Hyperactivation of mTOR and AKT in a cardiac hypertrophy animal model of Friedreich ataxia

Hyperactivation of mTOR and AKT in a cardiac hypertrophy animal model of Friedreich ataxia

Cardiomyopathy is a primary cause of death in Friedreich ataxia (FRDA) patients with defective iron-sulfur cluster (ISC) biogenesis due to loss of functional frataxin and in rare patients with functional loss of other ISC biogenesis factors. The mechanistic target of rapamycin (mTOR) and AKT signali...

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Bibliographic Details
Main Authors: Wing-Hang Tong, Hayden Ollivierre, Audrey Noguchi, Manik C. Ghosh, Danielle A. Springer, Tracey A. Rouault
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Heliyon
Subjects:
Friedreich ataxia
Cardiac hypertrophy
mTOR
AKT
Frataxin
FXN
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844022016590

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