Umbilical Cord-Derived Wharton’s Jelly for Regenerative Medicine Applications: A Systematic Review
Musculoskeletal ailments affect millions of people around the world and place a high burden on healthcare. Traditional treatment modalities are limited and do not address underlying pathologies. Mesenchymal stem cells (MSCs) have emerged as an exciting therapeutic alternative and Wharton’s jelly-der...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/11/1090 |
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| author | Benjamin J. Main Nicola Maffulli Josiah A. Valk Hugo C. Rodriguez Manu Gupta Saadiq F. El-Amin Ashim Gupta |
| author_facet | Benjamin J. Main Nicola Maffulli Josiah A. Valk Hugo C. Rodriguez Manu Gupta Saadiq F. El-Amin Ashim Gupta |
| author_sort | Benjamin J. Main |
| collection | DOAJ |
| description | Musculoskeletal ailments affect millions of people around the world and place a high burden on healthcare. Traditional treatment modalities are limited and do not address underlying pathologies. Mesenchymal stem cells (MSCs) have emerged as an exciting therapeutic alternative and Wharton’s jelly-derived mesenchymal stem cells (WJSCs) are some of these. This review reports the clinical and functional outcomes of the applications of WJSCs in orthopedic surgery. A systematic review was conducted utilizing the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. The studies that used culture-expanded, mesenchymal stem or stromal cells, MSCs and/or connective tissues procured from Wharton’s jelly (WJ), from January 2010 to October 2021, were included. Conventional non-operative therapies and placebos were used as comparisons. Six studies that directly discussed WJSCs use in an animal model or the basic scientific testing using an injury model were identified. Five publications studied cartilage injury, three studied degenerative disc disease, one was related to osteoarthritis, and one was related to osteochondral defects. The results of these studies suggested the benefits of WJSCs in the management of these orthopedic pathologies. To adequately assess the safety and efficacy of WJSCs in orthopedic surgery, further randomized controlled clinical studies are necessary. |
| first_indexed | 2024-03-10T05:09:52Z |
| format | Article |
| id | doaj.art-500dd8f8a81843b3af7c6294072e71dd |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T05:09:52Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-500dd8f8a81843b3af7c6294072e71dd2023-11-23T00:55:05ZengMDPI AGPharmaceuticals1424-82472021-10-011411109010.3390/ph14111090Umbilical Cord-Derived Wharton’s Jelly for Regenerative Medicine Applications: A Systematic ReviewBenjamin J. Main0Nicola Maffulli1Josiah A. Valk2Hugo C. Rodriguez3Manu Gupta4Saadiq F. El-Amin5Ashim Gupta6Department of Orthopaedic Surgery, Beaumont Hospital Farmington Hills, Farmington Hills, MI 48336, USADepartment of Musculoskeletal Disorders, School of Medicine and Surgery, University of Salerno, 84081 Baronissi, ItalyDepartment of Orthopaedic Surgery, Beaumont Hospital Farmington Hills, Farmington Hills, MI 48336, USAHolly Cross Orthopedic Institute, Fort Lauderdale, FL 33334, USAPolar Aesthetics Dental & Cosmetic Centre, Noida 201301, Uttar Pradesh, IndiaEl-Amin Orthopaedic and Sports Medicine Institute, Lawrenceville, GA 30043, USABioIntegrate, Lawrenceville, GA 30043, USAMusculoskeletal ailments affect millions of people around the world and place a high burden on healthcare. Traditional treatment modalities are limited and do not address underlying pathologies. Mesenchymal stem cells (MSCs) have emerged as an exciting therapeutic alternative and Wharton’s jelly-derived mesenchymal stem cells (WJSCs) are some of these. This review reports the clinical and functional outcomes of the applications of WJSCs in orthopedic surgery. A systematic review was conducted utilizing the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. The studies that used culture-expanded, mesenchymal stem or stromal cells, MSCs and/or connective tissues procured from Wharton’s jelly (WJ), from January 2010 to October 2021, were included. Conventional non-operative therapies and placebos were used as comparisons. Six studies that directly discussed WJSCs use in an animal model or the basic scientific testing using an injury model were identified. Five publications studied cartilage injury, three studied degenerative disc disease, one was related to osteoarthritis, and one was related to osteochondral defects. The results of these studies suggested the benefits of WJSCs in the management of these orthopedic pathologies. To adequately assess the safety and efficacy of WJSCs in orthopedic surgery, further randomized controlled clinical studies are necessary.https://www.mdpi.com/1424-8247/14/11/1090umbilical cordWharton’s jellyregenerative medicinemesenchymal stem cellsmesenchymal stromal cellsWharton’s jelly mesenchymal stem cells |
| spellingShingle | Benjamin J. Main Nicola Maffulli Josiah A. Valk Hugo C. Rodriguez Manu Gupta Saadiq F. El-Amin Ashim Gupta Umbilical Cord-Derived Wharton’s Jelly for Regenerative Medicine Applications: A Systematic Review Pharmaceuticals umbilical cord Wharton’s jelly regenerative medicine mesenchymal stem cells mesenchymal stromal cells Wharton’s jelly mesenchymal stem cells |
| title | Umbilical Cord-Derived Wharton’s Jelly for Regenerative Medicine Applications: A Systematic Review |
| title_full | Umbilical Cord-Derived Wharton’s Jelly for Regenerative Medicine Applications: A Systematic Review |
| title_fullStr | Umbilical Cord-Derived Wharton’s Jelly for Regenerative Medicine Applications: A Systematic Review |
| title_full_unstemmed | Umbilical Cord-Derived Wharton’s Jelly for Regenerative Medicine Applications: A Systematic Review |
| title_short | Umbilical Cord-Derived Wharton’s Jelly for Regenerative Medicine Applications: A Systematic Review |
| title_sort | umbilical cord derived wharton s jelly for regenerative medicine applications a systematic review |
| topic | umbilical cord Wharton’s jelly regenerative medicine mesenchymal stem cells mesenchymal stromal cells Wharton’s jelly mesenchymal stem cells |
| url | https://www.mdpi.com/1424-8247/14/11/1090 |
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