An activator of G protein-coupled receptor and MEK1/2-ERK1/2 signaling inhibits HIV-1 replication by altering viral RNA processing.

An activator of G protein-coupled receptor and MEK1/2-ERK1/2 signaling inhibits HIV-1 replication by altering viral RNA processing.

The ability of HIV-1 to evolve resistance to combined antiretroviral therapies (cARTs) has stimulated research into alternative means of controlling this infection. We assayed >60 modulators of RNA alternative splicing (AS) to identify new inhibitors of HIV-1 RNA processing-a segment of the viral...

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Bibliographic Details
Main Authors: Raymond W Wong, Ahalya Balachandran, Peter K Cheung, Ran Cheng, Qun Pan, Peter Stoilov, P Richard Harrigan, Benjamin J Blencowe, Donald R Branch, Alan Cochrane
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008307

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