Influence of Organic Matter on the Sorption of Cefdinir, Memantine and Praziquantel on Different Soil and Sediment Samples
Pharmaceuticals are known for their great effects and applications in the treatment and suppression of various diseases in human and veterinary medicine. The development and modernization of science and technologies have led to a constant increase in the production and consumption of various classes...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/22/8008 |
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| author | Dragana Mutavdžić Pavlović Kristina Tolić Čop Helena Prskalo Mislav Runje |
| author_facet | Dragana Mutavdžić Pavlović Kristina Tolić Čop Helena Prskalo Mislav Runje |
| author_sort | Dragana Mutavdžić Pavlović |
| collection | DOAJ |
| description | Pharmaceuticals are known for their great effects and applications in the treatment and suppression of various diseases in human and veterinary medicine. The development and modernization of science and technologies have led to a constant increase in the production and consumption of various classes of pharmaceuticals, so they pose a threat to the environment, which can be subjected to the sorption process on the solid phase. The efficiency of sorption is determined by various parameters, of which the physicochemical properties of the compound and the sorbent are very important. One of these parameters that determine pharmaceutical mobility in soil or sediment is the soil–water partition coefficient normalized to organic carbon (<i>K</i><sub>oc</sub>), whose determination was the purpose of this study. The influence of organic matter, suspended in an aqueous solution of pharmaceutical (more precisely: cefdinir, memantine, and praziquantel), was studied for five different types of soil and sediment samples from Croatia. The linear, Freundlich, and Dubinin–Raduskevich sorption isotherms were used to determine specific constants such as the partition coefficient <i>K</i><sub>d</sub>, which directly describes the strength of sorbate and sorbent binding. The linear model proved to be the best with the highest correlation coefficients, <i>R</i><sup>2</sup> > 0.99. For all three pharmaceuticals, a positive correlation between sorption affinity described by <i>K</i><sub>d</sub> and <i>K</i><sub>oc</sub> and the amount of organic matter was demonstrated. |
| first_indexed | 2024-03-09T18:06:50Z |
| format | Article |
| id | doaj.art-5013013f21784eeca4fd40af130b4597 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T18:06:50Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5013013f21784eeca4fd40af130b45972023-11-24T09:24:59ZengMDPI AGMolecules1420-30492022-11-012722800810.3390/molecules27228008Influence of Organic Matter on the Sorption of Cefdinir, Memantine and Praziquantel on Different Soil and Sediment SamplesDragana Mutavdžić Pavlović0Kristina Tolić Čop1Helena Prskalo2Mislav Runje3Department of Analytical Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Analytical Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Analytical Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, 10000 Zagreb, CroatiaPliva Croatia TAPI R&D, 10000 Zagreb, CroatiaPharmaceuticals are known for their great effects and applications in the treatment and suppression of various diseases in human and veterinary medicine. The development and modernization of science and technologies have led to a constant increase in the production and consumption of various classes of pharmaceuticals, so they pose a threat to the environment, which can be subjected to the sorption process on the solid phase. The efficiency of sorption is determined by various parameters, of which the physicochemical properties of the compound and the sorbent are very important. One of these parameters that determine pharmaceutical mobility in soil or sediment is the soil–water partition coefficient normalized to organic carbon (<i>K</i><sub>oc</sub>), whose determination was the purpose of this study. The influence of organic matter, suspended in an aqueous solution of pharmaceutical (more precisely: cefdinir, memantine, and praziquantel), was studied for five different types of soil and sediment samples from Croatia. The linear, Freundlich, and Dubinin–Raduskevich sorption isotherms were used to determine specific constants such as the partition coefficient <i>K</i><sub>d</sub>, which directly describes the strength of sorbate and sorbent binding. The linear model proved to be the best with the highest correlation coefficients, <i>R</i><sup>2</sup> > 0.99. For all three pharmaceuticals, a positive correlation between sorption affinity described by <i>K</i><sub>d</sub> and <i>K</i><sub>oc</sub> and the amount of organic matter was demonstrated.https://www.mdpi.com/1420-3049/27/22/8008sorptionmemantinecefdinirpraziquantelorganic matterdistribution coefficient |
| spellingShingle | Dragana Mutavdžić Pavlović Kristina Tolić Čop Helena Prskalo Mislav Runje Influence of Organic Matter on the Sorption of Cefdinir, Memantine and Praziquantel on Different Soil and Sediment Samples Molecules sorption memantine cefdinir praziquantel organic matter distribution coefficient |
| title | Influence of Organic Matter on the Sorption of Cefdinir, Memantine and Praziquantel on Different Soil and Sediment Samples |
| title_full | Influence of Organic Matter on the Sorption of Cefdinir, Memantine and Praziquantel on Different Soil and Sediment Samples |
| title_fullStr | Influence of Organic Matter on the Sorption of Cefdinir, Memantine and Praziquantel on Different Soil and Sediment Samples |
| title_full_unstemmed | Influence of Organic Matter on the Sorption of Cefdinir, Memantine and Praziquantel on Different Soil and Sediment Samples |
| title_short | Influence of Organic Matter on the Sorption of Cefdinir, Memantine and Praziquantel on Different Soil and Sediment Samples |
| title_sort | influence of organic matter on the sorption of cefdinir memantine and praziquantel on different soil and sediment samples |
| topic | sorption memantine cefdinir praziquantel organic matter distribution coefficient |
| url | https://www.mdpi.com/1420-3049/27/22/8008 |
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