Single-molecule theory of enzymatic inhibition
Single molecule approaches demonstrated that enzymatic catalysis is stochastic which could lead to deviations from classical predictions. Here authors rebuild the theory of enzymatic inhibition to show that stochastic fluctuations on the single enzyme level could make inhibitors act as activators.
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-02995-6 |
| _version_ | 1818992554471849984 |
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| author | Tal Robin Shlomi Reuveni Michael Urbakh |
| author_facet | Tal Robin Shlomi Reuveni Michael Urbakh |
| author_sort | Tal Robin |
| collection | DOAJ |
| description | Single molecule approaches demonstrated that enzymatic catalysis is stochastic which could lead to deviations from classical predictions. Here authors rebuild the theory of enzymatic inhibition to show that stochastic fluctuations on the single enzyme level could make inhibitors act as activators. |
| first_indexed | 2024-12-20T20:28:00Z |
| format | Article |
| id | doaj.art-4ff682a5b6ec47f9b1d180b0cef1fdf2 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:28:00Z |
| publishDate | 2018-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4ff682a5b6ec47f9b1d180b0cef1fdf22022-12-21T19:27:25ZengNature PortfolioNature Communications2041-17232018-02-01911910.1038/s41467-018-02995-6Single-molecule theory of enzymatic inhibitionTal Robin0Shlomi Reuveni1Michael Urbakh2School of Chemistry and The Sackler Center for Computational Molecular and Materials Science, Tel Aviv UniversitySchool of Chemistry and The Sackler Center for Computational Molecular and Materials Science, Tel Aviv UniversitySchool of Chemistry and The Sackler Center for Computational Molecular and Materials Science, Tel Aviv UniversitySingle molecule approaches demonstrated that enzymatic catalysis is stochastic which could lead to deviations from classical predictions. Here authors rebuild the theory of enzymatic inhibition to show that stochastic fluctuations on the single enzyme level could make inhibitors act as activators.https://doi.org/10.1038/s41467-018-02995-6 |
| spellingShingle | Tal Robin Shlomi Reuveni Michael Urbakh Single-molecule theory of enzymatic inhibition Nature Communications |
| title | Single-molecule theory of enzymatic inhibition |
| title_full | Single-molecule theory of enzymatic inhibition |
| title_fullStr | Single-molecule theory of enzymatic inhibition |
| title_full_unstemmed | Single-molecule theory of enzymatic inhibition |
| title_short | Single-molecule theory of enzymatic inhibition |
| title_sort | single molecule theory of enzymatic inhibition |
| url | https://doi.org/10.1038/s41467-018-02995-6 |
| work_keys_str_mv | AT talrobin singlemoleculetheoryofenzymaticinhibition AT shlomireuveni singlemoleculetheoryofenzymaticinhibition AT michaelurbakh singlemoleculetheoryofenzymaticinhibition |