levels detected at first prostate-specific antigen-based population screening in Japan |
| title_sort | decreasing trend in prostate cancer with high serum prostate specific antigen levels detected at first prostate specific antigen based population screening in japan |
| topic | age-specific prostate-specific antigen reference range; prostate cancer; prostate-specific antigen-based population screening; serum prostate-specific antigen distribution |
| url | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=6;spage=833;epage=837;aulast=Kitagawa |
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