Integration of hydrogels in microfabrication processes for bioelectronic medicine: Progress and outlook

Recent research aiming at the development of electroceuticals for the treatment of medical conditions such as degenerative diseases, cardiac arrhythmia and chronic pain, has given rise to microfabricated implanted bioelectronic devices capable of interacting with host biological tissues in synergist...

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Main Authors: Saloua Saghir, Kristin Imenes, Giuseppe Schiavone
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1150147/full
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author Saloua Saghir
Kristin Imenes
Giuseppe Schiavone
author_facet Saloua Saghir
Kristin Imenes
Giuseppe Schiavone
author_sort Saloua Saghir
collection DOAJ
description Recent research aiming at the development of electroceuticals for the treatment of medical conditions such as degenerative diseases, cardiac arrhythmia and chronic pain, has given rise to microfabricated implanted bioelectronic devices capable of interacting with host biological tissues in synergistic modalities. Owing to their multimodal affinity to biological tissues, hydrogels have emerged as promising interface materials for bioelectronic devices. Here, we review the state-of-the-art and forefront in the techniques used by research groups for the integration of hydrogels into the microfabrication processes of bioelectronic devices, and present the manufacturability challenges to unlock their further clinical deployment.
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spelling doaj.art-5011598cb042471295f72239350947a52023-03-24T05:18:02ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-03-011110.3389/fbioe.2023.11501471150147Integration of hydrogels in microfabrication processes for bioelectronic medicine: Progress and outlookSaloua SaghirKristin ImenesGiuseppe SchiavoneRecent research aiming at the development of electroceuticals for the treatment of medical conditions such as degenerative diseases, cardiac arrhythmia and chronic pain, has given rise to microfabricated implanted bioelectronic devices capable of interacting with host biological tissues in synergistic modalities. Owing to their multimodal affinity to biological tissues, hydrogels have emerged as promising interface materials for bioelectronic devices. Here, we review the state-of-the-art and forefront in the techniques used by research groups for the integration of hydrogels into the microfabrication processes of bioelectronic devices, and present the manufacturability challenges to unlock their further clinical deployment.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1150147/fullhydrogelsbioelectronic interfacesmicrofabrication processesimplantable medical devicesbiomaterialssoft bioelectronics
spellingShingle Saloua Saghir
Kristin Imenes
Giuseppe Schiavone
Integration of hydrogels in microfabrication processes for bioelectronic medicine: Progress and outlook
Frontiers in Bioengineering and Biotechnology
hydrogels
bioelectronic interfaces
microfabrication processes
implantable medical devices
biomaterials
soft bioelectronics
title Integration of hydrogels in microfabrication processes for bioelectronic medicine: Progress and outlook
title_full Integration of hydrogels in microfabrication processes for bioelectronic medicine: Progress and outlook
title_fullStr Integration of hydrogels in microfabrication processes for bioelectronic medicine: Progress and outlook
title_full_unstemmed Integration of hydrogels in microfabrication processes for bioelectronic medicine: Progress and outlook
title_short Integration of hydrogels in microfabrication processes for bioelectronic medicine: Progress and outlook
title_sort integration of hydrogels in microfabrication processes for bioelectronic medicine progress and outlook
topic hydrogels
bioelectronic interfaces
microfabrication processes
implantable medical devices
biomaterials
soft bioelectronics
url https://www.frontiersin.org/articles/10.3389/fbioe.2023.1150147/full
work_keys_str_mv AT salouasaghir integrationofhydrogelsinmicrofabricationprocessesforbioelectronicmedicineprogressandoutlook
AT kristinimenes integrationofhydrogelsinmicrofabricationprocessesforbioelectronicmedicineprogressandoutlook
AT giuseppeschiavone integrationofhydrogelsinmicrofabricationprocessesforbioelectronicmedicineprogressandoutlook