miR-874: An Important Regulator in Human Diseases
miR-874 is located at 5q31.2, which is frequently deleted in cancer. miR-874 is downregulated in 22 types of cancers and aberrantly expressed in 18 types of non-cancer diseases. The dysfunction of miR-874 is not only closely related to the diagnosis and prognosis of tumor patients but also plays an...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-04-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.784968/full |
| _version_ | 1818348839939080192 |
|---|---|
| author | Qiudan Zhang Qiudan Zhang Chenming Zhong Qianqian Yan Ling-hui Zeng Wei Gao Shiwei Duan Shiwei Duan |
| author_facet | Qiudan Zhang Qiudan Zhang Chenming Zhong Qianqian Yan Ling-hui Zeng Wei Gao Shiwei Duan Shiwei Duan |
| author_sort | Qiudan Zhang |
| collection | DOAJ |
| description | miR-874 is located at 5q31.2, which is frequently deleted in cancer. miR-874 is downregulated in 22 types of cancers and aberrantly expressed in 18 types of non-cancer diseases. The dysfunction of miR-874 is not only closely related to the diagnosis and prognosis of tumor patients but also plays an important role in the efficacy of tumor chemotherapy drugs. miR-874 participates in the ceRNA network of long non-coding RNAs or circular RNAs, which is closely related to the occurrence and development of cancer and other non-cancer diseases. In addition, miR-874 is also involved in the regulation of multiple signaling pathways, including the Wnt/β-catenin signaling pathway, Hippo signaling pathway, PI3K/AKT signaling pathway, JAK/STAT signaling pathway, and Hedgehog signaling pathway. This review summarizes the molecular functions of miR-874 in the biological processes of tumor cell survival, apoptosis, differentiation, and tumorigenesis, and reveal the value of miR-874 as a cancer biomarker in tumor diagnosis and prognosis. Future work is necessary to explore the potential clinical application of miR-874 in chemotherapy resistance. |
| first_indexed | 2024-12-13T17:56:26Z |
| format | Article |
| id | doaj.art-5011e9c5be474987beda4701db79506f |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-13T17:56:26Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-5011e9c5be474987beda4701db79506f2022-12-21T23:36:22ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-04-011010.3389/fcell.2022.784968784968miR-874: An Important Regulator in Human DiseasesQiudan Zhang0Qiudan Zhang1Chenming Zhong2Qianqian Yan3Ling-hui Zeng4Wei Gao5Shiwei Duan6Shiwei Duan7School of Medicine, Zhejiang University City College, Hangzhou, ChinaMedical Genetics Center, School of Medicine, Ningbo University, Ningbo, ChinaMedical Genetics Center, School of Medicine, Ningbo University, Ningbo, ChinaMedical Genetics Center, School of Medicine, Ningbo University, Ningbo, ChinaSchool of Medicine, Zhejiang University City College, Hangzhou, ChinaSchool of Medicine, Zhejiang University City College, Hangzhou, ChinaSchool of Medicine, Zhejiang University City College, Hangzhou, ChinaMedical Genetics Center, School of Medicine, Ningbo University, Ningbo, ChinamiR-874 is located at 5q31.2, which is frequently deleted in cancer. miR-874 is downregulated in 22 types of cancers and aberrantly expressed in 18 types of non-cancer diseases. The dysfunction of miR-874 is not only closely related to the diagnosis and prognosis of tumor patients but also plays an important role in the efficacy of tumor chemotherapy drugs. miR-874 participates in the ceRNA network of long non-coding RNAs or circular RNAs, which is closely related to the occurrence and development of cancer and other non-cancer diseases. In addition, miR-874 is also involved in the regulation of multiple signaling pathways, including the Wnt/β-catenin signaling pathway, Hippo signaling pathway, PI3K/AKT signaling pathway, JAK/STAT signaling pathway, and Hedgehog signaling pathway. This review summarizes the molecular functions of miR-874 in the biological processes of tumor cell survival, apoptosis, differentiation, and tumorigenesis, and reveal the value of miR-874 as a cancer biomarker in tumor diagnosis and prognosis. Future work is necessary to explore the potential clinical application of miR-874 in chemotherapy resistance.https://www.frontiersin.org/articles/10.3389/fcell.2022.784968/fullmiR-874cancertumor suppressornon-cancerdiagnosisprognosis |
| spellingShingle | Qiudan Zhang Qiudan Zhang Chenming Zhong Qianqian Yan Ling-hui Zeng Wei Gao Shiwei Duan Shiwei Duan miR-874: An Important Regulator in Human Diseases Frontiers in Cell and Developmental Biology miR-874 cancer tumor suppressor non-cancer diagnosis prognosis |
| title | miR-874: An Important Regulator in Human Diseases |
| title_full | miR-874: An Important Regulator in Human Diseases |
| title_fullStr | miR-874: An Important Regulator in Human Diseases |
| title_full_unstemmed | miR-874: An Important Regulator in Human Diseases |
| title_short | miR-874: An Important Regulator in Human Diseases |
| title_sort | mir 874 an important regulator in human diseases |
| topic | miR-874 cancer tumor suppressor non-cancer diagnosis prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.784968/full |
| work_keys_str_mv | AT qiudanzhang mir874animportantregulatorinhumandiseases AT qiudanzhang mir874animportantregulatorinhumandiseases AT chenmingzhong mir874animportantregulatorinhumandiseases AT qianqianyan mir874animportantregulatorinhumandiseases AT linghuizeng mir874animportantregulatorinhumandiseases AT weigao mir874animportantregulatorinhumandiseases AT shiweiduan mir874animportantregulatorinhumandiseases AT shiweiduan mir874animportantregulatorinhumandiseases |