Radotinib Decreases Prion Propagation and Prolongs Survival Times in Models of Prion Disease

Radotinib Decreases Prion Propagation and Prolongs Survival Times in Models of Prion Disease

The conversion of cellular prion protein (PrP<sup>C</sup>) into pathogenic prion isoforms (PrP<sup>Sc</sup>) and the mutation of <i>PRNP</i> are definite causes of prion diseases. Unfortunately, without exception, prion diseases are untreatable and fatal neurodege...

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Main Authors: Yeong-Gon Choi, Byungki Jang, Jeong-Ho Park, Min-Woo Choi, Gong Yeal Lee, Dae Jin Cho, Hong Youp Kim, Hae Kyoung Lim, Won Jae Lee, Eun-Kyoung Choi, Yong-Sun Kim
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
radotinib
prion
drug repositioning
neurodegeneration
Online Access:https://www.mdpi.com/1422-0067/24/15/12241

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