Design, Synthesis, Biological Evaluation and Molecular Docking of Novel F-18-Labeled Focal Adhesion Kinase Inhibitors as Potential Tumor Radiotracers

Design, Synthesis, Biological Evaluation and Molecular Docking of Novel F-18-Labeled Focal Adhesion Kinase Inhibitors as Potential Tumor Radiotracers

Tumor diagnosis, especially at the early stages, holds immense significance. Focal adhesion kinase (FAK) is often highly expressed across various types of tumors, making it a promising target for both therapy and diagnosis. In this study, seven novel inhibitors were designed and synthesized. The inh...

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Bibliographic Details
Main Authors: Hailong Yang, Ye Li, Huaju Liang, Chun Cui, Lu Gan, Huabei Zhang
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Molecules
Subjects:
FAK
inhibitor
radiotracer
F-18 label
molecular docking
Online Access:https://www.mdpi.com/1420-3049/29/6/1224

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