Attribution of Ghrelin to Cancer; Attempts to Unravel an Apparent Controversy
Ghrelin is an endogenous peptide hormone mainly produced in the stomach. It has been known to regulate energy homeostasis, stimulate secretion of growth hormone, and mediate many other physiologic effects. Various effects attributed to ghrelin contribute to many aspects of cancer development and pro...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-10-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2019.01014/full |
| _version_ | 1819017027420946432 |
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| author | Saeed Soleyman-Jahi Saeed Soleyman-Jahi Saeed Soleyman-Jahi Fatemeh Sadeghi Fatemeh Sadeghi Fatemeh Sadeghi Amin Pastaki Khoshbin Amin Pastaki Khoshbin Leila Khani Venus Roosta Kazem Zendehdel |
| author_facet | Saeed Soleyman-Jahi Saeed Soleyman-Jahi Saeed Soleyman-Jahi Fatemeh Sadeghi Fatemeh Sadeghi Fatemeh Sadeghi Amin Pastaki Khoshbin Amin Pastaki Khoshbin Leila Khani Venus Roosta Kazem Zendehdel |
| author_sort | Saeed Soleyman-Jahi |
| collection | DOAJ |
| description | Ghrelin is an endogenous peptide hormone mainly produced in the stomach. It has been known to regulate energy homeostasis, stimulate secretion of growth hormone, and mediate many other physiologic effects. Various effects attributed to ghrelin contribute to many aspects of cancer development and progression. Accordingly, a large body of evidence has emerged about the association of ghrelin with several types of cancer in scales of cell-line, animal, and human studies. However, existing data are controversial. This controversy occurs in two main domains: one is the controversial results in local effects of ghrelin on different types of human cancer cell-lines; the second is the apparent disagreement in the results of in-vitro and clinical studies that investigated ghrelin association to one type of cancer. These inconsistencies have hampered the indications to consider ghrelin as a potential tumor biomarker or therapeutic agent in cancer patients. Previous studies have reviewed different parts of current literature about the ghrelin-cancer relationship. Although they have highlighted these controversial results in various ways, no specific recommendations have been given to address it. In this study, we comprehensively reviewed in-vitro, in-vivo, and clinical studies and attempted to use the following approaches to unravel the inconsistencies detected: (a) to distinguish local and systemic effects of ghrelin in interpreting its summary clinical role in each cancer; (b) scrutinizing factors that regulate local effects of ghrelin and could justify different effects of ghrelin on different cancer cell-lines. These approaches could have notable implications for future in-vitro and clinical studies. |
| first_indexed | 2024-12-21T02:57:00Z |
| format | Article |
| id | doaj.art-4ff9c85584584ce586102b6497239205 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-21T02:57:00Z |
| publishDate | 2019-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-4ff9c85584584ce586102b64972392052022-12-21T19:18:18ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2019-10-01910.3389/fonc.2019.01014480975Attribution of Ghrelin to Cancer; Attempts to Unravel an Apparent ControversySaeed Soleyman-Jahi0Saeed Soleyman-Jahi1Saeed Soleyman-Jahi2Fatemeh Sadeghi3Fatemeh Sadeghi4Fatemeh Sadeghi5Amin Pastaki Khoshbin6Amin Pastaki Khoshbin7Leila Khani8Venus Roosta9Kazem Zendehdel10Division of Gastroenterology, School of Medicine, Washington University in St. Louis, St. Louis, MO, United StatesCancer Immunology Project, Universal Scientific Education and Research Network, St. Louis, MO, United StatesCancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, IranCancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, IranCancer Immunology Project, Universal Scientific Education and Research Network, Tehran, IranDepartment of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, IranCancer Immunology Project, Universal Scientific Education and Research Network, Tehran, IranSchool of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, IranSchool of Medicine, Tehran University of Medical Sciences, Tehran, IranCancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, IranGhrelin is an endogenous peptide hormone mainly produced in the stomach. It has been known to regulate energy homeostasis, stimulate secretion of growth hormone, and mediate many other physiologic effects. Various effects attributed to ghrelin contribute to many aspects of cancer development and progression. Accordingly, a large body of evidence has emerged about the association of ghrelin with several types of cancer in scales of cell-line, animal, and human studies. However, existing data are controversial. This controversy occurs in two main domains: one is the controversial results in local effects of ghrelin on different types of human cancer cell-lines; the second is the apparent disagreement in the results of in-vitro and clinical studies that investigated ghrelin association to one type of cancer. These inconsistencies have hampered the indications to consider ghrelin as a potential tumor biomarker or therapeutic agent in cancer patients. Previous studies have reviewed different parts of current literature about the ghrelin-cancer relationship. Although they have highlighted these controversial results in various ways, no specific recommendations have been given to address it. In this study, we comprehensively reviewed in-vitro, in-vivo, and clinical studies and attempted to use the following approaches to unravel the inconsistencies detected: (a) to distinguish local and systemic effects of ghrelin in interpreting its summary clinical role in each cancer; (b) scrutinizing factors that regulate local effects of ghrelin and could justify different effects of ghrelin on different cancer cell-lines. These approaches could have notable implications for future in-vitro and clinical studies.https://www.frontiersin.org/article/10.3389/fonc.2019.01014/fullghrelincancercarcinogenesisprognosisorexigenic |
| spellingShingle | Saeed Soleyman-Jahi Saeed Soleyman-Jahi Saeed Soleyman-Jahi Fatemeh Sadeghi Fatemeh Sadeghi Fatemeh Sadeghi Amin Pastaki Khoshbin Amin Pastaki Khoshbin Leila Khani Venus Roosta Kazem Zendehdel Attribution of Ghrelin to Cancer; Attempts to Unravel an Apparent Controversy Frontiers in Oncology ghrelin cancer carcinogenesis prognosis orexigenic |
| title | Attribution of Ghrelin to Cancer; Attempts to Unravel an Apparent Controversy |
| title_full | Attribution of Ghrelin to Cancer; Attempts to Unravel an Apparent Controversy |
| title_fullStr | Attribution of Ghrelin to Cancer; Attempts to Unravel an Apparent Controversy |
| title_full_unstemmed | Attribution of Ghrelin to Cancer; Attempts to Unravel an Apparent Controversy |
| title_short | Attribution of Ghrelin to Cancer; Attempts to Unravel an Apparent Controversy |
| title_sort | attribution of ghrelin to cancer attempts to unravel an apparent controversy |
| topic | ghrelin cancer carcinogenesis prognosis orexigenic |
| url | https://www.frontiersin.org/article/10.3389/fonc.2019.01014/full |
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