Drosophila melanogaster as a model for unraveling unique molecular features of epilepsy elicited by human GABA transporter 1 variants
Mutations in the human γ-aminobutyric acid (GABA) transporter 1 (hGAT-1) can instigate myoclonic-atonic and other generalized epilepsies in the afflicted individuals. We systematically examined fifteen hGAT-1 disease variants, all of which dramatically reduced or completely abolished GABA uptake act...
| Main Authors: | , , , , , , , |
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| 格式: | 文件 |
| 语言: | English |
| 出版: |
Frontiers Media S.A.
2023-01-01
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| 丛编: | Frontiers in Neuroscience |
| 主题: | |
| 在线阅读: | https://www.frontiersin.org/articles/10.3389/fnins.2022.1074427/full |