Altered individual behavioral and EEG parameters are related to the EDSS score in relapsing-remitting multiple sclerosis patients.
Functional neuroanatomy of cognitive impairment in multiple sclerosis is currently still a challenge. During the progression of the disease, several cognitive mechanisms deteriorate thus diminishing the patient's quality of life. A primary objective in the cognitive assessment of multiple scler...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0219594 |
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| author | Manuel Vázquez-Marrufo Alejandro Galvao-Carmona Rocio Caballero-Díaz Monica Borges Maria Dolores Paramo Maria Luisa Benítez-Lugo Juan Luis Ruiz-Peña Guillermo Izquierdo |
| author_facet | Manuel Vázquez-Marrufo Alejandro Galvao-Carmona Rocio Caballero-Díaz Monica Borges Maria Dolores Paramo Maria Luisa Benítez-Lugo Juan Luis Ruiz-Peña Guillermo Izquierdo |
| author_sort | Manuel Vázquez-Marrufo |
| collection | DOAJ |
| description | Functional neuroanatomy of cognitive impairment in multiple sclerosis is currently still a challenge. During the progression of the disease, several cognitive mechanisms deteriorate thus diminishing the patient's quality of life. A primary objective in the cognitive assessment of multiple sclerosis (MS) patients is to find reliable measures utilizing diverse neuroimaging techniques. Moreover, especially relevant in the clinical environment is finding technical approaches that could be applied to individual participants and not only for group analysis. A 64-channel electroencephalographic recording (EEG) was made with thirty participants divided into three groups of equivalent size (N = 10) (healthy control, low-EDSS (1-2.5) and moderate-EDSS (4-6)). Correlation analysis was applied to multiple measures: behavior, neuropsychological tests (Paced Auditory Serial Addition Test, 3 seconds (PASAT-3s) and the Symbol Digit Modality Test (SDMT)), Expanded Disability Status Scale (EDSS), even-related potential (P3) and event-related desynchronization (ERD) parameters and the correlation scores between individual participant's P3/ERD maps and the healthy grand average P3/ERDmaps. Statistical analysis showed that diverse parameters exhibited significant correlations. A remarkable correlation was the moderate score found between SDMT and EDSS (r = -0.679, p = 0.0009). However, the strongest correlation was between the value of integrated measures (reaction time, P3 and ERD latency) and EDSS (r = 0.699, p = 0.0006). In regard to correlations for grand average maps between groups, the P3 component exhibited a lower score according to a more deteriorated condition (higher EDSS). In contrast, ERD maps remained stable with an increase of EDSS. Lastly, a Z-transformation of individual values of all variables included in the study exhibited heterogeneity in cognitive alterations in the multiple sclerosis participants. |
| first_indexed | 2024-12-21T10:13:53Z |
| format | Article |
| id | doaj.art-5017855317154e67ab9f017e43ecd622 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T10:13:53Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5017855317154e67ab9f017e43ecd6222022-12-21T19:07:39ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01147e021959410.1371/journal.pone.0219594Altered individual behavioral and EEG parameters are related to the EDSS score in relapsing-remitting multiple sclerosis patients.Manuel Vázquez-MarrufoAlejandro Galvao-CarmonaRocio Caballero-DíazMonica BorgesMaria Dolores ParamoMaria Luisa Benítez-LugoJuan Luis Ruiz-PeñaGuillermo IzquierdoFunctional neuroanatomy of cognitive impairment in multiple sclerosis is currently still a challenge. During the progression of the disease, several cognitive mechanisms deteriorate thus diminishing the patient's quality of life. A primary objective in the cognitive assessment of multiple sclerosis (MS) patients is to find reliable measures utilizing diverse neuroimaging techniques. Moreover, especially relevant in the clinical environment is finding technical approaches that could be applied to individual participants and not only for group analysis. A 64-channel electroencephalographic recording (EEG) was made with thirty participants divided into three groups of equivalent size (N = 10) (healthy control, low-EDSS (1-2.5) and moderate-EDSS (4-6)). Correlation analysis was applied to multiple measures: behavior, neuropsychological tests (Paced Auditory Serial Addition Test, 3 seconds (PASAT-3s) and the Symbol Digit Modality Test (SDMT)), Expanded Disability Status Scale (EDSS), even-related potential (P3) and event-related desynchronization (ERD) parameters and the correlation scores between individual participant's P3/ERD maps and the healthy grand average P3/ERDmaps. Statistical analysis showed that diverse parameters exhibited significant correlations. A remarkable correlation was the moderate score found between SDMT and EDSS (r = -0.679, p = 0.0009). However, the strongest correlation was between the value of integrated measures (reaction time, P3 and ERD latency) and EDSS (r = 0.699, p = 0.0006). In regard to correlations for grand average maps between groups, the P3 component exhibited a lower score according to a more deteriorated condition (higher EDSS). In contrast, ERD maps remained stable with an increase of EDSS. Lastly, a Z-transformation of individual values of all variables included in the study exhibited heterogeneity in cognitive alterations in the multiple sclerosis participants.https://doi.org/10.1371/journal.pone.0219594 |
| spellingShingle | Manuel Vázquez-Marrufo Alejandro Galvao-Carmona Rocio Caballero-Díaz Monica Borges Maria Dolores Paramo Maria Luisa Benítez-Lugo Juan Luis Ruiz-Peña Guillermo Izquierdo Altered individual behavioral and EEG parameters are related to the EDSS score in relapsing-remitting multiple sclerosis patients. PLoS ONE |
| title | Altered individual behavioral and EEG parameters are related to the EDSS score in relapsing-remitting multiple sclerosis patients. |
| title_full | Altered individual behavioral and EEG parameters are related to the EDSS score in relapsing-remitting multiple sclerosis patients. |
| title_fullStr | Altered individual behavioral and EEG parameters are related to the EDSS score in relapsing-remitting multiple sclerosis patients. |
| title_full_unstemmed | Altered individual behavioral and EEG parameters are related to the EDSS score in relapsing-remitting multiple sclerosis patients. |
| title_short | Altered individual behavioral and EEG parameters are related to the EDSS score in relapsing-remitting multiple sclerosis patients. |
| title_sort | altered individual behavioral and eeg parameters are related to the edss score in relapsing remitting multiple sclerosis patients |
| url | https://doi.org/10.1371/journal.pone.0219594 |
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