Gut-Brain Axis in the Early Postnatal Years of Life: A Developmental Perspective
Emerging evidence suggests that alterations in the development of the gastrointestinal (GI) tract during the early postnatal period can influence brain development and vice-versa. It is increasingly recognized that communication between the GI tract and brain is mainly driven by neural, endocrine, i...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Integrative Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnint.2020.00044/full |
| _version_ | 1818294530442526720 |
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| author | Ankita Jena Ankita Jena Ankita Jena Carlos A. Montoya Carlos A. Montoya Jane A. Mullaney Jane A. Mullaney Jane A. Mullaney Ryan N. Dilger Wayne Young Wayne Young Wayne Young Warren C. McNabb Warren C. McNabb Nicole C. Roy Nicole C. Roy Nicole C. Roy Nicole C. Roy |
| author_facet | Ankita Jena Ankita Jena Ankita Jena Carlos A. Montoya Carlos A. Montoya Jane A. Mullaney Jane A. Mullaney Jane A. Mullaney Ryan N. Dilger Wayne Young Wayne Young Wayne Young Warren C. McNabb Warren C. McNabb Nicole C. Roy Nicole C. Roy Nicole C. Roy Nicole C. Roy |
| author_sort | Ankita Jena |
| collection | DOAJ |
| description | Emerging evidence suggests that alterations in the development of the gastrointestinal (GI) tract during the early postnatal period can influence brain development and vice-versa. It is increasingly recognized that communication between the GI tract and brain is mainly driven by neural, endocrine, immune, and metabolic mediators, collectively called the gut-brain axis (GBA). Changes in the GBA mediators occur in response to the developmental changes in the body during this period. This review provides an overview of major developmental events in the GI tract and brain in the early postnatal period and their parallel developmental trajectories under physiological conditions. Current knowledge of GBA mediators in context to brain function and behavioral outcomes and their synthesis and metabolism (site, timing, etc.) is discussed. This review also presents hypotheses on the role of the GBA mediators in response to the parallel development of the GI tract and brain in infants. |
| first_indexed | 2024-12-13T03:33:13Z |
| format | Article |
| id | doaj.art-5006ee084e56465f974b34d3b78f1070 |
| institution | Directory Open Access Journal |
| issn | 1662-5145 |
| language | English |
| last_indexed | 2024-12-13T03:33:13Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Integrative Neuroscience |
| spelling | doaj.art-5006ee084e56465f974b34d3b78f10702022-12-22T00:01:06ZengFrontiers Media S.A.Frontiers in Integrative Neuroscience1662-51452020-08-011410.3389/fnint.2020.00044542226Gut-Brain Axis in the Early Postnatal Years of Life: A Developmental PerspectiveAnkita Jena0Ankita Jena1Ankita Jena2Carlos A. Montoya3Carlos A. Montoya4Jane A. Mullaney5Jane A. Mullaney6Jane A. Mullaney7Ryan N. Dilger8Wayne Young9Wayne Young10Wayne Young11Warren C. McNabb12Warren C. McNabb13Nicole C. Roy14Nicole C. Roy15Nicole C. Roy16Nicole C. Roy17School of Food & Advanced Technology, College of Sciences, Massey University, Palmerston North, New ZealandThe Riddet Institute, Massey University, Palmerston North, New ZealandFood Nutrition & Health, Grasslands Research Centre, AgResearch, Palmerston North, New ZealandThe Riddet Institute, Massey University, Palmerston North, New ZealandFood Nutrition & Health, Grasslands Research Centre, AgResearch, Palmerston North, New ZealandThe Riddet Institute, Massey University, Palmerston North, New ZealandFood Nutrition & Health, Grasslands Research Centre, AgResearch, Palmerston North, New ZealandHigh-Value Nutrition National Science Challenge, Auckland, New ZealandDepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, United StatesThe Riddet Institute, Massey University, Palmerston North, New ZealandFood Nutrition & Health, Grasslands Research Centre, AgResearch, Palmerston North, New ZealandHigh-Value Nutrition National Science Challenge, Auckland, New ZealandThe Riddet Institute, Massey University, Palmerston North, New ZealandHigh-Value Nutrition National Science Challenge, Auckland, New ZealandThe Riddet Institute, Massey University, Palmerston North, New ZealandHigh-Value Nutrition National Science Challenge, Auckland, New ZealandLiggins Institute, The University of Auckland, Auckland, New ZealandDepartment of Human Nutrition, University of Otago, Dunedin, New ZealandEmerging evidence suggests that alterations in the development of the gastrointestinal (GI) tract during the early postnatal period can influence brain development and vice-versa. It is increasingly recognized that communication between the GI tract and brain is mainly driven by neural, endocrine, immune, and metabolic mediators, collectively called the gut-brain axis (GBA). Changes in the GBA mediators occur in response to the developmental changes in the body during this period. This review provides an overview of major developmental events in the GI tract and brain in the early postnatal period and their parallel developmental trajectories under physiological conditions. Current knowledge of GBA mediators in context to brain function and behavioral outcomes and their synthesis and metabolism (site, timing, etc.) is discussed. This review also presents hypotheses on the role of the GBA mediators in response to the parallel development of the GI tract and brain in infants.https://www.frontiersin.org/article/10.3389/fnint.2020.00044/fullgut-brain axisbraingastrointestinal tractpostnatal developmentcognitionmetabolites |
| spellingShingle | Ankita Jena Ankita Jena Ankita Jena Carlos A. Montoya Carlos A. Montoya Jane A. Mullaney Jane A. Mullaney Jane A. Mullaney Ryan N. Dilger Wayne Young Wayne Young Wayne Young Warren C. McNabb Warren C. McNabb Nicole C. Roy Nicole C. Roy Nicole C. Roy Nicole C. Roy Gut-Brain Axis in the Early Postnatal Years of Life: A Developmental Perspective Frontiers in Integrative Neuroscience gut-brain axis brain gastrointestinal tract postnatal development cognition metabolites |
| title | Gut-Brain Axis in the Early Postnatal Years of Life: A Developmental Perspective |
| title_full | Gut-Brain Axis in the Early Postnatal Years of Life: A Developmental Perspective |
| title_fullStr | Gut-Brain Axis in the Early Postnatal Years of Life: A Developmental Perspective |
| title_full_unstemmed | Gut-Brain Axis in the Early Postnatal Years of Life: A Developmental Perspective |
| title_short | Gut-Brain Axis in the Early Postnatal Years of Life: A Developmental Perspective |
| title_sort | gut brain axis in the early postnatal years of life a developmental perspective |
| topic | gut-brain axis brain gastrointestinal tract postnatal development cognition metabolites |
| url | https://www.frontiersin.org/article/10.3389/fnint.2020.00044/full |
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