Dopamine lesions alter the striatal encoding of single-limb gait
The striatum serves an important role in motor control, and neurons in this area encode the body’s initiation, cessation, and speed of locomotion. However, it remains unclear whether the same neurons also encode the step-by-step rhythmic motor patterns of individual limbs that characterize gait. By...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2024-03-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/92821 |
| _version_ | 1797245263912370176 |
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| author | Long Yang Deepak Singla Alexander K Wu Katy A Cross Sotiris C Masmanidis |
| author_facet | Long Yang Deepak Singla Alexander K Wu Katy A Cross Sotiris C Masmanidis |
| author_sort | Long Yang |
| collection | DOAJ |
| description | The striatum serves an important role in motor control, and neurons in this area encode the body’s initiation, cessation, and speed of locomotion. However, it remains unclear whether the same neurons also encode the step-by-step rhythmic motor patterns of individual limbs that characterize gait. By combining high-speed video tracking, electrophysiology, and optogenetic tagging, we found that a sizable population of both D1 and D2 receptor expressing medium spiny projection neurons (MSNs) were phase-locked to the gait cycle of individual limbs in mice. Healthy animals showed balanced limb phase-locking between D1 and D2 MSNs, while dopamine depletion led to stronger phase-locking in D2 MSNs. These findings indicate that striatal neurons represent gait on a single-limb and step basis, and suggest that elevated limb phase-locking of D2 MSNs may underlie some of the gait impairments associated with dopamine loss. |
| first_indexed | 2024-04-24T19:24:08Z |
| format | Article |
| id | doaj.art-5022af0683fb4f81a886f8d71278c767 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-24T19:24:08Z |
| publishDate | 2024-03-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-5022af0683fb4f81a886f8d71278c7672024-03-25T15:57:28ZengeLife Sciences Publications LtdeLife2050-084X2024-03-011210.7554/eLife.92821Dopamine lesions alter the striatal encoding of single-limb gaitLong Yang0https://orcid.org/0000-0001-8317-8768Deepak Singla1https://orcid.org/0000-0001-7699-7079Alexander K Wu2Katy A Cross3Sotiris C Masmanidis4https://orcid.org/0000-0002-8699-3335Department of Neurobiology, University of California Los Angeles, Los Angeles, United StatesDepartment of Bioengineering, University of California Los Angeles, Los Angeles, United StatesDepartment of Neurobiology, University of California Los Angeles, Los Angeles, United StatesDepartment of Neurology, University of California Los Angeles, Los Angeles, United StatesDepartment of Neurobiology, University of California Los Angeles, Los Angeles, United States; California Nanosystems Institute, University of California Los Angeles, Los Angeles, United StatesThe striatum serves an important role in motor control, and neurons in this area encode the body’s initiation, cessation, and speed of locomotion. However, it remains unclear whether the same neurons also encode the step-by-step rhythmic motor patterns of individual limbs that characterize gait. By combining high-speed video tracking, electrophysiology, and optogenetic tagging, we found that a sizable population of both D1 and D2 receptor expressing medium spiny projection neurons (MSNs) were phase-locked to the gait cycle of individual limbs in mice. Healthy animals showed balanced limb phase-locking between D1 and D2 MSNs, while dopamine depletion led to stronger phase-locking in D2 MSNs. These findings indicate that striatal neurons represent gait on a single-limb and step basis, and suggest that elevated limb phase-locking of D2 MSNs may underlie some of the gait impairments associated with dopamine loss.https://elifesciences.org/articles/92821basal gangliasingle unit recordingssteppingwalkingparkinson's diseasedirect indirect pathway |
| spellingShingle | Long Yang Deepak Singla Alexander K Wu Katy A Cross Sotiris C Masmanidis Dopamine lesions alter the striatal encoding of single-limb gait eLife basal ganglia single unit recordings stepping walking parkinson's disease direct indirect pathway |
| title | Dopamine lesions alter the striatal encoding of single-limb gait |
| title_full | Dopamine lesions alter the striatal encoding of single-limb gait |
| title_fullStr | Dopamine lesions alter the striatal encoding of single-limb gait |
| title_full_unstemmed | Dopamine lesions alter the striatal encoding of single-limb gait |
| title_short | Dopamine lesions alter the striatal encoding of single-limb gait |
| title_sort | dopamine lesions alter the striatal encoding of single limb gait |
| topic | basal ganglia single unit recordings stepping walking parkinson's disease direct indirect pathway |
| url | https://elifesciences.org/articles/92821 |
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