Fc-Dependent Immunomodulation Induced by Antiviral Therapeutic Antibodies: New Perspectives for Eliciting Protective Immune Responses
The multiple mechanisms of action of antiviral monoclonal antibodies (mAbs) have made these molecules a potential therapeutic alternative for treating severe viral infections. In addition to their direct effect on viral propagation, several studies have shown that mAbs are able to enhance the host’s...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Antibodies |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4468/11/3/50 |
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| author | Mireia Pelegrin Soledad Marsile-Medun Daouda Abba-Moussa Manon Souchard Mar Naranjo-Gomez |
| author_facet | Mireia Pelegrin Soledad Marsile-Medun Daouda Abba-Moussa Manon Souchard Mar Naranjo-Gomez |
| author_sort | Mireia Pelegrin |
| collection | DOAJ |
| description | The multiple mechanisms of action of antiviral monoclonal antibodies (mAbs) have made these molecules a potential therapeutic alternative for treating severe viral infections. In addition to their direct effect on viral propagation, several studies have shown that mAbs are able to enhance the host’s adaptive immune response and generate long-lasting protective immunity. Such immunomodulatory effects occur in an Fc-dependent manner and rely on Fc-FcγR interactions. It is noteworthy that several FcγR-expressing cells have been shown to play a key role in enhancing humoral and cellular immune responses (so-called “vaccinal effects”) in different experimental settings. This review recalls recent findings concerning the vaccinal effects induced by antiviral mAbs, both in several preclinical animal models and in patients treated with mAbs. It summarizes the main cellular and molecular mechanisms involved in these immunomodulatory properties of antiviral mAbs identified in different pathological contexts. It also describes potential therapeutic interventions to enhance host immune responses that could guide the design of improved mAb-based immunotherapies. |
| first_indexed | 2024-03-10T00:53:42Z |
| format | Article |
| id | doaj.art-500c0716a20f4e8ca80c7d02f98b17b9 |
| institution | Directory Open Access Journal |
| issn | 2073-4468 |
| language | English |
| last_indexed | 2024-03-10T00:53:42Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibodies |
| spelling | doaj.art-500c0716a20f4e8ca80c7d02f98b17b92023-11-23T14:46:09ZengMDPI AGAntibodies2073-44682022-07-011135010.3390/antib11030050Fc-Dependent Immunomodulation Induced by Antiviral Therapeutic Antibodies: New Perspectives for Eliciting Protective Immune ResponsesMireia Pelegrin0Soledad Marsile-Medun1Daouda Abba-Moussa2Manon Souchard3Mar Naranjo-Gomez4IRMB, Univ Montpellier, INSERM, CNRS, 34000 Montpellier, FranceIRMB, Univ Montpellier, INSERM, CNRS, 34000 Montpellier, FranceIRMB, Univ Montpellier, INSERM, CNRS, 34000 Montpellier, FranceIRMB, Univ Montpellier, INSERM, CNRS, 34000 Montpellier, FranceIRMB, Univ Montpellier, INSERM, CNRS, 34000 Montpellier, FranceThe multiple mechanisms of action of antiviral monoclonal antibodies (mAbs) have made these molecules a potential therapeutic alternative for treating severe viral infections. In addition to their direct effect on viral propagation, several studies have shown that mAbs are able to enhance the host’s adaptive immune response and generate long-lasting protective immunity. Such immunomodulatory effects occur in an Fc-dependent manner and rely on Fc-FcγR interactions. It is noteworthy that several FcγR-expressing cells have been shown to play a key role in enhancing humoral and cellular immune responses (so-called “vaccinal effects”) in different experimental settings. This review recalls recent findings concerning the vaccinal effects induced by antiviral mAbs, both in several preclinical animal models and in patients treated with mAbs. It summarizes the main cellular and molecular mechanisms involved in these immunomodulatory properties of antiviral mAbs identified in different pathological contexts. It also describes potential therapeutic interventions to enhance host immune responses that could guide the design of improved mAb-based immunotherapies.https://www.mdpi.com/2073-4468/11/3/50antiviral immunityantiviral monoclonal antibodiesimmunotherapyFcγRvaccinal effectimmunomodulation |
| spellingShingle | Mireia Pelegrin Soledad Marsile-Medun Daouda Abba-Moussa Manon Souchard Mar Naranjo-Gomez Fc-Dependent Immunomodulation Induced by Antiviral Therapeutic Antibodies: New Perspectives for Eliciting Protective Immune Responses Antibodies antiviral immunity antiviral monoclonal antibodies immunotherapy FcγR vaccinal effect immunomodulation |
| title | Fc-Dependent Immunomodulation Induced by Antiviral Therapeutic Antibodies: New Perspectives for Eliciting Protective Immune Responses |
| title_full | Fc-Dependent Immunomodulation Induced by Antiviral Therapeutic Antibodies: New Perspectives for Eliciting Protective Immune Responses |
| title_fullStr | Fc-Dependent Immunomodulation Induced by Antiviral Therapeutic Antibodies: New Perspectives for Eliciting Protective Immune Responses |
| title_full_unstemmed | Fc-Dependent Immunomodulation Induced by Antiviral Therapeutic Antibodies: New Perspectives for Eliciting Protective Immune Responses |
| title_short | Fc-Dependent Immunomodulation Induced by Antiviral Therapeutic Antibodies: New Perspectives for Eliciting Protective Immune Responses |
| title_sort | fc dependent immunomodulation induced by antiviral therapeutic antibodies new perspectives for eliciting protective immune responses |
| topic | antiviral immunity antiviral monoclonal antibodies immunotherapy FcγR vaccinal effect immunomodulation |
| url | https://www.mdpi.com/2073-4468/11/3/50 |
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