β-catenin inhibitors in cancer therapeutics: intricacies and way forward
ABSTRACTβ-catenin is an evolutionary conserved, quintessential, multifaceted protein that plays vital roles in cellular homeostasis, embryonic development, organogenesis, stem cell maintenance, cell proliferation, migration, differentiation, apoptosis, and pathogenesis of various human diseases incl...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Bioengineered |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21655979.2023.2251696 |
| _version_ | 1797729094701416448 |
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| author | Arundhathi Dev Meenakshi Vachher Chandra Prakash Prasad |
| author_facet | Arundhathi Dev Meenakshi Vachher Chandra Prakash Prasad |
| author_sort | Arundhathi Dev |
| collection | DOAJ |
| description | ABSTRACTβ-catenin is an evolutionary conserved, quintessential, multifaceted protein that plays vital roles in cellular homeostasis, embryonic development, organogenesis, stem cell maintenance, cell proliferation, migration, differentiation, apoptosis, and pathogenesis of various human diseases including cancer. β-catenin manifests both signaling and adhesive features. It acts as a pivotal player in intracellular signaling as a component of versatile WNT signaling cascade involved in embryonic development, homeostasis as well as in carcinogenesis. It is also involved in Ca2+ dependent cell adhesion via interaction with E-cadherin at the adherens junctions. Aberrant β-catenin expression and its nuclear accumulation promote the transcription of various oncogenes including c-Myc and cyclinD1, thereby contributing to tumor initiation, development, and progression. β-catenin’s expression is closely regulated at various levels including its stability, sub-cellular localization, as well as transcriptional activity. Understanding the molecular mechanisms of regulation of β-catenin and its atypical expression will provide researchers not only the novel insights into the pathogenesis and progression of cancer but also will help in deciphering new therapeutic avenues. In the present review, we have summarized the dual functions of β-catenin, its role in signaling, associated mutations as well as its role in carcinogenesis and tumor progression of various cancers. Additionally, we have discussed the challenges associated with targeting β-catenin molecule with the presently available drugs and suggested the possible way forward in designing new therapeutic alternatives against this oncogene. |
| first_indexed | 2024-03-12T11:24:03Z |
| format | Article |
| id | doaj.art-501cf89f855249b9b1f57425c6d80c80 |
| institution | Directory Open Access Journal |
| issn | 2165-5979 2165-5987 |
| language | English |
| last_indexed | 2024-03-12T11:24:03Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Bioengineered |
| spelling | doaj.art-501cf89f855249b9b1f57425c6d80c802023-09-01T12:21:35ZengTaylor & Francis GroupBioengineered2165-59792165-59872023-12-0114110.1080/21655979.2023.2251696β-catenin inhibitors in cancer therapeutics: intricacies and way forwardArundhathi Dev0Meenakshi Vachher1Chandra Prakash Prasad2Department of Medical Oncology (Laboratory), DR BRAIRCH, All India Institute of Medical Sciences, New Delhi, IndiaDepartment of Biochemistry, Institute of Home Economics, University of Delhi, New Delhi, IndiaDepartment of Medical Oncology (Laboratory), DR BRAIRCH, All India Institute of Medical Sciences, New Delhi, IndiaABSTRACTβ-catenin is an evolutionary conserved, quintessential, multifaceted protein that plays vital roles in cellular homeostasis, embryonic development, organogenesis, stem cell maintenance, cell proliferation, migration, differentiation, apoptosis, and pathogenesis of various human diseases including cancer. β-catenin manifests both signaling and adhesive features. It acts as a pivotal player in intracellular signaling as a component of versatile WNT signaling cascade involved in embryonic development, homeostasis as well as in carcinogenesis. It is also involved in Ca2+ dependent cell adhesion via interaction with E-cadherin at the adherens junctions. Aberrant β-catenin expression and its nuclear accumulation promote the transcription of various oncogenes including c-Myc and cyclinD1, thereby contributing to tumor initiation, development, and progression. β-catenin’s expression is closely regulated at various levels including its stability, sub-cellular localization, as well as transcriptional activity. Understanding the molecular mechanisms of regulation of β-catenin and its atypical expression will provide researchers not only the novel insights into the pathogenesis and progression of cancer but also will help in deciphering new therapeutic avenues. In the present review, we have summarized the dual functions of β-catenin, its role in signaling, associated mutations as well as its role in carcinogenesis and tumor progression of various cancers. Additionally, we have discussed the challenges associated with targeting β-catenin molecule with the presently available drugs and suggested the possible way forward in designing new therapeutic alternatives against this oncogene.https://www.tandfonline.com/doi/10.1080/21655979.2023.2251696β-catenincancerWNT signalingmutationsβ-catenin inhibitorsnatural compounds |
| spellingShingle | Arundhathi Dev Meenakshi Vachher Chandra Prakash Prasad β-catenin inhibitors in cancer therapeutics: intricacies and way forward Bioengineered β-catenin cancer WNT signaling mutations β-catenin inhibitors natural compounds |
| title | β-catenin inhibitors in cancer therapeutics: intricacies and way forward |
| title_full | β-catenin inhibitors in cancer therapeutics: intricacies and way forward |
| title_fullStr | β-catenin inhibitors in cancer therapeutics: intricacies and way forward |
| title_full_unstemmed | β-catenin inhibitors in cancer therapeutics: intricacies and way forward |
| title_short | β-catenin inhibitors in cancer therapeutics: intricacies and way forward |
| title_sort | β catenin inhibitors in cancer therapeutics intricacies and way forward |
| topic | β-catenin cancer WNT signaling mutations β-catenin inhibitors natural compounds |
| url | https://www.tandfonline.com/doi/10.1080/21655979.2023.2251696 |
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