Environmental and sociocultural factors are associated with pain-related brain structure among diverse individuals with chronic musculoskeletal pain: intersectional considerations
Abstract Chronic musculoskeletal pain including knee osteoarthritis (OA) is a leading cause of disability worldwide. Previous research indicates ethnic-race groups differ in the pain and functional limitations experienced with knee OA. However, when socioenvironmental factors are included in analyse...
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| Format: | Article |
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Nature Portfolio
2024-04-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-58120-9 |
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| author | Lisa H. Domenico Jared J. Tanner Angela M. Mickle Ellen L. Terry Cynthia Garvan Song Lai Hrishikesh Deshpande Roland Staud David Redden Catherine C. Price Burel R. Goodin Roger B. Fillingim Kimberly T. Sibille |
| author_facet | Lisa H. Domenico Jared J. Tanner Angela M. Mickle Ellen L. Terry Cynthia Garvan Song Lai Hrishikesh Deshpande Roland Staud David Redden Catherine C. Price Burel R. Goodin Roger B. Fillingim Kimberly T. Sibille |
| author_sort | Lisa H. Domenico |
| collection | DOAJ |
| description | Abstract Chronic musculoskeletal pain including knee osteoarthritis (OA) is a leading cause of disability worldwide. Previous research indicates ethnic-race groups differ in the pain and functional limitations experienced with knee OA. However, when socioenvironmental factors are included in analyses, group differences in pain and function wane. Pain-related brain structures are another area where ethnic-race group differences have been observed. Environmental and sociocultural factors e.g., income, education, experiences of discrimination, and social support influence brain structures. We investigate if environmental and sociocultural factors reduce previously observed ethnic-race group differences in pain-related brain structures. Data were analyzed from 147 self-identified non-Hispanic black (NHB) and non-Hispanic white (NHW), middle and older aged adults with knee pain in the past month. Information collected included health and pain history, environmental and sociocultural resources, and brain imaging. The NHB adults were younger and reported lower income and education compared to their NHW peers. In hierarchical multiple regression models, sociocultural and environmental factors explained 6–37% of the variance in pain-related brain regions. Self-identified ethnicity-race provided an additional 4–13% of explanatory value in the amygdala, hippocampus, insula, bilateral primary somatosensory cortex, and thalamus. In the rostral/caudal anterior cingulate and dorsolateral prefrontal cortex, self-identified ethnicity-race was not a predictor after accounting for environmental, sociocultural, and demographic factors. Findings help to disentangle and identify some of the factors contributing to ethnic-race group disparities in pain-related brain structures. Numerous arrays of environmental and sociocultural factors remain to be investigated. Further, the differing sociodemographic representation of our NHB and NHW participants highlights the role for intersectional considerations in future research. |
| first_indexed | 2024-04-24T12:40:23Z |
| format | Article |
| id | doaj.art-500412b4547a438fac64a31487f8d9b1 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T12:40:23Z |
| publishDate | 2024-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-500412b4547a438fac64a31487f8d9b12024-04-07T11:16:30ZengNature PortfolioScientific Reports2045-23222024-04-0114111010.1038/s41598-024-58120-9Environmental and sociocultural factors are associated with pain-related brain structure among diverse individuals with chronic musculoskeletal pain: intersectional considerationsLisa H. Domenico0Jared J. Tanner1Angela M. Mickle2Ellen L. Terry3Cynthia Garvan4Song Lai5Hrishikesh Deshpande6Roland Staud7David Redden8Catherine C. Price9Burel R. Goodin10Roger B. Fillingim11Kimberly T. Sibille12Department of Biobehavioral Nursing Science, College of Nursing, University of FloridaDepartment of Clinical and Health Psychology, University of FloridaPain Research and Intervention Center of Excellence, University of FloridaDepartment of Biobehavioral Nursing Science, College of Nursing, University of FloridaDepartment of Anesthesiology, Division of Pain Medicine, University of FloridaDepartment of Radiation Oncology, University of FloridaDepartment of Radiology, University of Alabama at BirminghamDepartment of Rheumatology, College of Medicine, University of FloridaDepartment of Biostatistics, University of Alabama at BirminghamDepartment of Clinical and Health Psychology, University of FloridaDepartment of Psychology, University of Alabama at BirminghamDepartment of Community Dentistry and Behavioral Science, University of Florida College of DentistryDepartment of Physical Medicine and Rehabilitation, University of FloridaAbstract Chronic musculoskeletal pain including knee osteoarthritis (OA) is a leading cause of disability worldwide. Previous research indicates ethnic-race groups differ in the pain and functional limitations experienced with knee OA. However, when socioenvironmental factors are included in analyses, group differences in pain and function wane. Pain-related brain structures are another area where ethnic-race group differences have been observed. Environmental and sociocultural factors e.g., income, education, experiences of discrimination, and social support influence brain structures. We investigate if environmental and sociocultural factors reduce previously observed ethnic-race group differences in pain-related brain structures. Data were analyzed from 147 self-identified non-Hispanic black (NHB) and non-Hispanic white (NHW), middle and older aged adults with knee pain in the past month. Information collected included health and pain history, environmental and sociocultural resources, and brain imaging. The NHB adults were younger and reported lower income and education compared to their NHW peers. In hierarchical multiple regression models, sociocultural and environmental factors explained 6–37% of the variance in pain-related brain regions. Self-identified ethnicity-race provided an additional 4–13% of explanatory value in the amygdala, hippocampus, insula, bilateral primary somatosensory cortex, and thalamus. In the rostral/caudal anterior cingulate and dorsolateral prefrontal cortex, self-identified ethnicity-race was not a predictor after accounting for environmental, sociocultural, and demographic factors. Findings help to disentangle and identify some of the factors contributing to ethnic-race group disparities in pain-related brain structures. Numerous arrays of environmental and sociocultural factors remain to be investigated. Further, the differing sociodemographic representation of our NHB and NHW participants highlights the role for intersectional considerations in future research.https://doi.org/10.1038/s41598-024-58120-9EnvironmentalSocioculturalEthnicity-raceMusculoskeletal painNeuroimaging |
| spellingShingle | Lisa H. Domenico Jared J. Tanner Angela M. Mickle Ellen L. Terry Cynthia Garvan Song Lai Hrishikesh Deshpande Roland Staud David Redden Catherine C. Price Burel R. Goodin Roger B. Fillingim Kimberly T. Sibille Environmental and sociocultural factors are associated with pain-related brain structure among diverse individuals with chronic musculoskeletal pain: intersectional considerations Scientific Reports Environmental Sociocultural Ethnicity-race Musculoskeletal pain Neuroimaging |
| title | Environmental and sociocultural factors are associated with pain-related brain structure among diverse individuals with chronic musculoskeletal pain: intersectional considerations |
| title_full | Environmental and sociocultural factors are associated with pain-related brain structure among diverse individuals with chronic musculoskeletal pain: intersectional considerations |
| title_fullStr | Environmental and sociocultural factors are associated with pain-related brain structure among diverse individuals with chronic musculoskeletal pain: intersectional considerations |
| title_full_unstemmed | Environmental and sociocultural factors are associated with pain-related brain structure among diverse individuals with chronic musculoskeletal pain: intersectional considerations |
| title_short | Environmental and sociocultural factors are associated with pain-related brain structure among diverse individuals with chronic musculoskeletal pain: intersectional considerations |
| title_sort | environmental and sociocultural factors are associated with pain related brain structure among diverse individuals with chronic musculoskeletal pain intersectional considerations |
| topic | Environmental Sociocultural Ethnicity-race Musculoskeletal pain Neuroimaging |
| url | https://doi.org/10.1038/s41598-024-58120-9 |
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