Unusually Aggressive Primary Testicular Diffuse Large B Cell Lymphoma with Post Therapy Extensive Metastasis
Primary Testicular Lymphoma (PTL) is a rare intermediate to high grade tumour, diffuse large cell being the most common type. Unlike nodal Diffuse Large B-Cell Lymphoma (DLBCL), testicular DLBCL has a less aggressive course and better prognosis. Metastasis is uncommon in testicular DLBCL. Commonly...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/8074/17441_CE[Ra1]_F(GH)_PF1(SWAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Primary Testicular Lymphoma (PTL) is a rare intermediate to high grade tumour, diffuse large cell being the most common type. Unlike
nodal Diffuse Large B-Cell Lymphoma (DLBCL), testicular DLBCL has a less aggressive course and better prognosis. Metastasis is
uncommon in testicular DLBCL. Commonly involved sites are contralateral testes, Waldeyer's ring, skin, lung, Central Nervous System
(CNS) and prostate, however the kidneys, liver, bone marrow, pleura and bones are more rarely involved. We report a case of testicular
DLBCL which has metastasized to skin and bone marrow with an aggressive clinical course in a year, in-spite of combined modality of
therapy given to the patient. Bone marrow infiltration is common and well documented with nodal DLBCL, however there is no published
literature for simultaneous bone marrow and skin infiltration in testicular DLBCL till date. Other large studies done in the west have shown
that distinct metastasis is usually common but the median progression-free survival is usually in years. This case stresses on shorter
period of progression after standard treatment protocol in this part of the world, thus highlighting the need for other extensive studies to
define specific treatment protocol for testicular DLBCL. |
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| ISSN: | 2249-782X 0973-709X |