The role of chemotherapy in the management of resectable colorectal cancer
Adjuvant chemotherapy has been established as the standard of care for patients with node-positive resected colon cancer. 5-fluorouracil modulated with leucovorin given for six months is currently the most widely accepted "standard" regimen. The role of adjuvant chemotherapy in stage II re...
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| Format: | Article |
| Language: | English |
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Institute of Oncology, Sremska Kamenica, Serbia
2003-01-01
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| Series: | Archive of Oncology |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-7310/2003/0354-73100303161R.pdf |
| _version_ | 1818542191961702400 |
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| author | Radosavljević Davorin Z. Tomašević Zorica I. Popov Ivan Jelić Svetislav B. |
| author_facet | Radosavljević Davorin Z. Tomašević Zorica I. Popov Ivan Jelić Svetislav B. |
| author_sort | Radosavljević Davorin Z. |
| collection | DOAJ |
| description | Adjuvant chemotherapy has been established as the standard of care for patients with node-positive resected colon cancer. 5-fluorouracil modulated with leucovorin given for six months is currently the most widely accepted "standard" regimen. The role of adjuvant chemotherapy in stage II remain investigational and some prognostic indicators that correlate with higher risk for subsequent recurrence may be used for these patients when consider adjuvant chemotherapy. Other investigational approaches include regional portal vein infusion and intraperitoneal therapy, immunotherapy, and new drugs, with proven activity in metastatic disease. Patients older than 70 years are also candidate for adjuvant therapy of colorectal cancer. Adjuvant chemotherapy of rectal cancer is often associated with radiotherapy and enhances local control seen with radiotherapy and improves survival of these patients. |
| first_indexed | 2024-12-11T22:18:53Z |
| format | Article |
| id | doaj.art-5010036a08d64451966bd8bdf770155a |
| institution | Directory Open Access Journal |
| issn | 0354-7310 |
| language | English |
| last_indexed | 2024-12-11T22:18:53Z |
| publishDate | 2003-01-01 |
| publisher | Institute of Oncology, Sremska Kamenica, Serbia |
| record_format | Article |
| series | Archive of Oncology |
| spelling | doaj.art-5010036a08d64451966bd8bdf770155a2022-12-22T00:48:31ZengInstitute of Oncology, Sremska Kamenica, SerbiaArchive of Oncology0354-73102003-01-0111316116310.2298/AOO0303161RThe role of chemotherapy in the management of resectable colorectal cancerRadosavljević Davorin Z.Tomašević Zorica I.Popov IvanJelić Svetislav B.Adjuvant chemotherapy has been established as the standard of care for patients with node-positive resected colon cancer. 5-fluorouracil modulated with leucovorin given for six months is currently the most widely accepted "standard" regimen. The role of adjuvant chemotherapy in stage II remain investigational and some prognostic indicators that correlate with higher risk for subsequent recurrence may be used for these patients when consider adjuvant chemotherapy. Other investigational approaches include regional portal vein infusion and intraperitoneal therapy, immunotherapy, and new drugs, with proven activity in metastatic disease. Patients older than 70 years are also candidate for adjuvant therapy of colorectal cancer. Adjuvant chemotherapy of rectal cancer is often associated with radiotherapy and enhances local control seen with radiotherapy and improves survival of these patients.http://www.doiserbia.nb.rs/img/doi/0354-7310/2003/0354-73100303161R.pdfcolorectal neoplasmscarcinomacombined modality therapysurgerychemotherapyadjuvantantineoplastic combined chemotherapy protocols |
| spellingShingle | Radosavljević Davorin Z. Tomašević Zorica I. Popov Ivan Jelić Svetislav B. The role of chemotherapy in the management of resectable colorectal cancer Archive of Oncology colorectal neoplasms carcinoma combined modality therapy surgery chemotherapy adjuvant antineoplastic combined chemotherapy protocols |
| title | The role of chemotherapy in the management of resectable colorectal cancer |
| title_full | The role of chemotherapy in the management of resectable colorectal cancer |
| title_fullStr | The role of chemotherapy in the management of resectable colorectal cancer |
| title_full_unstemmed | The role of chemotherapy in the management of resectable colorectal cancer |
| title_short | The role of chemotherapy in the management of resectable colorectal cancer |
| title_sort | role of chemotherapy in the management of resectable colorectal cancer |
| topic | colorectal neoplasms carcinoma combined modality therapy surgery chemotherapy adjuvant antineoplastic combined chemotherapy protocols |
| url | http://www.doiserbia.nb.rs/img/doi/0354-7310/2003/0354-73100303161R.pdf |
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