Modulation of osteogenic differentiation by Escherichia coli-derived recombinant bone morphogenetic protein-2

Modulation of osteogenic differentiation by Escherichia coli-derived recombinant bone morphogenetic protein-2

Abstract Recombinant human bone morphogenetic protein-2 (rhBMP-2), a key regulator of osteogenesis, induces the differentiation of mesenchymal cells into cartilage or bone tissues. Early orthopedic and dental studies often used mammalian cell-derived rhBMP-2, especially Chinese hamster ovary (CHO) c...

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Bibliographic Details
Main Authors:	Nam-Hyun Kim, Seon-Kyong Jung, Juno Lee, Pahn-Shick Chang, Seung-Hoon Kang
Format:	Article
Language:	English
Published:	SpringerOpen 2022-08-01
Series:	AMB Express
Subjects:	rhBMP-2 Osteogenesis BMP receptor Smad-signaling pathway qRT-PCR ALP assay
Online Access:	https://doi.org/10.1186/s13568-022-01443-5

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