Glycated Hemoglobin (HbA1c) Concentrations Among Children and Adolescents With Diabetes in Middle- and Low-Income Countries, 2010–2019: A Retrospective Chart Review and Systematic Review of Literature
ObjectivesTo explore the glycemic control [represented by glycated hemoglobin (HbA1c) concentrations] in children with diabetes mellitus (DM) in east China and middle- and low-income countries, from 2010 to 2019.MethodsRetrospective data of children with DM from two hospital-based health records wer...
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.651589/full |
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| author | Xiuli Chen Zhou Pei Miaoying Zhang Zhenran Xu Zhuhui Zhao Wei Lu Linqi Chen Feihong Luo Ting Chen Chengjun Sun |
| author_facet | Xiuli Chen Zhou Pei Miaoying Zhang Zhenran Xu Zhuhui Zhao Wei Lu Linqi Chen Feihong Luo Ting Chen Chengjun Sun |
| author_sort | Xiuli Chen |
| collection | DOAJ |
| description | ObjectivesTo explore the glycemic control [represented by glycated hemoglobin (HbA1c) concentrations] in children with diabetes mellitus (DM) in east China and middle- and low-income countries, from 2010 to 2019.MethodsRetrospective data of children with DM from two hospital-based health records were reviewed. Data on HbA1c concentrations, hospitalization due to diabetic ketoacidosis, and patient demographics were collected and analyzed. A systematic review was subsequently performed to analyze publications that report HbA1c concentrations in patients aged <18 years. Patients’ characteristics extracted from each publication were used to generate simulated individual data for pooled analysis. HbA1c estimates were derived from steady-state iterations.ResultsData of 843 diabetic children (aged 11.2 ± 3.9 years) with 2,658 HbA1c measures were retrieved from the two hospitals during the period 2010–2020. The duration of diabetes in the patients was 4.4 ± 2.8 years, and their HbA1c was 8.1 ± 2.2%. Patients who were internal migrants had significantly higher HbA1c concentration than resident patients (8.4 vs. 7.9%). The literature review yielded 1,164 publications, and the majority (74.1%) of patient data were published in high-income countries. The patient data extracted from these publications generated 486,416 HbA1c concentration estimates between 2005 and 2019. The average HbA1c concentration during the 15 years was 9.07 ± 2.15%. The mean HbA1c concentrations among children were 8.23, 8.73, 9.20, and 10.11% in high-income country (HIC), upper-middle income country (UMIC), lower-middle income country (LMIC), and low-income country (LIC) respectively. The mean rate of optimized glycemic control (HbA1c <7.5%) among children was 32.4, 27.5, 21.7, and 12.7% in HIC, UMIC, LMIC, and LIC, respectively.ConclusionsThe current study indicated that there is substantial room for improvement in glycemic control in children with DM worldwide, especially in middle- and low-income countries. |
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| id | doaj.art-50016161815849aabd8f8f64c809260b |
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| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-22T07:07:42Z |
| publishDate | 2021-04-01 |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-50016161815849aabd8f8f64c809260b2022-12-21T18:34:37ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-04-011210.3389/fendo.2021.651589651589Glycated Hemoglobin (HbA1c) Concentrations Among Children and Adolescents With Diabetes in Middle- and Low-Income Countries, 2010–2019: A Retrospective Chart Review and Systematic Review of LiteratureXiuli Chen0Zhou Pei1Miaoying Zhang2Zhenran Xu3Zhuhui Zhao4Wei Lu5Linqi Chen6Feihong Luo7Ting Chen8Chengjun Sun9Department of Endocrinology, Genetics and Metabolism, Children’s Hospital of Soochow University, Suzhou, ChinaDepartment of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan University, Shanghai, ChinaDepartment of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan University, Shanghai, ChinaDepartment of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan University, Shanghai, ChinaDepartment of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan University, Shanghai, ChinaDepartment of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan University, Shanghai, ChinaDepartment of Endocrinology, Genetics and Metabolism, Children’s Hospital of Soochow University, Suzhou, ChinaDepartment of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan University, Shanghai, ChinaDepartment of Endocrinology, Genetics and Metabolism, Children’s Hospital of Soochow University, Suzhou, ChinaDepartment of Pediatric Endocrinology and Inherited Metabolic Diseases, Children’s Hospital of Fudan University, Shanghai, ChinaObjectivesTo explore the glycemic control [represented by glycated hemoglobin (HbA1c) concentrations] in children with diabetes mellitus (DM) in east China and middle- and low-income countries, from 2010 to 2019.MethodsRetrospective data of children with DM from two hospital-based health records were reviewed. Data on HbA1c concentrations, hospitalization due to diabetic ketoacidosis, and patient demographics were collected and analyzed. A systematic review was subsequently performed to analyze publications that report HbA1c concentrations in patients aged <18 years. Patients’ characteristics extracted from each publication were used to generate simulated individual data for pooled analysis. HbA1c estimates were derived from steady-state iterations.ResultsData of 843 diabetic children (aged 11.2 ± 3.9 years) with 2,658 HbA1c measures were retrieved from the two hospitals during the period 2010–2020. The duration of diabetes in the patients was 4.4 ± 2.8 years, and their HbA1c was 8.1 ± 2.2%. Patients who were internal migrants had significantly higher HbA1c concentration than resident patients (8.4 vs. 7.9%). The literature review yielded 1,164 publications, and the majority (74.1%) of patient data were published in high-income countries. The patient data extracted from these publications generated 486,416 HbA1c concentration estimates between 2005 and 2019. The average HbA1c concentration during the 15 years was 9.07 ± 2.15%. The mean HbA1c concentrations among children were 8.23, 8.73, 9.20, and 10.11% in high-income country (HIC), upper-middle income country (UMIC), lower-middle income country (LMIC), and low-income country (LIC) respectively. The mean rate of optimized glycemic control (HbA1c <7.5%) among children was 32.4, 27.5, 21.7, and 12.7% in HIC, UMIC, LMIC, and LIC, respectively.ConclusionsThe current study indicated that there is substantial room for improvement in glycemic control in children with DM worldwide, especially in middle- and low-income countries.https://www.frontiersin.org/articles/10.3389/fendo.2021.651589/fullglycemic controldiabetes mellituschildhoodHbA1cmiddle- and low-income country |
| spellingShingle | Xiuli Chen Zhou Pei Miaoying Zhang Zhenran Xu Zhuhui Zhao Wei Lu Linqi Chen Feihong Luo Ting Chen Chengjun Sun Glycated Hemoglobin (HbA1c) Concentrations Among Children and Adolescents With Diabetes in Middle- and Low-Income Countries, 2010–2019: A Retrospective Chart Review and Systematic Review of Literature Frontiers in Endocrinology glycemic control diabetes mellitus childhood HbA1c middle- and low-income country |
| title | Glycated Hemoglobin (HbA1c) Concentrations Among Children and Adolescents With Diabetes in Middle- and Low-Income Countries, 2010–2019: A Retrospective Chart Review and Systematic Review of Literature |
| title_full | Glycated Hemoglobin (HbA1c) Concentrations Among Children and Adolescents With Diabetes in Middle- and Low-Income Countries, 2010–2019: A Retrospective Chart Review and Systematic Review of Literature |
| title_fullStr | Glycated Hemoglobin (HbA1c) Concentrations Among Children and Adolescents With Diabetes in Middle- and Low-Income Countries, 2010–2019: A Retrospective Chart Review and Systematic Review of Literature |
| title_full_unstemmed | Glycated Hemoglobin (HbA1c) Concentrations Among Children and Adolescents With Diabetes in Middle- and Low-Income Countries, 2010–2019: A Retrospective Chart Review and Systematic Review of Literature |
| title_short | Glycated Hemoglobin (HbA1c) Concentrations Among Children and Adolescents With Diabetes in Middle- and Low-Income Countries, 2010–2019: A Retrospective Chart Review and Systematic Review of Literature |
| title_sort | glycated hemoglobin hba1c concentrations among children and adolescents with diabetes in middle and low income countries 2010 2019 a retrospective chart review and systematic review of literature |
| topic | glycemic control diabetes mellitus childhood HbA1c middle- and low-income country |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.651589/full |
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