Association of Persistent Symptoms after Lyme Neuroborreliosis and Increased Levels of Interferon-α in Blood
Patients who have Lyme neuroborreliosis (LNB) might experience lingering symptoms that persist despite antibiotic drug therapy. We tested whether those symptoms are caused by maladaptive immune responses by measuring 20 immune mediators in serum and cerebrospinal fluid (CSF) in 79 LNB patients foll...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2023-06-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/29/6/22-1685_article |
| _version_ | 1797823556447371264 |
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| author | Sergio A. Hernández Katarina Ogrinc Miša Korva Andrej Kastrin Petra Bogovič Tereza Rojko Keith W. Kelley Janis J. Weis Franc Strle Klemen Strle |
| author_facet | Sergio A. Hernández Katarina Ogrinc Miša Korva Andrej Kastrin Petra Bogovič Tereza Rojko Keith W. Kelley Janis J. Weis Franc Strle Klemen Strle |
| author_sort | Sergio A. Hernández |
| collection | DOAJ |
| description |
Patients who have Lyme neuroborreliosis (LNB) might experience lingering symptoms that persist despite antibiotic drug therapy. We tested whether those symptoms are caused by maladaptive immune responses by measuring 20 immune mediators in serum and cerebrospinal fluid (CSF) in 79 LNB patients followed for 1 year. At study entry, most mediators were highly concentrated in CSF, the site of the infection. Those responses resolved with antibiotic therapy, and associations between CSF cytokines and signs and symptoms of LNB were no longer observed. In contrast, subjective symptoms that persisted after use of antibiotics were associated with increased levels of serum interferon-α (IFN-α), which were already observed at study entry, and remained increased at each subsequent timepoint. Highest IFN-α levels corresponded with severe disease. Although the infection serves as the initial trigger, sequelae after antibiotic therapy are associated with unremitting systemic IFN-α levels, consistent with the pathogenic role of this cytokine in interferonopathies in other conditions.
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| first_indexed | 2024-03-13T10:25:40Z |
| format | Article |
| id | doaj.art-4ffc9c3c8ef34effa218f0f7b8bb57cb |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-03-13T10:25:40Z |
| publishDate | 2023-06-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-4ffc9c3c8ef34effa218f0f7b8bb57cb2023-05-19T12:22:55ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592023-06-012961091110110.3201/eid2906.221685Association of Persistent Symptoms after Lyme Neuroborreliosis and Increased Levels of Interferon-α in BloodSergio A. HernándezKatarina OgrincMiša KorvaAndrej KastrinPetra BogovičTereza RojkoKeith W. KelleyJanis J. WeisFranc StrleKlemen Strle Patients who have Lyme neuroborreliosis (LNB) might experience lingering symptoms that persist despite antibiotic drug therapy. We tested whether those symptoms are caused by maladaptive immune responses by measuring 20 immune mediators in serum and cerebrospinal fluid (CSF) in 79 LNB patients followed for 1 year. At study entry, most mediators were highly concentrated in CSF, the site of the infection. Those responses resolved with antibiotic therapy, and associations between CSF cytokines and signs and symptoms of LNB were no longer observed. In contrast, subjective symptoms that persisted after use of antibiotics were associated with increased levels of serum interferon-α (IFN-α), which were already observed at study entry, and remained increased at each subsequent timepoint. Highest IFN-α levels corresponded with severe disease. Although the infection serves as the initial trigger, sequelae after antibiotic therapy are associated with unremitting systemic IFN-α levels, consistent with the pathogenic role of this cytokine in interferonopathies in other conditions. https://wwwnc.cdc.gov/eid/article/29/6/22-1685_articleLyme neuroborreliosispersistent symptomsLyme diseaseimmune responseinflammationinterferon-alpha |
| spellingShingle | Sergio A. Hernández Katarina Ogrinc Miša Korva Andrej Kastrin Petra Bogovič Tereza Rojko Keith W. Kelley Janis J. Weis Franc Strle Klemen Strle Association of Persistent Symptoms after Lyme Neuroborreliosis and Increased Levels of Interferon-α in Blood Emerging Infectious Diseases Lyme neuroborreliosis persistent symptoms Lyme disease immune response inflammation interferon-alpha |
| title | Association of Persistent Symptoms after Lyme Neuroborreliosis and Increased Levels of Interferon-α in Blood |
| title_full | Association of Persistent Symptoms after Lyme Neuroborreliosis and Increased Levels of Interferon-α in Blood |
| title_fullStr | Association of Persistent Symptoms after Lyme Neuroborreliosis and Increased Levels of Interferon-α in Blood |
| title_full_unstemmed | Association of Persistent Symptoms after Lyme Neuroborreliosis and Increased Levels of Interferon-α in Blood |
| title_short | Association of Persistent Symptoms after Lyme Neuroborreliosis and Increased Levels of Interferon-α in Blood |
| title_sort | association of persistent symptoms after lyme neuroborreliosis and increased levels of interferon α in blood |
| topic | Lyme neuroborreliosis persistent symptoms Lyme disease immune response inflammation interferon-alpha |
| url | https://wwwnc.cdc.gov/eid/article/29/6/22-1685_article |
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