Unusually Aggressive Primary Testicular Diffuse Large B Cell Lymphoma with Post Therapy Extensive Metastasis
Primary Testicular Lymphoma (PTL) is a rare intermediate to high grade tumour, diffuse large cell being the most common type. Unlike nodal Diffuse Large B-Cell Lymphoma (DLBCL), testicular DLBCL has a less aggressive course and better prognosis. Metastasis is uncommon in testicular DLBCL. Commonly...
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JCDR Research and Publications Private Limited
2016-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/8074/17441_CE[Ra1]_F(GH)_PF1(SWAK)_PFA(AK)_PF2(PAG).pdf |
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| author | Shalini Goel Ritesh Sachdev Ishani Mohapatra Smeeta Gajendra Sunil Gupta |
| author_facet | Shalini Goel Ritesh Sachdev Ishani Mohapatra Smeeta Gajendra Sunil Gupta |
| author_sort | Shalini Goel |
| collection | DOAJ |
| description | Primary Testicular Lymphoma (PTL) is a rare intermediate to high grade tumour, diffuse large cell being the most common type. Unlike
nodal Diffuse Large B-Cell Lymphoma (DLBCL), testicular DLBCL has a less aggressive course and better prognosis. Metastasis is
uncommon in testicular DLBCL. Commonly involved sites are contralateral testes, Waldeyer's ring, skin, lung, Central Nervous System
(CNS) and prostate, however the kidneys, liver, bone marrow, pleura and bones are more rarely involved. We report a case of testicular
DLBCL which has metastasized to skin and bone marrow with an aggressive clinical course in a year, in-spite of combined modality of
therapy given to the patient. Bone marrow infiltration is common and well documented with nodal DLBCL, however there is no published
literature for simultaneous bone marrow and skin infiltration in testicular DLBCL till date. Other large studies done in the west have shown
that distinct metastasis is usually common but the median progression-free survival is usually in years. This case stresses on shorter
period of progression after standard treatment protocol in this part of the world, thus highlighting the need for other extensive studies to
define specific treatment protocol for testicular DLBCL. |
| first_indexed | 2024-12-13T02:15:33Z |
| format | Article |
| id | doaj.art-4ff7281c705c44d480be4005f945dc97 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-13T02:15:33Z |
| publishDate | 2016-07-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-4ff7281c705c44d480be4005f945dc972022-12-22T00:02:54ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-07-01107ED01ED0210.7860/JCDR/2016/17441.8074Unusually Aggressive Primary Testicular Diffuse Large B Cell Lymphoma with Post Therapy Extensive MetastasisShalini Goel0Ritesh Sachdev1Ishani Mohapatra2Smeeta Gajendra3Sunil Gupta4Associate Consultant, Department of Pathology and Laboratory Medicine, Medanta- The Medicity Hospital, Sector 38, Gurgaon, India.Senior Consultant, Department of Pathology and Laboratory Medicine, Medanta- The Medicity Hospital, Sector 38, Gurgaon, India.Consultant, Department of Pathology and Laboratory Medicine, Medanta- The Medicity Hospital, Sector 38, Gurgaon, India.Associate Consultant, Department of Pathology and Laboratory Medicine, Medanta- The Medicity Hospital, Sector 38, Gurgaon, India.Associate Consultant, Department of Medical Oncology and Hematology, Medanta- The Medicity Hospital, Sector 38, Gurgaon, India.Primary Testicular Lymphoma (PTL) is a rare intermediate to high grade tumour, diffuse large cell being the most common type. Unlike nodal Diffuse Large B-Cell Lymphoma (DLBCL), testicular DLBCL has a less aggressive course and better prognosis. Metastasis is uncommon in testicular DLBCL. Commonly involved sites are contralateral testes, Waldeyer's ring, skin, lung, Central Nervous System (CNS) and prostate, however the kidneys, liver, bone marrow, pleura and bones are more rarely involved. We report a case of testicular DLBCL which has metastasized to skin and bone marrow with an aggressive clinical course in a year, in-spite of combined modality of therapy given to the patient. Bone marrow infiltration is common and well documented with nodal DLBCL, however there is no published literature for simultaneous bone marrow and skin infiltration in testicular DLBCL till date. Other large studies done in the west have shown that distinct metastasis is usually common but the median progression-free survival is usually in years. This case stresses on shorter period of progression after standard treatment protocol in this part of the world, thus highlighting the need for other extensive studies to define specific treatment protocol for testicular DLBCL.https://jcdr.net/articles/PDF/8074/17441_CE[Ra1]_F(GH)_PF1(SWAK)_PFA(AK)_PF2(PAG).pdfcns metastasislung metastasispositron emission tomography-computed tomography (pet-ct) |
| spellingShingle | Shalini Goel Ritesh Sachdev Ishani Mohapatra Smeeta Gajendra Sunil Gupta Unusually Aggressive Primary Testicular Diffuse Large B Cell Lymphoma with Post Therapy Extensive Metastasis Journal of Clinical and Diagnostic Research cns metastasis lung metastasis positron emission tomography-computed tomography (pet-ct) |
| title | Unusually Aggressive Primary Testicular Diffuse Large B Cell Lymphoma with Post Therapy Extensive Metastasis |
| title_full | Unusually Aggressive Primary Testicular Diffuse Large B Cell Lymphoma with Post Therapy Extensive Metastasis |
| title_fullStr | Unusually Aggressive Primary Testicular Diffuse Large B Cell Lymphoma with Post Therapy Extensive Metastasis |
| title_full_unstemmed | Unusually Aggressive Primary Testicular Diffuse Large B Cell Lymphoma with Post Therapy Extensive Metastasis |
| title_short | Unusually Aggressive Primary Testicular Diffuse Large B Cell Lymphoma with Post Therapy Extensive Metastasis |
| title_sort | unusually aggressive primary testicular diffuse large b cell lymphoma with post therapy extensive metastasis |
| topic | cns metastasis lung metastasis positron emission tomography-computed tomography (pet-ct) |
| url | https://jcdr.net/articles/PDF/8074/17441_CE[Ra1]_F(GH)_PF1(SWAK)_PFA(AK)_PF2(PAG).pdf |
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