Preventing respiratory syncytial virus infections in hospitalized children and adults: should we do better?
Summary: Objective: To compare the burden of nosocomial and community-acquired respiratory syncytial virus (RSV)-associated acute lower respiratory tract infections (ALRIs) in adult and pediatric patients concomitantly admitted to a French tertiary hospital, and to evaluate the effectiveness of exi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-06-01
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| Series: | Infection Prevention in Practice |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590088920300056 |
| _version_ | 1811213150634115072 |
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| author | Pierre Frange Julie Toubiana Perrine Parize Florence Moulin Anne Scemla Marianne Leruez-Ville |
| author_facet | Pierre Frange Julie Toubiana Perrine Parize Florence Moulin Anne Scemla Marianne Leruez-Ville |
| author_sort | Pierre Frange |
| collection | DOAJ |
| description | Summary: Objective: To compare the burden of nosocomial and community-acquired respiratory syncytial virus (RSV)-associated acute lower respiratory tract infections (ALRIs) in adult and pediatric patients concomitantly admitted to a French tertiary hospital, and to evaluate the effectiveness of existing infection control measures. Patients and methods: We prospectively included all adult and pediatric patients admitted to Necker hospital (Paris) between October 2018 and February 2019 with a diagnosis of RSV-associated ALRI. We compared characteristics of ALRIs between patients with community-acquired versus nosocomial infections and, in each group, between children and adults. Results: Community-acquired and nosocomial RSV-associated ALRIs were diagnosed in 229 and 11 inpatients, respectively. The burden of community-acquired infections was higher in children than in adults: 2.1% versus 0.2% of the total number of pediatric and adult inpatients, respectively (p < 0.0001); 4.2% versus 0.2% of the total number of hospitalization days in pediatric and adult units, respectively (p < 0.0001). Compared to inpatients with community-acquired ALRIs, those with nosocomial infections were more frequently adults (45.5% versus 2.6%, p = 0.0005) and subjects with at least one chronic complex condition (100.0% versus 41.0%, p < 0.0001). The total number of hospitalization days due to nosocomial ALRIs was higher in adults than in children (0.32% versus 0.11%, p < 0.0001). Conclusions: Nosocomial RSV-associated ALRIs rarely occurred, suggesting a good effectiveness of our infection control strategy. However, the burden of nosocomial infection was higher in adults than in children, suggesting that education and training of healthcare personnel, patients and visitors about the risk of nosocomial RSV infections should be reinforced in adult wards. Keywords: Respiratory syncytial virus, Prevention, Palivizumab, Nosocomial, Children, Adults |
| first_indexed | 2024-04-12T05:42:03Z |
| format | Article |
| id | doaj.art-4ff90158ac7441ccb2eb9141f1106e0e |
| institution | Directory Open Access Journal |
| issn | 2590-0889 |
| language | English |
| last_indexed | 2024-04-12T05:42:03Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Infection Prevention in Practice |
| spelling | doaj.art-4ff90158ac7441ccb2eb9141f1106e0e2022-12-22T03:45:37ZengElsevierInfection Prevention in Practice2590-08892020-06-0122Preventing respiratory syncytial virus infections in hospitalized children and adults: should we do better?Pierre Frange0Julie Toubiana1Perrine Parize2Florence Moulin3Anne Scemla4Marianne Leruez-Ville5Laboratoire de Microbiologie Clinique, Assistance Publique – Hôpitaux de Paris (AP-HP), Hôpital Necker – Enfants Malades, Paris, France; Institut Imagine, Université de Paris, EHU 7327, Paris, France; Corresponding author. Pierre Frange, Laboratoire de Microbiologie clinique, Hôpital Necker – Enfants Maladies, 149 Rue de Sèvres, 75015, Paris, France. Tel.: +33 1.44.49.49.61; Fax: +33 1.44.49.49.60.Université de Paris, Service de Pédiatrie Générale et Maladies Infectieuses, AP-HP, Hôpital Necker – Enfants Malades, Paris, France; CNR de la Coqueluche et Autres Bordetelloses, Unité « Biodiversité et épidémiologie des Bactéries Pathogènes », Institut Pasteur, Paris, FranceUniversité Paris Descartes, Centre d’Infectiologie Necker-Pasteur, IHU Imagine, AP-HP, Hôpital Necker – Enfants Malades, Paris, FranceService de Réanimation et Surveillance Continue Médico-chirurgicale Pédiatrique, AP-HP, Hôpital Necker Enfants-Malades, Paris, FranceService de Néphrologie – Transplantation, AP-HP, Hôpital Necker-Enfants Malades, Paris, France; RTRS Centaure, Labex Transplantex, Université de Paris, Paris, FranceLaboratoire de Microbiologie Clinique, Assistance Publique – Hôpitaux de Paris (AP-HP), Hôpital Necker – Enfants Malades, Paris, France; Institut Imagine, Université de Paris, EHU 7327, Paris, France; CNR Cytomegalovirus, Laboratoire Associé, 149 Rue de Sèvres, 75015, Paris, FranceSummary: Objective: To compare the burden of nosocomial and community-acquired respiratory syncytial virus (RSV)-associated acute lower respiratory tract infections (ALRIs) in adult and pediatric patients concomitantly admitted to a French tertiary hospital, and to evaluate the effectiveness of existing infection control measures. Patients and methods: We prospectively included all adult and pediatric patients admitted to Necker hospital (Paris) between October 2018 and February 2019 with a diagnosis of RSV-associated ALRI. We compared characteristics of ALRIs between patients with community-acquired versus nosocomial infections and, in each group, between children and adults. Results: Community-acquired and nosocomial RSV-associated ALRIs were diagnosed in 229 and 11 inpatients, respectively. The burden of community-acquired infections was higher in children than in adults: 2.1% versus 0.2% of the total number of pediatric and adult inpatients, respectively (p < 0.0001); 4.2% versus 0.2% of the total number of hospitalization days in pediatric and adult units, respectively (p < 0.0001). Compared to inpatients with community-acquired ALRIs, those with nosocomial infections were more frequently adults (45.5% versus 2.6%, p = 0.0005) and subjects with at least one chronic complex condition (100.0% versus 41.0%, p < 0.0001). The total number of hospitalization days due to nosocomial ALRIs was higher in adults than in children (0.32% versus 0.11%, p < 0.0001). Conclusions: Nosocomial RSV-associated ALRIs rarely occurred, suggesting a good effectiveness of our infection control strategy. However, the burden of nosocomial infection was higher in adults than in children, suggesting that education and training of healthcare personnel, patients and visitors about the risk of nosocomial RSV infections should be reinforced in adult wards. Keywords: Respiratory syncytial virus, Prevention, Palivizumab, Nosocomial, Children, Adultshttp://www.sciencedirect.com/science/article/pii/S2590088920300056 |
| spellingShingle | Pierre Frange Julie Toubiana Perrine Parize Florence Moulin Anne Scemla Marianne Leruez-Ville Preventing respiratory syncytial virus infections in hospitalized children and adults: should we do better? Infection Prevention in Practice |
| title | Preventing respiratory syncytial virus infections in hospitalized children and adults: should we do better? |
| title_full | Preventing respiratory syncytial virus infections in hospitalized children and adults: should we do better? |
| title_fullStr | Preventing respiratory syncytial virus infections in hospitalized children and adults: should we do better? |
| title_full_unstemmed | Preventing respiratory syncytial virus infections in hospitalized children and adults: should we do better? |
| title_short | Preventing respiratory syncytial virus infections in hospitalized children and adults: should we do better? |
| title_sort | preventing respiratory syncytial virus infections in hospitalized children and adults should we do better |
| url | http://www.sciencedirect.com/science/article/pii/S2590088920300056 |
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