R1 Vascular or Parenchymal Margins: What Is the Impact after Resection of Intrahepatic Cholangiocarcinoma?
<b>Background</b>: to date, long-term outcomes of R1 vascular (R1vasc) and R1 parenchymal (R1par) resections in the setting of intrahepatic cholangiocarcinoma (iCCA) have been examined in only one study which did not find significant difference. <b>Patients and Methods</b>: w...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/20/5151 |
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| author | Andrea Mabilia Alessandro D. Mazzotta Fabien Robin Mohammed Ghallab Eric Vibert René Adam Daniel Cherqui Antonio Sa Cunha Daniel Azoulay Chady Salloum Gabriella Pittau Oriana Ciacio Marc Antoine Allard Karim Boudjema Laurent Sulpice Nicolas Golse |
| author_facet | Andrea Mabilia Alessandro D. Mazzotta Fabien Robin Mohammed Ghallab Eric Vibert René Adam Daniel Cherqui Antonio Sa Cunha Daniel Azoulay Chady Salloum Gabriella Pittau Oriana Ciacio Marc Antoine Allard Karim Boudjema Laurent Sulpice Nicolas Golse |
| author_sort | Andrea Mabilia |
| collection | DOAJ |
| description | <b>Background</b>: to date, long-term outcomes of R1 vascular (R1vasc) and R1 parenchymal (R1par) resections in the setting of intrahepatic cholangiocarcinoma (iCCA) have been examined in only one study which did not find significant difference. <b>Patients and Methods</b>: we analyzed consecutive patients who underwent iCCA resection between 2000 and 2019 in two tertiary French medical centers. We report overall survival (OS) and disease-free-survival (DFS). Univariate and multivariate analyses were performed to determine associated factors. <b>Results</b>: 195 patients were analyzed. The number of R0, R1par and R1vasc patients was 128 (65.7%), 57 (29.2%) and 10 (5.1%), respectively. The 1- and 2-year OS rates in the R0, R1par and R1vasc groups were 83%, 87%, 57% and 69%, 75%, 45%, respectively (<i>p</i> = 0.30). The 1- and 2-year DFS rates in the R0, R1par and R1vasc groups were 58%, 50%, 30% and 43%, 28%, 10%, respectively (<i>p</i> = 0.019). Resection classification (HR 1.56; <i>p</i> = 0.003) was one of the independent predictors of DFS in multivariate analysis. <b>Conclusions</b>: the survival outcomes after R1par resection are intermediate to those after R0 or R1vasc resection. R1vasc resection should be avoided in patients with iCCA as it does not provide satisfactory oncological outcomes. |
| first_indexed | 2024-03-09T20:31:00Z |
| format | Article |
| id | doaj.art-501e9c2de86c4b1fb7228c30783ae166 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T20:31:00Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-501e9c2de86c4b1fb7228c30783ae1662023-11-23T23:22:47ZengMDPI AGCancers2072-66942022-10-011420515110.3390/cancers14205151R1 Vascular or Parenchymal Margins: What Is the Impact after Resection of Intrahepatic Cholangiocarcinoma?Andrea Mabilia0Alessandro D. Mazzotta1Fabien Robin2Mohammed Ghallab3Eric Vibert4René Adam5Daniel Cherqui6Antonio Sa Cunha7Daniel Azoulay8Chady Salloum9Gabriella Pittau10Oriana Ciacio11Marc Antoine Allard12Karim Boudjema13Laurent Sulpice14Nicolas Golse15Department of Surgery, Paul-Brousse Hospital, Assistance Publique Hôpitaux de Paris, Centre Hepato-Biliaire, 94800 Villejuif, FranceDepartment of Digestive, Oncological and Metabolic Surgery, Institute Mutualiste Montsouris, 75014 Paris, FranceDepartment of Hepatobiliary and Digestive Surgery, CHU Rennes, 35000 Rennes, FranceThe Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham B15 2TH, UKDepartment of Surgery, Paul-Brousse Hospital, Assistance Publique Hôpitaux de Paris, Centre Hepato-Biliaire, 94800 Villejuif, FranceDepartment of Surgery, Paul-Brousse Hospital, Assistance Publique Hôpitaux de Paris, Centre Hepato-Biliaire, 94800 Villejuif, FranceDepartment of Surgery, Paul-Brousse Hospital, Assistance Publique Hôpitaux de Paris, Centre Hepato-Biliaire, 94800 Villejuif, FranceDepartment of Surgery, Paul-Brousse Hospital, Assistance Publique Hôpitaux de Paris, Centre Hepato-Biliaire, 94800 Villejuif, FranceDepartment of Surgery, Paul-Brousse Hospital, Assistance Publique Hôpitaux de Paris, Centre Hepato-Biliaire, 94800 Villejuif, FranceDepartment of Surgery, Paul-Brousse Hospital, Assistance Publique Hôpitaux de Paris, Centre Hepato-Biliaire, 94800 Villejuif, FranceDepartment of Surgery, Paul-Brousse Hospital, Assistance Publique Hôpitaux de Paris, Centre Hepato-Biliaire, 94800 Villejuif, FranceDepartment of Surgery, Paul-Brousse Hospital, Assistance Publique Hôpitaux de Paris, Centre Hepato-Biliaire, 94800 Villejuif, FranceDepartment of Surgery, Paul-Brousse Hospital, Assistance Publique Hôpitaux de Paris, Centre Hepato-Biliaire, 94800 Villejuif, FranceDepartment of Hepatobiliary and Digestive Surgery, CHU Rennes, 35000 Rennes, FranceDepartment of Hepatobiliary and Digestive Surgery, CHU Rennes, 35000 Rennes, FranceDepartment of Surgery, Paul-Brousse Hospital, Assistance Publique Hôpitaux de Paris, Centre Hepato-Biliaire, 94800 Villejuif, France<b>Background</b>: to date, long-term outcomes of R1 vascular (R1vasc) and R1 parenchymal (R1par) resections in the setting of intrahepatic cholangiocarcinoma (iCCA) have been examined in only one study which did not find significant difference. <b>Patients and Methods</b>: we analyzed consecutive patients who underwent iCCA resection between 2000 and 2019 in two tertiary French medical centers. We report overall survival (OS) and disease-free-survival (DFS). Univariate and multivariate analyses were performed to determine associated factors. <b>Results</b>: 195 patients were analyzed. The number of R0, R1par and R1vasc patients was 128 (65.7%), 57 (29.2%) and 10 (5.1%), respectively. The 1- and 2-year OS rates in the R0, R1par and R1vasc groups were 83%, 87%, 57% and 69%, 75%, 45%, respectively (<i>p</i> = 0.30). The 1- and 2-year DFS rates in the R0, R1par and R1vasc groups were 58%, 50%, 30% and 43%, 28%, 10%, respectively (<i>p</i> = 0.019). Resection classification (HR 1.56; <i>p</i> = 0.003) was one of the independent predictors of DFS in multivariate analysis. <b>Conclusions</b>: the survival outcomes after R1par resection are intermediate to those after R0 or R1vasc resection. R1vasc resection should be avoided in patients with iCCA as it does not provide satisfactory oncological outcomes.https://www.mdpi.com/2072-6694/14/20/5151intrahepatic cholangiocarcinomaR1 resectionhepatectomyprognosishistopathology |
| spellingShingle | Andrea Mabilia Alessandro D. Mazzotta Fabien Robin Mohammed Ghallab Eric Vibert René Adam Daniel Cherqui Antonio Sa Cunha Daniel Azoulay Chady Salloum Gabriella Pittau Oriana Ciacio Marc Antoine Allard Karim Boudjema Laurent Sulpice Nicolas Golse R1 Vascular or Parenchymal Margins: What Is the Impact after Resection of Intrahepatic Cholangiocarcinoma? Cancers intrahepatic cholangiocarcinoma R1 resection hepatectomy prognosis histopathology |
| title | R1 Vascular or Parenchymal Margins: What Is the Impact after Resection of Intrahepatic Cholangiocarcinoma? |
| title_full | R1 Vascular or Parenchymal Margins: What Is the Impact after Resection of Intrahepatic Cholangiocarcinoma? |
| title_fullStr | R1 Vascular or Parenchymal Margins: What Is the Impact after Resection of Intrahepatic Cholangiocarcinoma? |
| title_full_unstemmed | R1 Vascular or Parenchymal Margins: What Is the Impact after Resection of Intrahepatic Cholangiocarcinoma? |
| title_short | R1 Vascular or Parenchymal Margins: What Is the Impact after Resection of Intrahepatic Cholangiocarcinoma? |
| title_sort | r1 vascular or parenchymal margins what is the impact after resection of intrahepatic cholangiocarcinoma |
| topic | intrahepatic cholangiocarcinoma R1 resection hepatectomy prognosis histopathology |
| url | https://www.mdpi.com/2072-6694/14/20/5151 |
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