Modulation of the Tumor Microenvironment with Trastuzumab Enables Radiosensitization in HER2+ Breast Cancer

Modulation of the Tumor Microenvironment with Trastuzumab Enables Radiosensitization in HER2+ Breast Cancer

DNA damage repair and tumor hypoxia contribute to intratumoral cellular and molecular heterogeneity and affect radiation response. The goal of this study is to investigate anti-HER2-induced radiosensitization of the tumor microenvironment to enhance fractionated radiotherapy in models of HER2+ breas...

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Bibliographic Details
Main Authors:	Patrick N. Song, Ameer Mansur, Yun Lu, Deborah Della Manna, Andrew Burns, Sharon Samuel, Katherine Heinzman, Suzanne E. Lapi, Eddy S. Yang, Anna G. Sorace
Format:	Article
Language:	English
Published:	MDPI AG 2022-02-01
Series:	Cancers
Subjects:	PDX BT474 MDA-MB-361 BCM 3472 trastuzumab [<sup>18</sup>F]-FMISO
Online Access:	https://www.mdpi.com/2072-6694/14/4/1015

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