Associations of General and Abdominal Obesity with the Risk of Glioma Development
The association between obesity and the risk of glioma remains unclear. We sought to evaluate the potential association between general and abdominal obesity and the risk of glioma based on a nationwide population-based cohort study of Koreans. Using data from the Korean National Health Insurance Sy...
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MDPI AG
2021-06-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/12/2859 |
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| author | Stephen Ahn Kyungdo Han Jung-Eun Lee Sin-Soo Jeun Yong-Moon Park Seung Ho Yang |
| author_facet | Stephen Ahn Kyungdo Han Jung-Eun Lee Sin-Soo Jeun Yong-Moon Park Seung Ho Yang |
| author_sort | Stephen Ahn |
| collection | DOAJ |
| description | The association between obesity and the risk of glioma remains unclear. We sought to evaluate the potential association between general and abdominal obesity and the risk of glioma based on a nationwide population-based cohort study of Koreans. Using data from the Korean National Health Insurance System cohort, 6,833,744 people older than 20 years who underwent regular national health examination in both 2009 and 2011 were followed until the end of 2017. We documented 4771 glioma cases based on an ICD-10 code of C71 during the median follow-up period of 7.30 years. Individuals with a body mass index (BMI) ≥ 25.0 kg/m<sup>2</sup> were at significantly higher risk of developing glioma than those with a BMI < 25.0 kg/m<sup>2</sup> (HR 1.08 CI 1.02–1.15). Individuals with a waist circumference (WC) ≥ 90 cm (males)/85 cm (females) also had a significantly higher risk of glioma than those with a WC < 90 cm (males)/85 cm (females) (HR 1.16 CI 1.09–1.24). In the group with a BMI ≥ 25.0 kg/m<sup>2</sup>, individuals with abdominal obesity were at significantly higher risk of developing glioma (HR 1.18 CI 1.09–1.27) than those without abdominal obesity. The role of abdominal obesity in this association was stronger in women than in men. To the best of our knowledge, this is the first demonstration that obese people may be at higher risk of glioma, especially centrally obese people from an Asian population with a BMI ≥ 25.0 kg/m<sup>2</sup>. Loss of visceral fat in people with abdominal obesity may reduce their risk of developing glioma. |
| first_indexed | 2024-03-10T10:37:02Z |
| format | Article |
| id | doaj.art-5002b6fcba544205aea70d17bb3c7f07 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T10:37:02Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5002b6fcba544205aea70d17bb3c7f072023-11-21T23:13:13ZengMDPI AGCancers2072-66942021-06-011312285910.3390/cancers13122859Associations of General and Abdominal Obesity with the Risk of Glioma DevelopmentStephen Ahn0Kyungdo Han1Jung-Eun Lee2Sin-Soo Jeun3Yong-Moon Park4Seung Ho Yang5Department of Neurosurgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Statistics and Actuarial Science, Soongsil University, Seoul 06978, KoreaDepartment of Neurosurgery, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Neurosurgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USADepartment of Neurosurgery, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaThe association between obesity and the risk of glioma remains unclear. We sought to evaluate the potential association between general and abdominal obesity and the risk of glioma based on a nationwide population-based cohort study of Koreans. Using data from the Korean National Health Insurance System cohort, 6,833,744 people older than 20 years who underwent regular national health examination in both 2009 and 2011 were followed until the end of 2017. We documented 4771 glioma cases based on an ICD-10 code of C71 during the median follow-up period of 7.30 years. Individuals with a body mass index (BMI) ≥ 25.0 kg/m<sup>2</sup> were at significantly higher risk of developing glioma than those with a BMI < 25.0 kg/m<sup>2</sup> (HR 1.08 CI 1.02–1.15). Individuals with a waist circumference (WC) ≥ 90 cm (males)/85 cm (females) also had a significantly higher risk of glioma than those with a WC < 90 cm (males)/85 cm (females) (HR 1.16 CI 1.09–1.24). In the group with a BMI ≥ 25.0 kg/m<sup>2</sup>, individuals with abdominal obesity were at significantly higher risk of developing glioma (HR 1.18 CI 1.09–1.27) than those without abdominal obesity. The role of abdominal obesity in this association was stronger in women than in men. To the best of our knowledge, this is the first demonstration that obese people may be at higher risk of glioma, especially centrally obese people from an Asian population with a BMI ≥ 25.0 kg/m<sup>2</sup>. Loss of visceral fat in people with abdominal obesity may reduce their risk of developing glioma.https://www.mdpi.com/2072-6694/13/12/2859waist circumstanceobesityabdominal obesitygliomarisk factors |
| spellingShingle | Stephen Ahn Kyungdo Han Jung-Eun Lee Sin-Soo Jeun Yong-Moon Park Seung Ho Yang Associations of General and Abdominal Obesity with the Risk of Glioma Development Cancers waist circumstance obesity abdominal obesity glioma risk factors |
| title | Associations of General and Abdominal Obesity with the Risk of Glioma Development |
| title_full | Associations of General and Abdominal Obesity with the Risk of Glioma Development |
| title_fullStr | Associations of General and Abdominal Obesity with the Risk of Glioma Development |
| title_full_unstemmed | Associations of General and Abdominal Obesity with the Risk of Glioma Development |
| title_short | Associations of General and Abdominal Obesity with the Risk of Glioma Development |
| title_sort | associations of general and abdominal obesity with the risk of glioma development |
| topic | waist circumstance obesity abdominal obesity glioma risk factors |
| url | https://www.mdpi.com/2072-6694/13/12/2859 |
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