Effects of antidepressants on serum concentrations of bone metabolism markers and major electrolytes in patients from routine psychiatric practice
Background/Aim. Data about effects of antidepressant on calcium, phosphorous and magnesium metabolisms are very scorce. The aim of this study was to investigate effects of antidepressants on serum concentration of bone metabolism markers and main electrolytes in patients from routine psychiatric pra...
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2017-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2017/0042-84501600084R.pdf |
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| author | Riznić Nikola Milovanović Dragan R. Đukić-Dejanović Slavica Janković Slobodan M. Ravanić Dragan Ignjatović-Ristić Dragana Petrović Dušan Jovanović Mirjana Mladenović Violeta Ružić-Zečević Dejana Janjić Vladimir |
| author_facet | Riznić Nikola Milovanović Dragan R. Đukić-Dejanović Slavica Janković Slobodan M. Ravanić Dragan Ignjatović-Ristić Dragana Petrović Dušan Jovanović Mirjana Mladenović Violeta Ružić-Zečević Dejana Janjić Vladimir |
| author_sort | Riznić Nikola |
| collection | DOAJ |
| description | Background/Aim. Data about effects of antidepressant on calcium, phosphorous and magnesium metabolisms are very scorce. The aim of this study was to investigate effects of antidepressants on serum concentration of bone metabolism markers and main electrolytes in patients from routine psychiatric practice. Methods. A prospective, before-and-after, time-series research included 9 males and 24 females, with average 53.3 ± 11.5 years-of-age, suffering from depression (n = 26) and neurotic disorders (n = 7), mostly taking selective serotonin reuptake inhibitors. We measured analytes at baseline, and 4th, 6th and 12th weeks during the treatment and tested the parameter changes from baseline and the trends with appropriate statistics at p ≤ 0.05 significance level. Results. The age above 60 years was a significant factor for appearance of negative cumulative changes (in percent) of 25-hydroxyvitamin D – 25(OH)D concentrations from the base-line (OR = 11.4, 95% CI 1.2–113.1, p = 0.037). Serum concentrations of calcium significantly correlated with sodium (rs = 0.531, p < 0.001), with chloride (r = 0.496, p < 0.001), with magnesium (rs = 0.402, p < 0.001) and with osteocalcin (r = 0.240, p = 0.019). Significant correlations were among phosphorous with chloride (r = -0.218, p = 0.035); magnesium with sodium (r = 0.295, p = 0.004) and with potassium, (r = 0.273, p = 0.009); osteocalcin with C-telopeptide (r = 0.760, p < 0.001) with sodium (r = 0.215, p = 0.039) and with chloride (r = 0.209, p = 0.041); sodium with chloride (r = 0.722, p < 0.001). There were no statistically significant changes between antidepressant treatment and changes of absolute serum concentration of calcium, magnesium, phosphorous, 25(OH)D, osteocalcin, C-telopeptide, sodium, potassium and chloride. There were no statistically significant changes in frequency of disturbances in values of laboratory analytes (below/above lower/upper normal limits), too. Conclusion. Antidepressant treatment was not significantly associated with the changes in study analytes but some of them positively correlated with each other, suggesting the need for individual patient approach and further research in the field of bone metabolism in patients with mental disorders. |
| first_indexed | 2024-04-12T16:54:30Z |
| format | Article |
| id | doaj.art-5020024070734911b2cb5df7358907d8 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 2406-0720 |
| language | English |
| last_indexed | 2024-04-12T16:54:30Z |
| publishDate | 2017-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-5020024070734911b2cb5df7358907d82022-12-22T03:24:16ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502406-07202017-01-0174761562410.2298/VSP150828084R0042-84501600084REffects of antidepressants on serum concentrations of bone metabolism markers and major electrolytes in patients from routine psychiatric practiceRiznić Nikola0Milovanović Dragan R.1Đukić-Dejanović Slavica2Janković Slobodan M.3Ravanić Dragan4Ignjatović-Ristić Dragana5Petrović Dušan6Jovanović Mirjana7Mladenović Violeta8Ružić-Zečević Dejana9Janjić Vladimir10nemanemanemanemanemanemanemanemanemanemanemaBackground/Aim. Data about effects of antidepressant on calcium, phosphorous and magnesium metabolisms are very scorce. The aim of this study was to investigate effects of antidepressants on serum concentration of bone metabolism markers and main electrolytes in patients from routine psychiatric practice. Methods. A prospective, before-and-after, time-series research included 9 males and 24 females, with average 53.3 ± 11.5 years-of-age, suffering from depression (n = 26) and neurotic disorders (n = 7), mostly taking selective serotonin reuptake inhibitors. We measured analytes at baseline, and 4th, 6th and 12th weeks during the treatment and tested the parameter changes from baseline and the trends with appropriate statistics at p ≤ 0.05 significance level. Results. The age above 60 years was a significant factor for appearance of negative cumulative changes (in percent) of 25-hydroxyvitamin D – 25(OH)D concentrations from the base-line (OR = 11.4, 95% CI 1.2–113.1, p = 0.037). Serum concentrations of calcium significantly correlated with sodium (rs = 0.531, p < 0.001), with chloride (r = 0.496, p < 0.001), with magnesium (rs = 0.402, p < 0.001) and with osteocalcin (r = 0.240, p = 0.019). Significant correlations were among phosphorous with chloride (r = -0.218, p = 0.035); magnesium with sodium (r = 0.295, p = 0.004) and with potassium, (r = 0.273, p = 0.009); osteocalcin with C-telopeptide (r = 0.760, p < 0.001) with sodium (r = 0.215, p = 0.039) and with chloride (r = 0.209, p = 0.041); sodium with chloride (r = 0.722, p < 0.001). There were no statistically significant changes between antidepressant treatment and changes of absolute serum concentration of calcium, magnesium, phosphorous, 25(OH)D, osteocalcin, C-telopeptide, sodium, potassium and chloride. There were no statistically significant changes in frequency of disturbances in values of laboratory analytes (below/above lower/upper normal limits), too. Conclusion. Antidepressant treatment was not significantly associated with the changes in study analytes but some of them positively correlated with each other, suggesting the need for individual patient approach and further research in the field of bone metabolism in patients with mental disorders.http://www.doiserbia.nb.rs/img/doi/0042-8450/2017/0042-84501600084R.pdfantidepressive agentsbone and bonesmetabolismelectrolytesrisk assessmentclinical chemistry tests |
| spellingShingle | Riznić Nikola Milovanović Dragan R. Đukić-Dejanović Slavica Janković Slobodan M. Ravanić Dragan Ignjatović-Ristić Dragana Petrović Dušan Jovanović Mirjana Mladenović Violeta Ružić-Zečević Dejana Janjić Vladimir Effects of antidepressants on serum concentrations of bone metabolism markers and major electrolytes in patients from routine psychiatric practice Vojnosanitetski Pregled antidepressive agents bone and bones metabolism electrolytes risk assessment clinical chemistry tests |
| title | Effects of antidepressants on serum concentrations of bone metabolism markers and major electrolytes in patients from routine psychiatric practice |
| title_full | Effects of antidepressants on serum concentrations of bone metabolism markers and major electrolytes in patients from routine psychiatric practice |
| title_fullStr | Effects of antidepressants on serum concentrations of bone metabolism markers and major electrolytes in patients from routine psychiatric practice |
| title_full_unstemmed | Effects of antidepressants on serum concentrations of bone metabolism markers and major electrolytes in patients from routine psychiatric practice |
| title_short | Effects of antidepressants on serum concentrations of bone metabolism markers and major electrolytes in patients from routine psychiatric practice |
| title_sort | effects of antidepressants on serum concentrations of bone metabolism markers and major electrolytes in patients from routine psychiatric practice |
| topic | antidepressive agents bone and bones metabolism electrolytes risk assessment clinical chemistry tests |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2017/0042-84501600084R.pdf |
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