Effects of acute topiramate administration on post-traumatic stress disorder in rats
Purpose: The aim of this study was to investigate the effects of acute systemic topiramate administration on anxiety index and freezing time, plasma estrogen and progesterone levels, and salivary gland immunoglobulin A in a post-traumatic stress disorder rat model. Materials and Methods: A total of...
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| Format: | Article |
| Language: | English |
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Cukurova University
2022-03-01
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| Series: | Cukurova Medical Journal |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/2125907 |
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| author | Mahluga Jafarova Demirkapu Hasan Raci Yananlı Aliye Çelikkol Ahsen Yilmaz Sevil Karabag Furkan Cuma Doğan |
| author_facet | Mahluga Jafarova Demirkapu Hasan Raci Yananlı Aliye Çelikkol Ahsen Yilmaz Sevil Karabag Furkan Cuma Doğan |
| author_sort | Mahluga Jafarova Demirkapu |
| collection | DOAJ |
| description | Purpose: The aim of this study was to investigate the effects of acute systemic topiramate administration on anxiety index and freezing time, plasma estrogen and progesterone levels, and salivary gland immunoglobulin A in a post-traumatic stress disorder rat model.
Materials and Methods: A total of eighteen female Wistar rats used in the study were exposed to predatory odor stress. One week later, saline was administered to the control group and 15 µM and 30 µM topiramate to the treatment groups, after which the animals were exposed to the trauma reminder and their behavior was monitored in the elevated plus maze. At the end of the experiment, blood samples were taken, animals were sacrificed, salivary glands were removed immediately after.
Results: Topiramate suppressed anxiety index and freezing time in rats with post-traumatic stress disorder at both 15 µM and 30 µM doses compared to the control group. A positive correlation was observed between plasma estrogen level and anxiety index in the control group, and topiramate suppressed this correlation in a dose-dependent manner. Topiramate did not change the plasma progesterone level, but suppressed the salivary gland immunoglobulin A level at the low dose.
Conclusion: These findings obtained in our study indicate that topiramate may be effective in the treatment of post-traumatic stress disorder. |
| first_indexed | 2024-04-10T12:43:51Z |
| format | Article |
| id | doaj.art-4fee4e74daf94da2a236e294e000b9e2 |
| institution | Directory Open Access Journal |
| issn | 2602-3040 |
| language | English |
| last_indexed | 2024-04-10T12:43:51Z |
| publishDate | 2022-03-01 |
| publisher | Cukurova University |
| record_format | Article |
| series | Cukurova Medical Journal |
| spelling | doaj.art-4fee4e74daf94da2a236e294e000b9e22023-02-15T16:14:10ZengCukurova UniversityCukurova Medical Journal2602-30402022-03-0147130130910.17826/cumj.103512948Effects of acute topiramate administration on post-traumatic stress disorder in ratsMahluga Jafarova Demirkapu0Hasan Raci Yananlı1Aliye Çelikkol2Ahsen Yilmaz3Sevil Karabag4Furkan Cuma Doğan5TEKIRDAG NAMIK KEMAL UNIVERSITYMARMARA UNIVERSITYTEKİRDAĞ NAMIK KEMAL ÜNİVERSİTESİTEKİRDAĞ NAMIK KEMAL ÜNİVERSİTESİTEKİRDAĞ NAMIK KEMAL ÜNİVERSİTESİTEKİRDAĞ NAMIK KEMAL ÜNİVERSİTESİPurpose: The aim of this study was to investigate the effects of acute systemic topiramate administration on anxiety index and freezing time, plasma estrogen and progesterone levels, and salivary gland immunoglobulin A in a post-traumatic stress disorder rat model. Materials and Methods: A total of eighteen female Wistar rats used in the study were exposed to predatory odor stress. One week later, saline was administered to the control group and 15 µM and 30 µM topiramate to the treatment groups, after which the animals were exposed to the trauma reminder and their behavior was monitored in the elevated plus maze. At the end of the experiment, blood samples were taken, animals were sacrificed, salivary glands were removed immediately after. Results: Topiramate suppressed anxiety index and freezing time in rats with post-traumatic stress disorder at both 15 µM and 30 µM doses compared to the control group. A positive correlation was observed between plasma estrogen level and anxiety index in the control group, and topiramate suppressed this correlation in a dose-dependent manner. Topiramate did not change the plasma progesterone level, but suppressed the salivary gland immunoglobulin A level at the low dose. Conclusion: These findings obtained in our study indicate that topiramate may be effective in the treatment of post-traumatic stress disorder.https://dergipark.org.tr/tr/download/article-file/2125907kaygı indeksiöstrojendonakalma zamanıprogesterontükürük immünoglobulin aanxiety indexestrogenfreezing timeprogesteronesalivary immunoglobulin a |
| spellingShingle | Mahluga Jafarova Demirkapu Hasan Raci Yananlı Aliye Çelikkol Ahsen Yilmaz Sevil Karabag Furkan Cuma Doğan Effects of acute topiramate administration on post-traumatic stress disorder in rats Cukurova Medical Journal kaygı indeksi östrojen donakalma zamanı progesteron tükürük immünoglobulin a anxiety index estrogen freezing time progesterone salivary immunoglobulin a |
| title | Effects of acute topiramate administration on post-traumatic stress disorder in rats |
| title_full | Effects of acute topiramate administration on post-traumatic stress disorder in rats |
| title_fullStr | Effects of acute topiramate administration on post-traumatic stress disorder in rats |
| title_full_unstemmed | Effects of acute topiramate administration on post-traumatic stress disorder in rats |
| title_short | Effects of acute topiramate administration on post-traumatic stress disorder in rats |
| title_sort | effects of acute topiramate administration on post traumatic stress disorder in rats |
| topic | kaygı indeksi östrojen donakalma zamanı progesteron tükürük immünoglobulin a anxiety index estrogen freezing time progesterone salivary immunoglobulin a |
| url | https://dergipark.org.tr/tr/download/article-file/2125907 |
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