Erectile Dysfunction, Hormone Levels, Inflammation in Male Patients with Metabolic Syndrome
Background and Objective: The overall prevalence of metabolic syndrome (MetS) and obesity in male Taiwanese is very high, but the impacts on MetS, sexuality and sex hormones, inflammation markers in male erectile dysfunction (ED) are not entirely clear in relevance. This study aim is to investigate...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MRE Press
2018-11-01
|
| Series: | Journal of Men's Health |
| Subjects: | |
| Online Access: | http://www.jomh.org/index.php/JMH/article/view/99 |
| _version_ | 1797326924499910656 |
|---|---|
| author | Jian-Kang Chao Mi-Chia Ma I-Hsin Candy Chao |
| author_facet | Jian-Kang Chao Mi-Chia Ma I-Hsin Candy Chao |
| author_sort | Jian-Kang Chao |
| collection | DOAJ |
| description | Background and Objective: The overall prevalence of metabolic syndrome (MetS) and obesity in male Taiwanese is very high, but the impacts on MetS, sexuality and sex hormones, inflammation markers in male erectile dysfunction (ED) are not entirely clear in relevance. This study aim is to investigate males with MetS and its components, sex hormones, inflammatory risk factors, sexuality and ED correlation.
Material and Methods: This was a cross-sectional study of 89 male participants, and data collected included demographic data, biochemistry, sex hormones, inflammatory risk factors and International Index of Erectile Function (IIEF-15) questionnaire. Descriptive analysis, difference analysis, and logistic regression model were used to identify relevant variables that may affect ED.
Result: Among our 89 subjects, 46 had MetS (51.7%) and 31 subjects with MetS had ED (67.4%). The presence of MetS had a significant correlation with lower IIEF-ED scores, lower intercourse satisfaction scores, lower total testosterone (TT) serum level (p<0.01) and also presence of MetS had a significant correlation with higher D-dimer, fibrinogen and CRP serum level. The results also showed that the greater the number of MetS components had the higher the prevalence of ED and the higher the abnormal CRP, fibrinogen and D-dimer (p<0.05). After adjusting for age, we used sexual desire dysfunction, Met S and TT abnormal to run the logistic regression model for predictors of ED, and the analysis showed that there was a significant difference for sexual desire dysfunction (OR=8.845, 95% CI=2.203- 35.516, P=0.002), Met S (OR=4.1009.70, 95% CI=1.343- 12.520, P=0.013) and TT abnormal (OR=3.287, 95% CI=1.022- 10.570, P=0.046).
Conclusion: To prevent the development of ED, we should encourage a change in lifestyle to prevent the development of MetS, and early identification and treatment of MetS risk factors might be helpful to prevent ED and secondary cardiovascular disease, including diet and lifestyle interventions.聆聽
以拼音方式閱讀 |
| first_indexed | 2024-03-08T06:31:11Z |
| format | Article |
| id | doaj.art-500f877f04ab4082a18192abbeeecb07 |
| institution | Directory Open Access Journal |
| issn | 1875-6859 |
| language | English |
| last_indexed | 2024-03-08T06:31:11Z |
| publishDate | 2018-11-01 |
| publisher | MRE Press |
| record_format | Article |
| series | Journal of Men's Health |
| spelling | doaj.art-500f877f04ab4082a18192abbeeecb072024-02-03T11:30:13ZengMRE PressJournal of Men's Health1875-68592018-11-0114410.22374/1875-6859.14.4.2Erectile Dysfunction, Hormone Levels, Inflammation in Male Patients with Metabolic SyndromeJian-Kang Chao0Mi-Chia Ma1I-Hsin Candy Chao2Yuli branch, Taipei Veterans General HospitalNational Cheng Kung UniversityUniversity of Technology Sydney, Sydney, AustraliaBackground and Objective: The overall prevalence of metabolic syndrome (MetS) and obesity in male Taiwanese is very high, but the impacts on MetS, sexuality and sex hormones, inflammation markers in male erectile dysfunction (ED) are not entirely clear in relevance. This study aim is to investigate males with MetS and its components, sex hormones, inflammatory risk factors, sexuality and ED correlation. Material and Methods: This was a cross-sectional study of 89 male participants, and data collected included demographic data, biochemistry, sex hormones, inflammatory risk factors and International Index of Erectile Function (IIEF-15) questionnaire. Descriptive analysis, difference analysis, and logistic regression model were used to identify relevant variables that may affect ED. Result: Among our 89 subjects, 46 had MetS (51.7%) and 31 subjects with MetS had ED (67.4%). The presence of MetS had a significant correlation with lower IIEF-ED scores, lower intercourse satisfaction scores, lower total testosterone (TT) serum level (p<0.01) and also presence of MetS had a significant correlation with higher D-dimer, fibrinogen and CRP serum level. The results also showed that the greater the number of MetS components had the higher the prevalence of ED and the higher the abnormal CRP, fibrinogen and D-dimer (p<0.05). After adjusting for age, we used sexual desire dysfunction, Met S and TT abnormal to run the logistic regression model for predictors of ED, and the analysis showed that there was a significant difference for sexual desire dysfunction (OR=8.845, 95% CI=2.203- 35.516, P=0.002), Met S (OR=4.1009.70, 95% CI=1.343- 12.520, P=0.013) and TT abnormal (OR=3.287, 95% CI=1.022- 10.570, P=0.046). Conclusion: To prevent the development of ED, we should encourage a change in lifestyle to prevent the development of MetS, and early identification and treatment of MetS risk factors might be helpful to prevent ED and secondary cardiovascular disease, including diet and lifestyle interventions.聆聽 以拼音方式閱讀http://www.jomh.org/index.php/JMH/article/view/99Erectile dysfunction; Metabolic syndrome; International Index of Erectile Function; Testosterone; Inflammatory risk factors |
| spellingShingle | Jian-Kang Chao Mi-Chia Ma I-Hsin Candy Chao Erectile Dysfunction, Hormone Levels, Inflammation in Male Patients with Metabolic Syndrome Journal of Men's Health Erectile dysfunction; Metabolic syndrome; International Index of Erectile Function; Testosterone; Inflammatory risk factors |
| title | Erectile Dysfunction, Hormone Levels, Inflammation in Male Patients with Metabolic Syndrome |
| title_full | Erectile Dysfunction, Hormone Levels, Inflammation in Male Patients with Metabolic Syndrome |
| title_fullStr | Erectile Dysfunction, Hormone Levels, Inflammation in Male Patients with Metabolic Syndrome |
| title_full_unstemmed | Erectile Dysfunction, Hormone Levels, Inflammation in Male Patients with Metabolic Syndrome |
| title_short | Erectile Dysfunction, Hormone Levels, Inflammation in Male Patients with Metabolic Syndrome |
| title_sort | erectile dysfunction hormone levels inflammation in male patients with metabolic syndrome |
| topic | Erectile dysfunction; Metabolic syndrome; International Index of Erectile Function; Testosterone; Inflammatory risk factors |
| url | http://www.jomh.org/index.php/JMH/article/view/99 |
| work_keys_str_mv | AT jiankangchao erectiledysfunctionhormonelevelsinflammationinmalepatientswithmetabolicsyndrome AT michiama erectiledysfunctionhormonelevelsinflammationinmalepatientswithmetabolicsyndrome AT ihsincandychao erectiledysfunctionhormonelevelsinflammationinmalepatientswithmetabolicsyndrome |