Traditional Herbal Medicine-Derived Sulforaphene LFS-01 Reverses Colitis in Mice by Selectively Altering the Gut Microbiota and Promoting Intestinal Gamma-Delta T Cells

Traditional Herbal Medicine-Derived Sulforaphene LFS-01 Reverses Colitis in Mice by Selectively Altering the Gut Microbiota and Promoting Intestinal Gamma-Delta T Cells

Sulforaphene (LFS-01) is a natural compound derived from traditional herbal medicine. Here, we show that oral administration of LFS-01 is able to dramatically alter the skewed gut microbiota and reverse colitis in model mice associated with an increase of intestinal γδT cells. Through 16S rDNA seque...

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Bibliographic Details
Main Authors: Ming Li, Jiali Gao, Yan Tang, Meishuo Liu, Sijin Wu, Kunli Qu, Xiangyu Long, Huajun Li, Min Liu, Yinhui Liu, Jieli Yuan, Lei Mao, Yu Liu, Xiliang Zheng, Erkang Wang, Jin Wang, Yongliang Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Pharmacology
Subjects:
colitis
microbiota
sulforaphene
γδT cells
barrier function
herbal medicine
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00959/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00959/full

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