Caffeic acid's role in mitigating polycystic ovary syndrome by countering apoptosis and ER stress triggered by oxidative stress
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that affects women of reproductive age, characterized by androgen-induced oxidative stress leading to several metabolic disorders. In this study, we investigated the potential therapeutic effect of caffeic acid on PCOS and its underlyi...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223011186 |
| _version_ | 1797686856485175296 |
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| author | Yi-Fen Chiang I-Cheng Lin Ko-Chieh Huang Hsin-Yuan Chen Mohamed Ali Yun-Ju Huang Shih-Min Hsia |
| author_facet | Yi-Fen Chiang I-Cheng Lin Ko-Chieh Huang Hsin-Yuan Chen Mohamed Ali Yun-Ju Huang Shih-Min Hsia |
| author_sort | Yi-Fen Chiang |
| collection | DOAJ |
| description | Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that affects women of reproductive age, characterized by androgen-induced oxidative stress leading to several metabolic disorders. In this study, we investigated the potential therapeutic effect of caffeic acid on PCOS and its underlying molecular mechanism. We used a human ovarian granulosa cell line (KGN cells) induced by hydrogen peroxide (H2O2) to examine how caffeic acid influences the protein expression of oxidative stress-induced apoptosis-related markers. Our results indicate that caffeic acid significantly inhibits intracellular reactive oxygen species (ROS) generation and safeguards KGN cells against oxidative stress. For the in vivo aspect of our study, female Sprague-Dawley (SD) rats were utilized to induce the PCOS model using dehydroepiandrosterone (DHEA). Caffeic acid was then administered to the rats for a duration of 6 weeks. The outcomes revealed that caffeic acid effectively improved irregular estrous cycles, fasting blood glucose levels, liver function, and lipid profiles in DHEA-induced PCOS rats. Additionally, it mitigated hyperandrogenism, enhanced steroidogenesis enzyme expression, and modulated apoptosis-related protein expression. Our findings strongly suggest that caffeic acid holds promising potential in reducing oxidative stress-induced damage and ameliorating PCOS-related complications by modulating ER stress. |
| first_indexed | 2024-03-12T01:10:40Z |
| format | Article |
| id | doaj.art-4ff9bf6e50164259abffbcb7301ecec8 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-12T01:10:40Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-4ff9bf6e50164259abffbcb7301ecec82023-09-14T04:52:39ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-10-01166115327Caffeic acid's role in mitigating polycystic ovary syndrome by countering apoptosis and ER stress triggered by oxidative stressYi-Fen Chiang0I-Cheng Lin1Ko-Chieh Huang2Hsin-Yuan Chen3Mohamed Ali4Yun-Ju Huang5Shih-Min Hsia6School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, TaiwanSchool of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, TaiwanSchool of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, TaiwanSchool of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, TaiwanClinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, 11566 Cairo, Egypt; Deaprtment of Obstertrics and Gynecology, University of Chicago, 60637 Chicago, IL, USADepartment of Biotechnology and Food Technology, Southern Taiwan University of Science and Technology, Tainan City 710301, TaiwanSchool of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan; Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei 11031, Taiwan; School of Food and Safety, Taipei Medical University, Taipei 11031, Taiwan; Nutrition Research Center, Taipei Medical University Hospital, Taipei 11031, Taiwan; TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei 11031, Taiwan; Corresponding author at: School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan.Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that affects women of reproductive age, characterized by androgen-induced oxidative stress leading to several metabolic disorders. In this study, we investigated the potential therapeutic effect of caffeic acid on PCOS and its underlying molecular mechanism. We used a human ovarian granulosa cell line (KGN cells) induced by hydrogen peroxide (H2O2) to examine how caffeic acid influences the protein expression of oxidative stress-induced apoptosis-related markers. Our results indicate that caffeic acid significantly inhibits intracellular reactive oxygen species (ROS) generation and safeguards KGN cells against oxidative stress. For the in vivo aspect of our study, female Sprague-Dawley (SD) rats were utilized to induce the PCOS model using dehydroepiandrosterone (DHEA). Caffeic acid was then administered to the rats for a duration of 6 weeks. The outcomes revealed that caffeic acid effectively improved irregular estrous cycles, fasting blood glucose levels, liver function, and lipid profiles in DHEA-induced PCOS rats. Additionally, it mitigated hyperandrogenism, enhanced steroidogenesis enzyme expression, and modulated apoptosis-related protein expression. Our findings strongly suggest that caffeic acid holds promising potential in reducing oxidative stress-induced damage and ameliorating PCOS-related complications by modulating ER stress.http://www.sciencedirect.com/science/article/pii/S0753332223011186Polycystic ovary syndrome (PCOS)Caffeic acidHyperandrogenemiaOxidative stress, hypergly-cemiaDehydroepiandrosterone (DHEA) |
| spellingShingle | Yi-Fen Chiang I-Cheng Lin Ko-Chieh Huang Hsin-Yuan Chen Mohamed Ali Yun-Ju Huang Shih-Min Hsia Caffeic acid's role in mitigating polycystic ovary syndrome by countering apoptosis and ER stress triggered by oxidative stress Biomedicine & Pharmacotherapy Polycystic ovary syndrome (PCOS) Caffeic acid Hyperandrogenemia Oxidative stress, hypergly-cemia Dehydroepiandrosterone (DHEA) |
| title | Caffeic acid's role in mitigating polycystic ovary syndrome by countering apoptosis and ER stress triggered by oxidative stress |
| title_full | Caffeic acid's role in mitigating polycystic ovary syndrome by countering apoptosis and ER stress triggered by oxidative stress |
| title_fullStr | Caffeic acid's role in mitigating polycystic ovary syndrome by countering apoptosis and ER stress triggered by oxidative stress |
| title_full_unstemmed | Caffeic acid's role in mitigating polycystic ovary syndrome by countering apoptosis and ER stress triggered by oxidative stress |
| title_short | Caffeic acid's role in mitigating polycystic ovary syndrome by countering apoptosis and ER stress triggered by oxidative stress |
| title_sort | caffeic acid s role in mitigating polycystic ovary syndrome by countering apoptosis and er stress triggered by oxidative stress |
| topic | Polycystic ovary syndrome (PCOS) Caffeic acid Hyperandrogenemia Oxidative stress, hypergly-cemia Dehydroepiandrosterone (DHEA) |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223011186 |
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