Progress of TP53 Family Gene TP73 and Tumorigenesis
P73 protein is one of the main members of p53 protein family, and its coding gene TP73 is highly homologous to TP53 gene. On one hand, similar to p53, p73 protein is involved in all aspects of cell life. On the other hand, unlike the p53, not only p73 protein plays the role of tumor suppressor in no...
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| Format: | Article |
| Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2021-02-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://html.rhhz.net/ZLFZYJ/html/8578.2021.20.0622.htm |
| _version_ | 1819119840172965888 |
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| author | XU Jie HAO Mu |
| author_facet | XU Jie HAO Mu |
| author_sort | XU Jie |
| collection | DOAJ |
| description | P73 protein is one of the main members of p53 protein family, and its coding gene TP73 is highly homologous to TP53 gene. On one hand, similar to p53, p73 protein is involved in all aspects of cell life. On the other hand, unlike the p53, not only p73 protein plays the role of tumor suppressor in normal cell activities and tumor development, but also the function of p73 protein is no less complex and important than that of p53 protein. Tumorigenesis involves a variety of cellular biological processes, such as apoptosis, autophagy, cell migration and cell metabolism. These normal cellular biological processes are tightly regulated by multiple cellular signaling pathways to maintain homeostasis. Once a carcinogenic abnormality occurs, it will eventually lead to tumorigenesis. Therefore, this paper mainly focuses on the important research results of p73 and tumorigenesis and its unique function different from p53 protein in recent years. |
| first_indexed | 2024-12-22T06:11:10Z |
| format | Article |
| id | doaj.art-4fe97bfd36f9430da0651f42ec29754a |
| institution | Directory Open Access Journal |
| issn | 1000-8578 1000-8578 |
| language | zho |
| last_indexed | 2024-12-22T06:11:10Z |
| publishDate | 2021-02-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-4fe97bfd36f9430da0651f42ec29754a2022-12-21T18:36:14ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85781000-85782021-02-0148218619010.3971/j.issn.1000-8578.2021.20.06228578.2021.20.0622Progress of TP53 Family Gene TP73 and TumorigenesisXU Jie0HAO Mu1National Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300020, ChinaNational Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300020, ChinaP73 protein is one of the main members of p53 protein family, and its coding gene TP73 is highly homologous to TP53 gene. On one hand, similar to p53, p73 protein is involved in all aspects of cell life. On the other hand, unlike the p53, not only p73 protein plays the role of tumor suppressor in normal cell activities and tumor development, but also the function of p73 protein is no less complex and important than that of p53 protein. Tumorigenesis involves a variety of cellular biological processes, such as apoptosis, autophagy, cell migration and cell metabolism. These normal cellular biological processes are tightly regulated by multiple cellular signaling pathways to maintain homeostasis. Once a carcinogenic abnormality occurs, it will eventually lead to tumorigenesis. Therefore, this paper mainly focuses on the important research results of p73 and tumorigenesis and its unique function different from p53 protein in recent years.http://html.rhhz.net/ZLFZYJ/html/8578.2021.20.0622.htmtp73 genetumorigenesisbiological process |
| spellingShingle | XU Jie HAO Mu Progress of TP53 Family Gene TP73 and Tumorigenesis Zhongliu Fangzhi Yanjiu tp73 gene tumorigenesis biological process |
| title | Progress of TP53 Family Gene TP73 and Tumorigenesis |
| title_full | Progress of TP53 Family Gene TP73 and Tumorigenesis |
| title_fullStr | Progress of TP53 Family Gene TP73 and Tumorigenesis |
| title_full_unstemmed | Progress of TP53 Family Gene TP73 and Tumorigenesis |
| title_short | Progress of TP53 Family Gene TP73 and Tumorigenesis |
| title_sort | progress of tp53 family gene tp73 and tumorigenesis |
| topic | tp73 gene tumorigenesis biological process |
| url | http://html.rhhz.net/ZLFZYJ/html/8578.2021.20.0622.htm |
| work_keys_str_mv | AT xujie progressoftp53familygenetp73andtumorigenesis AT haomu progressoftp53familygenetp73andtumorigenesis |