Biological mechanisms and clinical significance of endoplasmic reticulum oxidoreductase 1 alpha (ERO1α) in human cancer
Abstract A firm link between endoplasmic reticulum (ER) stress and tumors has been wildly reported. Endoplasmic reticulum oxidoreductase 1 alpha (ERO1α), an ER-resident thiol oxidoreductase, is confirmed to be highly upregulated in various cancer types and associated with a significantly worse progn...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13046-024-02990-4 |
| _version_ | 1797266560554893312 |
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| author | Peng Chen Amit Sharma Hans Weiher Ingo G.H. Schmidt-Wolf |
| author_facet | Peng Chen Amit Sharma Hans Weiher Ingo G.H. Schmidt-Wolf |
| author_sort | Peng Chen |
| collection | DOAJ |
| description | Abstract A firm link between endoplasmic reticulum (ER) stress and tumors has been wildly reported. Endoplasmic reticulum oxidoreductase 1 alpha (ERO1α), an ER-resident thiol oxidoreductase, is confirmed to be highly upregulated in various cancer types and associated with a significantly worse prognosis. Of importance, under ER stress, the functional interplay of ERO1α/PDI axis plays a pivotal role to orchestrate proper protein folding and other key processes. Multiple lines of evidence propose ERO1α as an attractive potential target for cancer treatment. However, the unavailability of specific inhibitor for ERO1α, its molecular inter-relatedness with closely related paralog ERO1β and the tightly regulated processes with other members of flavoenzyme family of enzymes, raises several concerns about its clinical translation. Herein, we have provided a detailed description of ERO1α in human cancers and its vulnerability towards the aforementioned concerns. Besides, we have discussed a few key considerations that may improve our understanding about ERO1α in tumors. |
| first_indexed | 2024-04-25T01:02:38Z |
| format | Article |
| id | doaj.art-500a17bba7f641ce9780392d3808f1fd |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-04-25T01:02:38Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-500a17bba7f641ce9780392d3808f1fd2024-03-10T12:24:25ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662024-03-0143111810.1186/s13046-024-02990-4Biological mechanisms and clinical significance of endoplasmic reticulum oxidoreductase 1 alpha (ERO1α) in human cancerPeng Chen0Amit Sharma1Hans Weiher2Ingo G.H. Schmidt-Wolf3Department of Integrated Oncology, Center for Integrated Oncology (CIO), University Hospital BonnDepartment of Integrated Oncology, Center for Integrated Oncology (CIO), University Hospital BonnDepartment of Applied Natural Sciences, Bonn-Rhein-Sieg University of Applied SciencesDepartment of Integrated Oncology, Center for Integrated Oncology (CIO), University Hospital BonnAbstract A firm link between endoplasmic reticulum (ER) stress and tumors has been wildly reported. Endoplasmic reticulum oxidoreductase 1 alpha (ERO1α), an ER-resident thiol oxidoreductase, is confirmed to be highly upregulated in various cancer types and associated with a significantly worse prognosis. Of importance, under ER stress, the functional interplay of ERO1α/PDI axis plays a pivotal role to orchestrate proper protein folding and other key processes. Multiple lines of evidence propose ERO1α as an attractive potential target for cancer treatment. However, the unavailability of specific inhibitor for ERO1α, its molecular inter-relatedness with closely related paralog ERO1β and the tightly regulated processes with other members of flavoenzyme family of enzymes, raises several concerns about its clinical translation. Herein, we have provided a detailed description of ERO1α in human cancers and its vulnerability towards the aforementioned concerns. Besides, we have discussed a few key considerations that may improve our understanding about ERO1α in tumors.https://doi.org/10.1186/s13046-024-02990-4CancerER stressERO1αPDIImmune escapePrognosis |
| spellingShingle | Peng Chen Amit Sharma Hans Weiher Ingo G.H. Schmidt-Wolf Biological mechanisms and clinical significance of endoplasmic reticulum oxidoreductase 1 alpha (ERO1α) in human cancer Journal of Experimental & Clinical Cancer Research Cancer ER stress ERO1α PDI Immune escape Prognosis |
| title | Biological mechanisms and clinical significance of endoplasmic reticulum oxidoreductase 1 alpha (ERO1α) in human cancer |
| title_full | Biological mechanisms and clinical significance of endoplasmic reticulum oxidoreductase 1 alpha (ERO1α) in human cancer |
| title_fullStr | Biological mechanisms and clinical significance of endoplasmic reticulum oxidoreductase 1 alpha (ERO1α) in human cancer |
| title_full_unstemmed | Biological mechanisms and clinical significance of endoplasmic reticulum oxidoreductase 1 alpha (ERO1α) in human cancer |
| title_short | Biological mechanisms and clinical significance of endoplasmic reticulum oxidoreductase 1 alpha (ERO1α) in human cancer |
| title_sort | biological mechanisms and clinical significance of endoplasmic reticulum oxidoreductase 1 alpha ero1α in human cancer |
| topic | Cancer ER stress ERO1α PDI Immune escape Prognosis |
| url | https://doi.org/10.1186/s13046-024-02990-4 |
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