Dual mechanisms of opioid-induced respiratory depression in the inspiratory rhythm-generating network

Dual mechanisms of opioid-induced respiratory depression in the inspiratory rhythm-generating network

The analgesic utility of opioid-based drugs is limited by the life-threatening risk of respiratory depression. Opioid-induced respiratory depression (OIRD), mediated by the μ-opioid receptor (MOR), is characterized by a pronounced decrease in the frequency and regularity of the inspiratory rhythm, w...

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Bibliographic Details
Main Authors: Nathan A Baertsch, Nicholas E Bush, Nicholas J Burgraff, Jan-Marino Ramirez
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
breathing
opioid
rhythm-generation
pre-bӧtzinger complex
Oprm1
respiratory depression
Online Access:https://elifesciences.org/articles/67523

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