Kir1.1 and SUR1 are not implicated as subunits of an adenosine triphosphate-sensitive potassium channel involved in diazoxide cardioprotectionCentral MessagePerspective

Kir1.1 and SUR1 are not implicated as subunits of an adenosine triphosphate-sensitive potassium channel involved in diazoxide cardioprotectionCentral MessagePerspective

Objective: The adenosine triphosphate-sensitive potassium channel opener diazoxide mimics ischemic preconditioning and is cardioprotective. Clarification of diazoxide's site and mechanism of action could lead to targeted pharmacologic therapies for patients undergoing cardiac surgery. Several m...

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Bibliographic Details
Main Authors: Jie Wang, MD, Kyriakos Papanicolaou, PhD, Robert Tryon, PhD, Janelle Sangalang, BA, Ben Salazar, BS, Alejandro Suarez-Pierre, MD, Jie Dong, MD, Anson Lee, BS, BA, Emily Larson, BS, Sari Holmes, PhD, Brian O’Rourke, PhD, Colin Nichols, PhD, Jennifer Lawton, MD
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:JTCVS Open
Subjects:
basic science
ion channels
ischemia
preconditioning
Online Access:http://www.sciencedirect.com/science/article/pii/S2666273623001596

Internet

http://www.sciencedirect.com/science/article/pii/S2666273623001596

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