Metformin regulates myoblast differentiation through an AMPK-dependent mechanism.

Metformin regulates myoblast differentiation through an AMPK-dependent mechanism.

This study aims to investigate how metformin (Met) affects muscle tissue by evaluating the drug effects on proliferating, differentiating, and differentiated C2C12 cells. Moreover, we also investigated the role of 5'-adenosine monophosphate-activated protein kinase (AMPK) in the mechanism of ac...

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Bibliographic Details
Main Authors: Eleonora Maniscalco, Giuliana Abbadessa, Magalì Giordano, Loredana Grasso, Paolo Borrione, Silvia Racca
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0281718

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