The relationship between cancer associated fibroblasts biomarkers and prognosis of breast cancer: a systematic review and meta-analysis
Background To elucidate the relationship between cancer-associated fibroblast (CAFs) biomarkers and the prognosis of breast cancer patients for individualized CAFs-targeting treatment. Methodology PubMed, Web of Science, Cochrane, and Embase databases were searched for CAFs-related studies of breast...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PeerJ Inc.
2024-02-01
|
| Series: | PeerJ |
| Subjects: | |
| Online Access: | https://peerj.com/articles/16958.pdf |
| _version_ | 1797295339690000384 |
|---|---|
| author | Meimei Cui Hao Dong Wanli Duan Xuejie Wang Yongping Liu Lihong Shi Baogang Zhang |
| author_facet | Meimei Cui Hao Dong Wanli Duan Xuejie Wang Yongping Liu Lihong Shi Baogang Zhang |
| author_sort | Meimei Cui |
| collection | DOAJ |
| description | Background To elucidate the relationship between cancer-associated fibroblast (CAFs) biomarkers and the prognosis of breast cancer patients for individualized CAFs-targeting treatment. Methodology PubMed, Web of Science, Cochrane, and Embase databases were searched for CAFs-related studies of breast cancer patients from their inception to September, 2023. Meta-analysis was performed using R 4.2.2 software. Sensitivity analyses were performed to explore the sources of heterogeneity. Funnel plot and Egger’s test were used to assess the publication bias. Results Twenty-seven studies including 6,830 patients were selected. Univariate analysis showed that high expression of platelet-derived growth factor receptor-β (PDGFR-β) (P = 0.0055), tissue inhibitor of metalloproteinase-2 (TIMP-2) (P < 0.0001), matrix metalloproteinase (MMP) 9 (P < 0.0001), MMP 11 (P < 0.0001) and MMP 13 (P = 0.0009) in CAFs were correlated with reduced recurrence-free survival (RFS)/disease-free survival (DFS)/metastasis-free survival (MFS)/event-free survival (EFS) respectively. Multivariate analysis showed that high expression of α-smooth muscle actin (α-SMA) (P = 0.0002), podoplanin (PDPN) (P = 0.0008), and PDGFR-β (P = 0.0470) in CAFs was associated with reduced RFS/DFS/MFS/EFS respectively. Furthermore, PDPN and PDGFR-β expression in CAFs of poorly differentiated breast cancer patients were higher than that of patients with relatively better differentiated breast cancer. In addition, there is a positive correlation between the expression of PDPN and human epidermal growth factor receptor-2 (HER-2). Conclusions The high expression of α-SMA, PDPN, PDGFR-β in CAFs leads to worse clinical outcomes in breast cancer, indicating their roles as prognostic biomarkers and potential therapeutic targets. |
| first_indexed | 2024-03-07T21:46:15Z |
| format | Article |
| id | doaj.art-500813f580e54290b011d4ce213b2ec7 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-07T21:46:15Z |
| publishDate | 2024-02-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-500813f580e54290b011d4ce213b2ec72024-02-25T15:05:19ZengPeerJ Inc.PeerJ2167-83592024-02-0112e1695810.7717/peerj.16958The relationship between cancer associated fibroblasts biomarkers and prognosis of breast cancer: a systematic review and meta-analysisMeimei Cui0Hao Dong1Wanli Duan2Xuejie Wang3Yongping Liu4Lihong Shi5Baogang Zhang6Department of Pathology, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, Shandong, ChinaDepartment of Pathology, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, Shandong, ChinaDepartment of Pathology, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, Shandong, ChinaDepartment of Pathology, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, Shandong, ChinaDepartment of Pathology, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, Shandong, ChinaSchool of Rehabilitation Medicine, Shandong Second Medical University, Weifang, Shandong, ChinaDepartment of Pathology, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, Shandong, ChinaBackground To elucidate the relationship between cancer-associated fibroblast (CAFs) biomarkers and the prognosis of breast cancer patients for individualized CAFs-targeting treatment. Methodology PubMed, Web of Science, Cochrane, and Embase databases were searched for CAFs-related studies of breast cancer patients from their inception to September, 2023. Meta-analysis was performed using R 4.2.2 software. Sensitivity analyses were performed to explore the sources of heterogeneity. Funnel plot and Egger’s test were used to assess the publication bias. Results Twenty-seven studies including 6,830 patients were selected. Univariate analysis showed that high expression of platelet-derived growth factor receptor-β (PDGFR-β) (P = 0.0055), tissue inhibitor of metalloproteinase-2 (TIMP-2) (P < 0.0001), matrix metalloproteinase (MMP) 9 (P < 0.0001), MMP 11 (P < 0.0001) and MMP 13 (P = 0.0009) in CAFs were correlated with reduced recurrence-free survival (RFS)/disease-free survival (DFS)/metastasis-free survival (MFS)/event-free survival (EFS) respectively. Multivariate analysis showed that high expression of α-smooth muscle actin (α-SMA) (P = 0.0002), podoplanin (PDPN) (P = 0.0008), and PDGFR-β (P = 0.0470) in CAFs was associated with reduced RFS/DFS/MFS/EFS respectively. Furthermore, PDPN and PDGFR-β expression in CAFs of poorly differentiated breast cancer patients were higher than that of patients with relatively better differentiated breast cancer. In addition, there is a positive correlation between the expression of PDPN and human epidermal growth factor receptor-2 (HER-2). Conclusions The high expression of α-SMA, PDPN, PDGFR-β in CAFs leads to worse clinical outcomes in breast cancer, indicating their roles as prognostic biomarkers and potential therapeutic targets.https://peerj.com/articles/16958.pdfBreast cancerCancer associated fibroblastsMeta-analysisPrognostic biomarkers |
| spellingShingle | Meimei Cui Hao Dong Wanli Duan Xuejie Wang Yongping Liu Lihong Shi Baogang Zhang The relationship between cancer associated fibroblasts biomarkers and prognosis of breast cancer: a systematic review and meta-analysis PeerJ Breast cancer Cancer associated fibroblasts Meta-analysis Prognostic biomarkers |
| title | The relationship between cancer associated fibroblasts biomarkers and prognosis of breast cancer: a systematic review and meta-analysis |
| title_full | The relationship between cancer associated fibroblasts biomarkers and prognosis of breast cancer: a systematic review and meta-analysis |
| title_fullStr | The relationship between cancer associated fibroblasts biomarkers and prognosis of breast cancer: a systematic review and meta-analysis |
| title_full_unstemmed | The relationship between cancer associated fibroblasts biomarkers and prognosis of breast cancer: a systematic review and meta-analysis |
| title_short | The relationship between cancer associated fibroblasts biomarkers and prognosis of breast cancer: a systematic review and meta-analysis |
| title_sort | relationship between cancer associated fibroblasts biomarkers and prognosis of breast cancer a systematic review and meta analysis |
| topic | Breast cancer Cancer associated fibroblasts Meta-analysis Prognostic biomarkers |
| url | https://peerj.com/articles/16958.pdf |
| work_keys_str_mv | AT meimeicui therelationshipbetweencancerassociatedfibroblastsbiomarkersandprognosisofbreastcancerasystematicreviewandmetaanalysis AT haodong therelationshipbetweencancerassociatedfibroblastsbiomarkersandprognosisofbreastcancerasystematicreviewandmetaanalysis AT wanliduan therelationshipbetweencancerassociatedfibroblastsbiomarkersandprognosisofbreastcancerasystematicreviewandmetaanalysis AT xuejiewang therelationshipbetweencancerassociatedfibroblastsbiomarkersandprognosisofbreastcancerasystematicreviewandmetaanalysis AT yongpingliu therelationshipbetweencancerassociatedfibroblastsbiomarkersandprognosisofbreastcancerasystematicreviewandmetaanalysis AT lihongshi therelationshipbetweencancerassociatedfibroblastsbiomarkersandprognosisofbreastcancerasystematicreviewandmetaanalysis AT baogangzhang therelationshipbetweencancerassociatedfibroblastsbiomarkersandprognosisofbreastcancerasystematicreviewandmetaanalysis AT meimeicui relationshipbetweencancerassociatedfibroblastsbiomarkersandprognosisofbreastcancerasystematicreviewandmetaanalysis AT haodong relationshipbetweencancerassociatedfibroblastsbiomarkersandprognosisofbreastcancerasystematicreviewandmetaanalysis AT wanliduan relationshipbetweencancerassociatedfibroblastsbiomarkersandprognosisofbreastcancerasystematicreviewandmetaanalysis AT xuejiewang relationshipbetweencancerassociatedfibroblastsbiomarkersandprognosisofbreastcancerasystematicreviewandmetaanalysis AT yongpingliu relationshipbetweencancerassociatedfibroblastsbiomarkersandprognosisofbreastcancerasystematicreviewandmetaanalysis AT lihongshi relationshipbetweencancerassociatedfibroblastsbiomarkersandprognosisofbreastcancerasystematicreviewandmetaanalysis AT baogangzhang relationshipbetweencancerassociatedfibroblastsbiomarkersandprognosisofbreastcancerasystematicreviewandmetaanalysis |