JAK2-V617F Mutation Combined with Philadelphia Chromosome-Positive Chronic Myeloid Leukaemia: a Case Report
Myeloproliferative neoplasms (MPNs) such as polycythemia vera, essential thrombocythemia, primary myelofibrosis and chronic myeloid leukemia have too similar and accurate way to differentiate their is study of genetic disorders in these patients. Philadelphia chromosome is a sure way to definitively...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2011-04-01
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| Series: | International Journal of Hematology-Oncology and Stem Cell Research |
| Subjects: | |
| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/19571.pdf&manuscript_id=19571 |
| _version_ | 1797766781717184512 |
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| author | Farhad Shaveisi Zadeh Saber Ghanbari Haji Shure Mohammad Erfan Zare Mehrdad Payande |
| author_facet | Farhad Shaveisi Zadeh Saber Ghanbari Haji Shure Mohammad Erfan Zare Mehrdad Payande |
| author_sort | Farhad Shaveisi Zadeh |
| collection | DOAJ |
| description | Myeloproliferative neoplasms (MPNs) such as polycythemia vera, essential thrombocythemia, primary myelofibrosis and chronic myeloid leukemia have too similar and accurate way to differentiate their is study of genetic disorders in these patients. Philadelphia chromosome is a sure way to definitively diagnose CML. Recently, JAK2V617F mutation introduced as a diagnostic marker for other Myeloproliferative neoplasms. Many studies show that the absence of the JAK2 mutation in chronic phase Philadelphia positive CML. In contrast with these reports, more recently, several cases with the coexistence of Philadelphia positive chromosome and JAK2V617F mutation in blood and bone marrow samples were reported. Here, we report a patient that have the Philadelphia chromosome disorder and JAK2V617F mutation in same time. |
| first_indexed | 2024-03-12T20:29:12Z |
| format | Article |
| id | doaj.art-501f3cd3383049f09223be70dea9419d |
| institution | Directory Open Access Journal |
| issn | 2008-3009 2008-2207 |
| language | English |
| last_indexed | 2024-03-12T20:29:12Z |
| publishDate | 2011-04-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | International Journal of Hematology-Oncology and Stem Cell Research |
| spelling | doaj.art-501f3cd3383049f09223be70dea9419d2023-08-02T00:12:02ZengTehran University of Medical SciencesInternational Journal of Hematology-Oncology and Stem Cell Research2008-30092008-22072011-04-01523437JAK2-V617F Mutation Combined with Philadelphia Chromosome-Positive Chronic Myeloid Leukaemia: a Case ReportFarhad Shaveisi ZadehSaber Ghanbari Haji ShureMohammad Erfan ZareMehrdad PayandeMyeloproliferative neoplasms (MPNs) such as polycythemia vera, essential thrombocythemia, primary myelofibrosis and chronic myeloid leukemia have too similar and accurate way to differentiate their is study of genetic disorders in these patients. Philadelphia chromosome is a sure way to definitively diagnose CML. Recently, JAK2V617F mutation introduced as a diagnostic marker for other Myeloproliferative neoplasms. Many studies show that the absence of the JAK2 mutation in chronic phase Philadelphia positive CML. In contrast with these reports, more recently, several cases with the coexistence of Philadelphia positive chromosome and JAK2V617F mutation in blood and bone marrow samples were reported. Here, we report a patient that have the Philadelphia chromosome disorder and JAK2V617F mutation in same time.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/19571.pdf&manuscript_id=19571Myeloproliferative NeoplasmsChronic Myeloid LeukemiaJAK2V617FJAK2 |
| spellingShingle | Farhad Shaveisi Zadeh Saber Ghanbari Haji Shure Mohammad Erfan Zare Mehrdad Payande JAK2-V617F Mutation Combined with Philadelphia Chromosome-Positive Chronic Myeloid Leukaemia: a Case Report International Journal of Hematology-Oncology and Stem Cell Research Myeloproliferative Neoplasms Chronic Myeloid Leukemia JAK2V617F JAK2 |
| title | JAK2-V617F Mutation Combined with Philadelphia Chromosome-Positive Chronic Myeloid Leukaemia: a Case Report |
| title_full | JAK2-V617F Mutation Combined with Philadelphia Chromosome-Positive Chronic Myeloid Leukaemia: a Case Report |
| title_fullStr | JAK2-V617F Mutation Combined with Philadelphia Chromosome-Positive Chronic Myeloid Leukaemia: a Case Report |
| title_full_unstemmed | JAK2-V617F Mutation Combined with Philadelphia Chromosome-Positive Chronic Myeloid Leukaemia: a Case Report |
| title_short | JAK2-V617F Mutation Combined with Philadelphia Chromosome-Positive Chronic Myeloid Leukaemia: a Case Report |
| title_sort | jak2 v617f mutation combined with philadelphia chromosome positive chronic myeloid leukaemia a case report |
| topic | Myeloproliferative Neoplasms Chronic Myeloid Leukemia JAK2V617F JAK2 |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/19571.pdf&manuscript_id=19571 |
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