Desenvolvimento de método analítico por CLAE em comprimidos de Benznidazol para a Doença de Chagas Development of an hplc analytical method for benznidazol tablets for the treatment of chagas disease
<abstract language="eng">The analytical method of high performance liquid chromatography (HPLC) for the assay of benznidazole in tablets was developed and validated following the requirements of regulatory agencies. The method used as mobile phase acetonitrile:wather 1:1, a C18 colum...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2007-10-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000500021 |
| _version_ | 1818196802286911488 |
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| author | Ana Luiza Maurer da Silva José Lamartine Soares Sobrinho Pedro José Rolim Neto Rosali Maria Ferreira da Silva Flávia Patrícia Morais de Medeiros Leduar Guedes de Lima |
| author_facet | Ana Luiza Maurer da Silva José Lamartine Soares Sobrinho Pedro José Rolim Neto Rosali Maria Ferreira da Silva Flávia Patrícia Morais de Medeiros Leduar Guedes de Lima |
| author_sort | Ana Luiza Maurer da Silva |
| collection | DOAJ |
| description | <abstract language="eng">The analytical method of high performance liquid chromatography (HPLC) for the assay of benznidazole in tablets was developed and validated following the requirements of regulatory agencies. The method used as mobile phase acetonitrile:wather 1:1, a C18 column of 12.5 cm length x 4 mm id, 5 mm particles and lambda=316 nm. The statistical analysis of the results demonstrated that the method satisfies all parameters so as to be considered a safe and efficient analytical alternative of low cost for laboratory routine. |
| first_indexed | 2024-12-12T01:39:52Z |
| format | Article |
| id | doaj.art-501e20d78a074631bbab77207f5316a6 |
| institution | Directory Open Access Journal |
| issn | 0100-4042 1678-7064 |
| language | English |
| last_indexed | 2024-12-12T01:39:52Z |
| publishDate | 2007-10-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-501e20d78a074631bbab77207f5316a62022-12-22T00:42:44ZengSociedade Brasileira de QuímicaQuímica Nova0100-40421678-70642007-10-013051163116610.1590/S0100-40422007000500021Desenvolvimento de método analítico por CLAE em comprimidos de Benznidazol para a Doença de Chagas Development of an hplc analytical method for benznidazol tablets for the treatment of chagas diseaseAna Luiza Maurer da SilvaJosé Lamartine Soares SobrinhoPedro José Rolim NetoRosali Maria Ferreira da SilvaFlávia Patrícia Morais de MedeirosLeduar Guedes de Lima<abstract language="eng">The analytical method of high performance liquid chromatography (HPLC) for the assay of benznidazole in tablets was developed and validated following the requirements of regulatory agencies. The method used as mobile phase acetonitrile:wather 1:1, a C18 column of 12.5 cm length x 4 mm id, 5 mm particles and lambda=316 nm. The statistical analysis of the results demonstrated that the method satisfies all parameters so as to be considered a safe and efficient analytical alternative of low cost for laboratory routine.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000500021development of methodvalidationhigh performance liquid chromatography |
| spellingShingle | Ana Luiza Maurer da Silva José Lamartine Soares Sobrinho Pedro José Rolim Neto Rosali Maria Ferreira da Silva Flávia Patrícia Morais de Medeiros Leduar Guedes de Lima Desenvolvimento de método analítico por CLAE em comprimidos de Benznidazol para a Doença de Chagas Development of an hplc analytical method for benznidazol tablets for the treatment of chagas disease Química Nova development of method validation high performance liquid chromatography |
| title | Desenvolvimento de método analítico por CLAE em comprimidos de Benznidazol para a Doença de Chagas Development of an hplc analytical method for benznidazol tablets for the treatment of chagas disease |
| title_full | Desenvolvimento de método analítico por CLAE em comprimidos de Benznidazol para a Doença de Chagas Development of an hplc analytical method for benznidazol tablets for the treatment of chagas disease |
| title_fullStr | Desenvolvimento de método analítico por CLAE em comprimidos de Benznidazol para a Doença de Chagas Development of an hplc analytical method for benznidazol tablets for the treatment of chagas disease |
| title_full_unstemmed | Desenvolvimento de método analítico por CLAE em comprimidos de Benznidazol para a Doença de Chagas Development of an hplc analytical method for benznidazol tablets for the treatment of chagas disease |
| title_short | Desenvolvimento de método analítico por CLAE em comprimidos de Benznidazol para a Doença de Chagas Development of an hplc analytical method for benznidazol tablets for the treatment of chagas disease |
| title_sort | desenvolvimento de metodo analitico por clae em comprimidos de benznidazol para a doenca de chagas development of an hplc analytical method for benznidazol tablets for the treatment of chagas disease |
| topic | development of method validation high performance liquid chromatography |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000500021 |
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