Microglial STAT1-sufficiency is required for resistance to toxoplasmic encephalitis.

Microglial STAT1-sufficiency is required for resistance to toxoplasmic encephalitis.

Toxoplasma gondii is a ubiquitous intracellular protozoan parasite that establishes a life-long chronic infection largely restricted to the central nervous system (CNS). Constant immune pressure, notably IFN-γ-STAT1 signaling, is required for preventing fatal pathology during T. gondii infection. He...

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Bibliographic Details
Main Authors: Maureen N Cowan, Michael A Kovacs, Ish Sethi, Isaac W Babcock, Katherine Still, Samantha J Batista, Carleigh A O'Brien, Jeremy A Thompson, Lydia A Sibley, Sydney A Labuzan, Tajie H Harris
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010637

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