Effect of Postoperative Analgesia with the Combination of Dexmedetomidine and Butorphanol after Posterior Spinal Surgery
<p><strong>Background and Objective: </strong>Opioid medications used to be the key method for the pain management after spine surgery; most of the opioids may cause many adverse reactions. The purpose of this research was to observe the role of dexmedetomidine combined with butorp...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Discover STM Publishing Ltd
2021-06-01
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| Series: | BioMedica |
| Online Access: | https://biomedicapk.com/10.51441/BioMedica/5-275 |
| _version_ | 1797629338504396800 |
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| author | Qiaoling Wu You Shang Yanli Bai Yuan-yuan Wu Hao Wang Tu Shen |
| author_facet | Qiaoling Wu You Shang Yanli Bai Yuan-yuan Wu Hao Wang Tu Shen |
| author_sort | Qiaoling Wu |
| collection | DOAJ |
| description | <p><strong>Background and Objective: </strong>Opioid medications used to be the key method for the pain management after spine surgery; most of the opioids may cause many adverse reactions. The purpose of this research was to observe the role of dexmedetomidine combined with butorphanol in the pain management of patients after posterior spinal surgery.<br /><strong>Methods: </strong>This research was conducted in the First Hospital Affiliated to Jinzhou Medical University, China from May 2018 to January 2019. Sixty patients who underwent posterior spinal surgery were equally divided into two groups randomly: Group B who received butorphanol 0.125 mg/kg and Group DB who received dexmedetomidine (DEX) 0.1 μg/kg/hour plus butorphanol 0.125 mg/kg. The patient-controlled analgesia was conducted to deliver a bolus dose of 0.5 ml. followed by an infusion of 2 ml/hour and a lockout time of 15 minutes. Heart rate, mean arterial pressure, respiration rate, pulse oxygen saturation, visual analog scale score (VAS), and Ramsay sedation score were recorded as follows: 1 hour (T1), 2 hours (T2), 6 hours (T3), 12 hours (T4), and 24 hours (T5) post‑surgery. The total number of buttons pressing of patient controlled intravenous analgesia (PCIA) and supplementary analgesic agents was observed and adverse drug reactions and total rate of patient satisfaction were evaluated statistically.<br /><strong>Results:</strong> VAS scores at different intervals in DB group were significantly lower compared with the B group after surgery; while the score of Ramsay sedation was remarkably higher in DB group. The total number of buttons pressing of PCIA was less than that of the B group and the frequency of nausea was notably lower in DB group (p < 0.05). The total rate of satisfaction with analgesia in DB group was higher after surgery.<br /><strong>Conclusion: </strong>DEX could enhance the analgesic effect of butorphanol after posterior spinal surgery with lesser adverse reactions</p> |
| first_indexed | 2024-03-11T10:53:03Z |
| format | Article |
| id | doaj.art-4ff6fd3526034b10aa2e250b62ce52d0 |
| institution | Directory Open Access Journal |
| issn | 2710-3471 |
| language | English |
| last_indexed | 2024-03-11T10:53:03Z |
| publishDate | 2021-06-01 |
| publisher | Discover STM Publishing Ltd |
| record_format | Article |
| series | BioMedica |
| spelling | doaj.art-4ff6fd3526034b10aa2e250b62ce52d02023-11-13T14:11:21ZengDiscover STM Publishing LtdBioMedica2710-34712021-06-0137210510910.51441/BioMedica/5-275Effect of Postoperative Analgesia with the Combination of Dexmedetomidine and Butorphanol after Posterior Spinal SurgeryQiaoling Wu0You Shang1Yanli Bai2Yuan-yuan Wu3Hao Wang4Tu Shen5Department of Anesthesiology, the First Hospital Affiliated to Jinzhou Medical University - China.Department of Anesthesiology, the First Hospital Affiliated to Jinzhou Medical University - China.Department of Anesthesiology, the First Hospital Affiliated to Jinzhou Medical University - China.Department of Anesthesiology, the First Hospital Affiliated to Jinzhou Medical University - China.Department of Anesthesiology, the First Hospital Affiliated to Jinzhou Medical University - China.Department of Anesthesiology, the First Hospital Affiliated to Jinzhou Medical University - China.<p><strong>Background and Objective: </strong>Opioid medications used to be the key method for the pain management after spine surgery; most of the opioids may cause many adverse reactions. The purpose of this research was to observe the role of dexmedetomidine combined with butorphanol in the pain management of patients after posterior spinal surgery.<br /><strong>Methods: </strong>This research was conducted in the First Hospital Affiliated to Jinzhou Medical University, China from May 2018 to January 2019. Sixty patients who underwent posterior spinal surgery were equally divided into two groups randomly: Group B who received butorphanol 0.125 mg/kg and Group DB who received dexmedetomidine (DEX) 0.1 μg/kg/hour plus butorphanol 0.125 mg/kg. The patient-controlled analgesia was conducted to deliver a bolus dose of 0.5 ml. followed by an infusion of 2 ml/hour and a lockout time of 15 minutes. Heart rate, mean arterial pressure, respiration rate, pulse oxygen saturation, visual analog scale score (VAS), and Ramsay sedation score were recorded as follows: 1 hour (T1), 2 hours (T2), 6 hours (T3), 12 hours (T4), and 24 hours (T5) post‑surgery. The total number of buttons pressing of patient controlled intravenous analgesia (PCIA) and supplementary analgesic agents was observed and adverse drug reactions and total rate of patient satisfaction were evaluated statistically.<br /><strong>Results:</strong> VAS scores at different intervals in DB group were significantly lower compared with the B group after surgery; while the score of Ramsay sedation was remarkably higher in DB group. The total number of buttons pressing of PCIA was less than that of the B group and the frequency of nausea was notably lower in DB group (p < 0.05). The total rate of satisfaction with analgesia in DB group was higher after surgery.<br /><strong>Conclusion: </strong>DEX could enhance the analgesic effect of butorphanol after posterior spinal surgery with lesser adverse reactions</p>https://biomedicapk.com/10.51441/BioMedica/5-275 |
| spellingShingle | Qiaoling Wu You Shang Yanli Bai Yuan-yuan Wu Hao Wang Tu Shen Effect of Postoperative Analgesia with the Combination of Dexmedetomidine and Butorphanol after Posterior Spinal Surgery BioMedica |
| title | Effect of Postoperative Analgesia with the Combination of Dexmedetomidine and Butorphanol after Posterior Spinal Surgery |
| title_full | Effect of Postoperative Analgesia with the Combination of Dexmedetomidine and Butorphanol after Posterior Spinal Surgery |
| title_fullStr | Effect of Postoperative Analgesia with the Combination of Dexmedetomidine and Butorphanol after Posterior Spinal Surgery |
| title_full_unstemmed | Effect of Postoperative Analgesia with the Combination of Dexmedetomidine and Butorphanol after Posterior Spinal Surgery |
| title_short | Effect of Postoperative Analgesia with the Combination of Dexmedetomidine and Butorphanol after Posterior Spinal Surgery |
| title_sort | effect of postoperative analgesia with the combination of dexmedetomidine and butorphanol after posterior spinal surgery |
| url | https://biomedicapk.com/10.51441/BioMedica/5-275 |
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