Serum trace metals in Pre-Eclamptic Nigerians
Background: The role of trace metals in Pathogenesis of Pre-eclampsia has received insufficient attention in Nigeria. Materials and Methods: We examined the effect of serum levels of some trace metals; selenium (Se), zinc (Zn), copper (Cu), cobalt (Co), and manganese (Mn) in the development of pr...
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Format: | Article |
Language: | English |
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Manipal College of Medical Sciences, Pokhara
2016-01-01
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Series: | Asian Journal of Medical Sciences |
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Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/13027 |
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author | Ikechukwu Chidiebere Ikaraoha |
author_facet | Ikechukwu Chidiebere Ikaraoha |
author_sort | Ikechukwu Chidiebere Ikaraoha |
collection | DOAJ |
description | Background: The role of trace metals in Pathogenesis of Pre-eclampsia has received insufficient attention in Nigeria.
Materials and Methods: We examined the effect of serum levels of some trace metals; selenium (Se), zinc (Zn), copper (Cu), cobalt (Co), and manganese (Mn) in the development of pre-eclampsia in Nigeria. Blood samples were collected from 59 pre-eclamptic, 150 normal pregnant and 122 non pregnant women. Serum Se, Zn, Cu, Co and Mn were determined by AAS.
Results: Result shows significantly lower serum Se, Zn, Cu, Cu: Zn ratio, Co and Mn in pre-eclamptics compared to normal pregnant women (p<0.001). Comparison of normal pregnant women and controls showed non significant difference in the zinc level (P>0.05), significantly lower levels of serum Se, Co, Mn (p<0.00011, p=0.0022, p<0.0001 respectively) and significantly raised copper level (p<0.001) in normal pregnant women compared to controls. Serum Se, Zn, Co and Mn were significantly lower (p<0.001) while serum copper and Cu: Zn ratio were significantly higher (p<0.001) in pregnant women compared to controls. ANOVA shows significant progressive decreases in serum Se, Zn Co and Mn, from controls to normal pregnant women and pre-eclamptics (p<0.0001).
Conclusion: Decreases in serum level of Se, Zn, Cu, Cu: Zn ratio, Co and Mn may play important role in the pathogenesis of pre-eclampsia. |
first_indexed | 2024-12-12T23:39:05Z |
format | Article |
id | doaj.art-501a64793e1846e98ff9789caebdbc60 |
institution | Directory Open Access Journal |
issn | 2467-9100 2091-0576 |
language | English |
last_indexed | 2024-12-12T23:39:05Z |
publishDate | 2016-01-01 |
publisher | Manipal College of Medical Sciences, Pokhara |
record_format | Article |
series | Asian Journal of Medical Sciences |
spelling | doaj.art-501a64793e1846e98ff9789caebdbc602022-12-22T00:07:17ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762016-01-01737883https://doi.org/10.3126/ajms.v7i3.13027Serum trace metals in Pre-Eclamptic NigeriansIkechukwu Chidiebere Ikaraoha 0Senior Lecturer, Chemical Pathology Unit, Department of Medical Laboratory Science Faculty of Health Science Imo state University, Owerri http://orcid.org/0000-0003-0441-8693Background: The role of trace metals in Pathogenesis of Pre-eclampsia has received insufficient attention in Nigeria. Materials and Methods: We examined the effect of serum levels of some trace metals; selenium (Se), zinc (Zn), copper (Cu), cobalt (Co), and manganese (Mn) in the development of pre-eclampsia in Nigeria. Blood samples were collected from 59 pre-eclamptic, 150 normal pregnant and 122 non pregnant women. Serum Se, Zn, Cu, Co and Mn were determined by AAS. Results: Result shows significantly lower serum Se, Zn, Cu, Cu: Zn ratio, Co and Mn in pre-eclamptics compared to normal pregnant women (p<0.001). Comparison of normal pregnant women and controls showed non significant difference in the zinc level (P>0.05), significantly lower levels of serum Se, Co, Mn (p<0.00011, p=0.0022, p<0.0001 respectively) and significantly raised copper level (p<0.001) in normal pregnant women compared to controls. Serum Se, Zn, Co and Mn were significantly lower (p<0.001) while serum copper and Cu: Zn ratio were significantly higher (p<0.001) in pregnant women compared to controls. ANOVA shows significant progressive decreases in serum Se, Zn Co and Mn, from controls to normal pregnant women and pre-eclamptics (p<0.0001). Conclusion: Decreases in serum level of Se, Zn, Cu, Cu: Zn ratio, Co and Mn may play important role in the pathogenesis of pre-eclampsia.https://www.nepjol.info/index.php/AJMS/article/view/13027trace metalspregnant womenpre-eclampsianigeria |
spellingShingle | Ikechukwu Chidiebere Ikaraoha Serum trace metals in Pre-Eclamptic Nigerians Asian Journal of Medical Sciences trace metals pregnant women pre-eclampsia nigeria |
title | Serum trace metals in Pre-Eclamptic Nigerians |
title_full | Serum trace metals in Pre-Eclamptic Nigerians |
title_fullStr | Serum trace metals in Pre-Eclamptic Nigerians |
title_full_unstemmed | Serum trace metals in Pre-Eclamptic Nigerians |
title_short | Serum trace metals in Pre-Eclamptic Nigerians |
title_sort | serum trace metals in pre eclamptic nigerians |
topic | trace metals pregnant women pre-eclampsia nigeria |
url | https://www.nepjol.info/index.php/AJMS/article/view/13027 |
work_keys_str_mv | AT ikechukwuchidiebereikaraoha serumtracemetalsinpreeclampticnigerians |