The Emerging Epigenetic Role of CD8+T Cells in Autoimmune Diseases: A Systematic Review
Autoimmune diseases are usually complex and multifactorial, characterized by aberrant production of autoreactive immune cells and/or autoantibodies against healthy cells and tissues. However, the pathogenesis of autoimmune diseases has not been clearly elucidated. The activation, differentiation, an...
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Frontiers Media S.A.
2019-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.00856/full |
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| author | Qiancheng Deng Yangyang Luo Yangyang Luo Christopher Chang Haijing Wu Yan Ding Rong Xiao |
| author_facet | Qiancheng Deng Yangyang Luo Yangyang Luo Christopher Chang Haijing Wu Yan Ding Rong Xiao |
| author_sort | Qiancheng Deng |
| collection | DOAJ |
| description | Autoimmune diseases are usually complex and multifactorial, characterized by aberrant production of autoreactive immune cells and/or autoantibodies against healthy cells and tissues. However, the pathogenesis of autoimmune diseases has not been clearly elucidated. The activation, differentiation, and development of CD8+ T cells can be affected by numerous inflammatory cytokines, transcription factors, and chemokines. In recent years, epigenetic modifications have been shown to play an important role in the fate of CD8+ T cells. The discovery of these modifications that contribute to the activation or suppression of CD8+ cells has been concurrent with the increasing evidence that CD8+ T cells play a role in autoimmunity. These relationships have been studied in various autoimmune diseases, including multiple sclerosis (MS), systemic sclerosis (SSc), type 1 diabetes (T1D), Grave's disease (GD), systemic lupus erythematosus (SLE), aplastic anemia (AA), and vitiligo. In each of these diseases, genes that play a role in the proliferation or activation of CD8+ T cells have been found to be affected by epigenetic modifications. Various cytokines, transcription factors, and other regulatory molecules have been found to be differentially methylated in CD8+ T cells in autoimmune diseases. These genes are involved in T cell regulation, including interferons, interleukin (IL),tumor necrosis factor (TNF), as well as linker for activation of T cells (LAT), cytotoxic T-lymphocyte–associated antigen 4 (CTLA4), and adapter proteins. MiRNAs also play a role in the pathogenesis of these diseases and several known miRNAs that are involved in these diseases have also been shown to play a role in CD8+ regulation. |
| first_indexed | 2024-12-22T14:47:22Z |
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| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-22T14:47:22Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Immunology |
| spelling | doaj.art-501c0bb01c9e4c9fada219913e85a6432022-12-21T18:22:24ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-04-011010.3389/fimmu.2019.00856430294The Emerging Epigenetic Role of CD8+T Cells in Autoimmune Diseases: A Systematic ReviewQiancheng Deng0Yangyang Luo1Yangyang Luo2Christopher Chang3Haijing Wu4Yan Ding5Rong Xiao6Hunan Key Laboratory of Medical Epigenetics, Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Medical Epigenetics, Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Dermatology, Hunan Children's Hospital, Changsha, ChinaDivision of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, Davis, CA, United StatesHunan Key Laboratory of Medical Epigenetics, Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Dermatology, Hainan Provincial Dermatology Disease Hospital, Haikou, ChinaHunan Key Laboratory of Medical Epigenetics, Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, ChinaAutoimmune diseases are usually complex and multifactorial, characterized by aberrant production of autoreactive immune cells and/or autoantibodies against healthy cells and tissues. However, the pathogenesis of autoimmune diseases has not been clearly elucidated. The activation, differentiation, and development of CD8+ T cells can be affected by numerous inflammatory cytokines, transcription factors, and chemokines. In recent years, epigenetic modifications have been shown to play an important role in the fate of CD8+ T cells. The discovery of these modifications that contribute to the activation or suppression of CD8+ cells has been concurrent with the increasing evidence that CD8+ T cells play a role in autoimmunity. These relationships have been studied in various autoimmune diseases, including multiple sclerosis (MS), systemic sclerosis (SSc), type 1 diabetes (T1D), Grave's disease (GD), systemic lupus erythematosus (SLE), aplastic anemia (AA), and vitiligo. In each of these diseases, genes that play a role in the proliferation or activation of CD8+ T cells have been found to be affected by epigenetic modifications. Various cytokines, transcription factors, and other regulatory molecules have been found to be differentially methylated in CD8+ T cells in autoimmune diseases. These genes are involved in T cell regulation, including interferons, interleukin (IL),tumor necrosis factor (TNF), as well as linker for activation of T cells (LAT), cytotoxic T-lymphocyte–associated antigen 4 (CTLA4), and adapter proteins. MiRNAs also play a role in the pathogenesis of these diseases and several known miRNAs that are involved in these diseases have also been shown to play a role in CD8+ regulation.https://www.frontiersin.org/article/10.3389/fimmu.2019.00856/fullepigeneticsCD8+T cellsDNA methylationhistone modificationMiRNAsautoimmune diseases |
| spellingShingle | Qiancheng Deng Yangyang Luo Yangyang Luo Christopher Chang Haijing Wu Yan Ding Rong Xiao The Emerging Epigenetic Role of CD8+T Cells in Autoimmune Diseases: A Systematic Review Frontiers in Immunology epigenetics CD8+T cells DNA methylation histone modification MiRNAs autoimmune diseases |
| title | The Emerging Epigenetic Role of CD8+T Cells in Autoimmune Diseases: A Systematic Review |
| title_full | The Emerging Epigenetic Role of CD8+T Cells in Autoimmune Diseases: A Systematic Review |
| title_fullStr | The Emerging Epigenetic Role of CD8+T Cells in Autoimmune Diseases: A Systematic Review |
| title_full_unstemmed | The Emerging Epigenetic Role of CD8+T Cells in Autoimmune Diseases: A Systematic Review |
| title_short | The Emerging Epigenetic Role of CD8+T Cells in Autoimmune Diseases: A Systematic Review |
| title_sort | emerging epigenetic role of cd8 t cells in autoimmune diseases a systematic review |
| topic | epigenetics CD8+T cells DNA methylation histone modification MiRNAs autoimmune diseases |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.00856/full |
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