Musa acuminate seed extract attenuates the risk of obesity and associated inflammation in obese mice via suppression of PPARγ and MCP-1
Obesity is a severe public health burden and a major component of metabolic syndrome. It is critical to identify treatment medicines for obesity and associated inflammation. We examined the anti-obesity and anti-inflammatory properties of Musa acuminate seeds methanol extract in high-fat diet-induce...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-01-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844022040257 |
| _version_ | 1828043724112789504 |
|---|---|
| author | Sajedul Islam Dipty Rani Bhowmik Sourav Roy Md. Sadikur Rahman Shuvo Rahima Begum Maruful Hasan Mohammad Tohidul Amin AFM Shahid Ud Daula Mohammad Salim Hossain |
| author_facet | Sajedul Islam Dipty Rani Bhowmik Sourav Roy Md. Sadikur Rahman Shuvo Rahima Begum Maruful Hasan Mohammad Tohidul Amin AFM Shahid Ud Daula Mohammad Salim Hossain |
| author_sort | Sajedul Islam |
| collection | DOAJ |
| description | Obesity is a severe public health burden and a major component of metabolic syndrome. It is critical to identify treatment medicines for obesity and associated inflammation. We examined the anti-obesity and anti-inflammatory properties of Musa acuminate seeds methanol extract in high-fat diet-induced obesity. Changes in body weight, Lee index, fat mass accumulation, serum cholesterol, and serum triglyceride were monitored. Alteration in the expression of PPARγ, GLUT4, and MCP-1 at the transcript level in adipose tissue was also studied. After tabulation of our data, a significant reduction (p < 0.05) was recorded for body weight gain, and fat mass accumulation followed by significant changes (p < 0.05) in serum cholesterol, and serum triglyceride levels by the extract. In agreement with the biochemical data, the extract was capable enough (p < 0.05) to reduce the mRNA expression of PPARγ, and MCP-1, confirming the ability of the extract to ameliorate the risk of obesity and obesity-associated inflammation. Moreover, an in-silico study showed the high binding affinity of the reported compounds from M. acuminate like Delphinidin, Umbelliferon with COX-2, PPARγ, and MCP-1, supporting the notion of the risk-reducing potential of M.acuminate for obesity and obesity mediated inflammatory. |
| first_indexed | 2024-04-10T17:46:19Z |
| format | Article |
| id | doaj.art-4ff6a6828f2d4fee9c6c674bd31dcf7f |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-10T17:46:19Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-4ff6a6828f2d4fee9c6c674bd31dcf7f2023-02-03T04:58:49ZengElsevierHeliyon2405-84402023-01-0191e12737Musa acuminate seed extract attenuates the risk of obesity and associated inflammation in obese mice via suppression of PPARγ and MCP-1Sajedul Islam0Dipty Rani Bhowmik1Sourav Roy2Md. Sadikur Rahman Shuvo3Rahima Begum4Maruful Hasan5Mohammad Tohidul Amin6AFM Shahid Ud Daula7Mohammad Salim Hossain8Department of Pharmacy, Noakhali Science and Technology University, Noakhali, 3814, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, Noakhali, 3814, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, Noakhali, 3814, BangladeshDepartment of Microbiology, Noakhali Science and Technology University, Noakhali, 3814, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, Noakhali, 3814, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, Noakhali, 3814, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, Noakhali, 3814, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, Noakhali, 3814, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, Noakhali, 3814, Bangladesh; Corresponding author. Department of Pharmacy, Noakhali Science and Technology University, Noakhali, 3814, Bangladesh.Obesity is a severe public health burden and a major component of metabolic syndrome. It is critical to identify treatment medicines for obesity and associated inflammation. We examined the anti-obesity and anti-inflammatory properties of Musa acuminate seeds methanol extract in high-fat diet-induced obesity. Changes in body weight, Lee index, fat mass accumulation, serum cholesterol, and serum triglyceride were monitored. Alteration in the expression of PPARγ, GLUT4, and MCP-1 at the transcript level in adipose tissue was also studied. After tabulation of our data, a significant reduction (p < 0.05) was recorded for body weight gain, and fat mass accumulation followed by significant changes (p < 0.05) in serum cholesterol, and serum triglyceride levels by the extract. In agreement with the biochemical data, the extract was capable enough (p < 0.05) to reduce the mRNA expression of PPARγ, and MCP-1, confirming the ability of the extract to ameliorate the risk of obesity and obesity-associated inflammation. Moreover, an in-silico study showed the high binding affinity of the reported compounds from M. acuminate like Delphinidin, Umbelliferon with COX-2, PPARγ, and MCP-1, supporting the notion of the risk-reducing potential of M.acuminate for obesity and obesity mediated inflammatory.http://www.sciencedirect.com/science/article/pii/S2405844022040257Musa acuminateCholesterolObesityPPARγMCP-1 |
| spellingShingle | Sajedul Islam Dipty Rani Bhowmik Sourav Roy Md. Sadikur Rahman Shuvo Rahima Begum Maruful Hasan Mohammad Tohidul Amin AFM Shahid Ud Daula Mohammad Salim Hossain Musa acuminate seed extract attenuates the risk of obesity and associated inflammation in obese mice via suppression of PPARγ and MCP-1 Heliyon Musa acuminate Cholesterol Obesity PPARγ MCP-1 |
| title | Musa acuminate seed extract attenuates the risk of obesity and associated inflammation in obese mice via suppression of PPARγ and MCP-1 |
| title_full | Musa acuminate seed extract attenuates the risk of obesity and associated inflammation in obese mice via suppression of PPARγ and MCP-1 |
| title_fullStr | Musa acuminate seed extract attenuates the risk of obesity and associated inflammation in obese mice via suppression of PPARγ and MCP-1 |
| title_full_unstemmed | Musa acuminate seed extract attenuates the risk of obesity and associated inflammation in obese mice via suppression of PPARγ and MCP-1 |
| title_short | Musa acuminate seed extract attenuates the risk of obesity and associated inflammation in obese mice via suppression of PPARγ and MCP-1 |
| title_sort | musa acuminate seed extract attenuates the risk of obesity and associated inflammation in obese mice via suppression of pparγ and mcp 1 |
| topic | Musa acuminate Cholesterol Obesity PPARγ MCP-1 |
| url | http://www.sciencedirect.com/science/article/pii/S2405844022040257 |
| work_keys_str_mv | AT sajedulislam musaacuminateseedextractattenuatestheriskofobesityandassociatedinflammationinobesemiceviasuppressionofppargandmcp1 AT diptyranibhowmik musaacuminateseedextractattenuatestheriskofobesityandassociatedinflammationinobesemiceviasuppressionofppargandmcp1 AT souravroy musaacuminateseedextractattenuatestheriskofobesityandassociatedinflammationinobesemiceviasuppressionofppargandmcp1 AT mdsadikurrahmanshuvo musaacuminateseedextractattenuatestheriskofobesityandassociatedinflammationinobesemiceviasuppressionofppargandmcp1 AT rahimabegum musaacuminateseedextractattenuatestheriskofobesityandassociatedinflammationinobesemiceviasuppressionofppargandmcp1 AT marufulhasan musaacuminateseedextractattenuatestheriskofobesityandassociatedinflammationinobesemiceviasuppressionofppargandmcp1 AT mohammadtohidulamin musaacuminateseedextractattenuatestheriskofobesityandassociatedinflammationinobesemiceviasuppressionofppargandmcp1 AT afmshahiduddaula musaacuminateseedextractattenuatestheriskofobesityandassociatedinflammationinobesemiceviasuppressionofppargandmcp1 AT mohammadsalimhossain musaacuminateseedextractattenuatestheriskofobesityandassociatedinflammationinobesemiceviasuppressionofppargandmcp1 |