Inhibition of Glycolysis Reduces Disease Severity in an Autoimmune Model of Rheumatoid Arthritis

Inhibition of Glycolysis Reduces Disease Severity in an Autoimmune Model of Rheumatoid Arthritis

The K/BxN mouse is a spontaneous model of arthritis driven by T cell receptor transgenic CD4+ T cells from the KRN strain that are activated by glucose-6-phosphate isomerase (GPI) peptides presented by the H-2g7 allele from the NOD strain. It is a model of autoimmune seropositive arthritis because t...

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Bibliographic Details
Main Authors: Georges Abboud, Seung-Chul Choi, Nathalie Kanda, Leilani Zeumer-Spataro, Derry C. Roopenian, Laurence Morel
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
arthritis
mouse
follicular helper T cells
glycolysis
metabolism
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01973/full

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